Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 1,228

The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.

Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children

Open access
Weiss, Scott L., Peters, Mark J., Alhazzani, Waleed, Agus, Michael S. D., Flori, Heidi R., Inwald, David P., Nadel, Simon, Schlapbach, Luregn J., Tasker, Robert C., Argent, Andrew C., Brierley, Joe, Carcillo, Joseph, Carrol, Enitan D., Carroll, Christopher L., Cheifetz, Ira M., Choong, Karen, Cies, Jeffry J., Cruz, Andrea T., De Luca, Daniele, Deep, Akash, Faust, Saul N., De Oliveira, Claudio Flauzino, Hall, Mark W., Ishimine, Paul, Javouhey, Etienne, Joosten, Koen F. M., Joshi, Poonam, Karam, Oliver, Kneyber, Martin C. J., Lemson, Joris, MacLaren, Graeme, Mehta, Nilesh M., Møller, Morten Hylander, Newth, Christopher J. L., Nguyen, Trung C., Nishisaki, Akira, Nunnally, Mark E., Parker, Margaret M., Paul, Raina M., Randolph, Adrienne G., Ranjit, Suchitra, Romer, Lewis H., Scott, Halden F., Tume, Lyvonne N., Verger, Judy T., Williams, Eric A., Wolf, Joshua, Wong, Hector R., Zimmerman, Jerry J., Kissoon, Niranjan, Tissieres, Pierre·2020·Pediatric Critical Care Medicine
DOI 10.1097/pcc.0000000000002198
Open this paper in CoChat — free account

Abstract

Objectives: To develop evidence-based recommendations for clinicians caring for children (including infants, school-aged children, and adolescents) with septic shock and other sepsis-associated organ dysfunction. Design: A panel of 49 international experts, representing 12 international organizations, as well as three methodologists and three public members was convened. Panel members assembled at key international meetings (for those panel members attending the conference), and a stand-alone meeting was held for all panel members in November 2018. A formal conflict-of-interest policy was developed at the onset of the process and enforced throughout. Teleconferences and electronic-based discussion among the chairs, co-chairs, methodologists, and group heads, as well as within subgroups, served as an integral part of the guideline development process. Methods: The panel consisted of six subgroups: recognition and management of infection, hemodynamics and resuscitation, ventilation, endocrine and metabolic therapies, adjunctive therapies, and research priorities. We conducted a systematic review for each Population, Intervention, Control, and Outcomes question to identify the best available evidence, statistically summarized the evidence, and then assessed the quality of evidence using the Grading of Recommendations Assessment, Development, and Evaluation approach. We used the evidence-to-decision framework to formulate recommendations as strong or weak, or as a best practice statement. In addition, “in our practice” statements were included when evidence was inconclusive to issue a recommendation, but the panel felt that some guidance based on practice patterns may be appropriate. Results: The panel provided 77 statements on the management and resuscitation of children with septic shock and other sepsis-associated organ dysfunction. Overall, six were strong recommendations, 52 were weak recommendations, and nine were best-practice statements. For 13 questions, no recommendations could be made; but, for 10 of these, “in our practice” statements were provided. In addition, 49 research priorities were identified. Conclusions: A large cohort of international experts was able to achieve consensus regarding many recommendations for the best care of children with sepsis, acknowledging that most aspects of care had relatively low quality of evidence resulting in the frequent issuance of weak recommendations. Despite this challenge, these recommendations regarding the management of children with septic shock and other sepsis-associated organ dysfunction provide a foundation for consistent care to improve outcomes and inform future research.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1097/pcc.0000000000002198

Cites

53 of 53 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 53 references

Cited by

See all 1,228

Metadata

Authors
Weiss, S. L., Peters, M. J., Alhazzani, W., Agus, M. S. D., Flori, H. R., Inwald, D. P., Nadel, S., Schlapbach, L. J., Tasker, R. C., Argent, A. C., Brierley, J., Carcillo, J., Carrol, E. D., Carroll, C. L., Cheifetz, I. M., Choong, K., Cies, J. J., Cruz, A. T., De Luca, D., Deep, A., Faust, S. N., De Oliveira, C. F., Hall, M. W., Ishimine, P., Javouhey, E., Joosten, K. F. M., Joshi, P., Karam, O., Kneyber, M. C. J., Lemson, J., MacLaren, G., Mehta, N. M., Møller, M. H., Newth, C. J. L., Nguyen, T. C., Nishisaki, A., Nunnally, M. E., Parker, M. M., Paul, R. M., Randolph, A. G., Ranjit, S., Romer, L. H., Scott, H. F., Tume, L. N., Verger, J. T., Williams, E. A., Wolf, J., Wong, H. R., Zimmerman, J. J., Kissoon, N., & Tissieres, P.
Venue
Pediatric Critical Care Medicine
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2020-02
Volume
21
Issue
2
Pages
e52-e106
ISSN
1529-7535 (ISSN-L)
DOI
10.1097/pcc.0000000000002198
OpenAlex
W3004427938
Cited by
1,228
References
53
FWCI
119.19
Type
journal article
Language
en
Open access
green

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children. https://app.cochat.ai/papers/10.1097/pcc.0000000000002198
The paper
Weiss, S. L., Peters, M. J., Alhazzani, W., Agus, M. S. D., Flori, H. R., Inwald, D. P., Nadel, S., Schlapbach, L. J., Tasker, R. C., Argent, A. C., Brierley, J., Carcillo, J., Carrol, E. D., Carroll, C. L., Cheifetz, I. M., Choong, K., Cies, J. J., Cruz, A. T., De Luca, D., . . . Tissieres, P. (2020). Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children. Pediatric Critical Care Medicine. https://doi.org/10.1097/pcc.0000000000002198

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.