The DOI matches its Crossref record.
Risk factors for central line-associated bloodstream infection in a pediatric cardiac intensive care unit
Abstract
Objective To identify risk factors for central line-associated bloodstream infection (BSI) in patients receiving care in a pediatric cardiac intensive care unit. Design Matched case-control study. Setting CICU at Children's Hospital Boston. Patients Central line-associated BSI cases were identified between April 2004 and December 2006. We identified two randomly selected control patients who had a central vascular catheter and were admitted within 7 days of each index case. Measurements and main results Univariate and multivariate conditional logistic regression analyses were used to identify risk factors for central line-associated BSI. In a secondary analysis, risk factors for central line-associated BSI in those cases who underwent cardiac surgery were sought. During the study period, 67 central line-associated BSIs occurred in 61 patients. Independent risk factors for central line-associated BSI were nonelective admission for medical management (odds ratio [OR] = 6.51 [1.58-26.78]), the presence of noncardiac comorbidities (OR = 4.95 [1.49-16.49]), initial absolute neutrophil count or =3 units (OR = 5.56 [1.35-22.87]), central line days > or =7 (OR = 6.06 [1.65-21.83]), and use of hydrocortisone (OR = 28.94 [2.55-330.37]). In those patients who underwent cardiac surgery (n = 37 cases and 108 controls), independent risk factors for central line-associated BSI were admission weight or =15 (OR = 3.44 [1.19-9.92]), blood product exposure > or =3 units (OR = 3.38 [1.28-11.76])…
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“In addition, the administration of high dose glucocorticoids may be associated with increased morbidity [23-25].”
From Management of the Low Cardiac Output Syndrome Following Surgery for Congenital Heart Disease (2016) · cites this paper as [23]
In the citing paper
“Post-operative hydrocortisone administration has been identified as an independent risk factor for the development of a catheter-associated bloodstream infection in infants after heart surgery [23].”
From Management of the Low Cardiac Output Syndrome Following Surgery for Congenital Heart Disease (2016) · cites this paper as [23]
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Cited by
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Management of the Low Cardiac Output Syndrome Following Surgery for Congenital Heart Disease
K. Chandler, H., & Kirsch, R. (2016) · Current Cardiology Reviews · doi:10.2174/1573403x12666151119164647 · Cited by 74
“In addition, the administration of high dose glucocorticoids may be associated with increased morbidity [23-25].”
Background
Metadata
- Authors
- Costello, J. M., Graham, D. A., Morrow, D. F., Potter-Bynoe, G., Sandora, T. J., & Laussen, P. C.
- Affiliations
- Boston Children's Hospital (US)
- Venue
- Pediatric Critical Care Medicine
- Published
- 2009-07
- Volume
- 10
- Issue
- 4
- Pages
- 453-459
- ISSN
- 1529-7535 (ISSN-L)
- OpenAlex
- W1996570654
- Cited by
- 112
- References
- 0
- Citations by year
- 2026: 1 · 2024: 6 · 2023: 7 · 2022: 5 · 2021: 8 · 2020: 8 · 2019: 5 · 2018: 6 · 2017: 10 · 2016: 7 · 2015: 4 · 2014: 8 · 2013: 10 · 2012: 12
- FWCI
- 12.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pediatric Critical Care Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Central Venous Catheters and Hemodialysis
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Nosocomial Infections in ICU
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Infective Endocarditis Diagnosis and Management
- Keywords
- central line-associated bloodstream infection, pediatric cardiac intensive care, risk factors, central venous catheters, cardiac surgery, cortisol, blood product exposure, mechanical ventilation, neutropenia, device-related infection, pediatric congenital heart disease, nosocomial infection prevention, catheter dwell time
- MeSH terms
- Catheterization, Central Venous, Cross Infection, Female, Heart Defects, Congenital, Heart Diseases, Cardiac Surgical Procedures, Humans, Infant, Infant, Newborn, Male, Risk Factors, Time Factors, Intensive Care Units, Pediatric, Comorbidity, Case-Control Studies, Bacteremia, Catheter-Related Infections
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