The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Interpretation of P53 Immunohistochemistry in Endometrial Carcinomas: Toward Increased Reproducibility
Open accessAbstract
P53 immunohistochemistry has evolved into an accurate surrogate reflecting the underlying TP53 mutation status of a tumor, and has utility in the diagnostic workup of endometrial carcinomas. Recent work predominantly carried out in tubo-ovarian high-grade serous carcinoma has revealed 4 main patterns of p53 staining (normal/wild-type, complete absence, overexpression, and cytoplasmic); the latter 3 patterns are variably termed abnormal/aberrant/mutation-type and are strongly predictive of an underlying TP53 mutation. The aim of this review is to provide practical advice to pathologists regarding various aspects of p53 immunohistochemical staining. These include laboratory methods to optimize staining, a description of the different patterns of staining, advice regarding the interpretation, and reporting of p53 staining and practical uses of p53 staining in endometrial carcinoma diagnosis. Illustrations are provided to aid in the interpretational problems.
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Cites
Lehmann, S., Bykov, V. J. N., Ali, D., Andrén, O., Cherif, H., Tidefelt, U., Uggla, B., Yachnin, J., Juliusson, G., Moshfegh, A., et al. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2011.40.7783 · Cited by 406
Cited by
ESGO/ESTRO/ESP Guidelines for the Management of Patients with Endometrial Carcinoma
Concin, N., Matias-Guiu, X., Vergote, I., Cibula, D., Mirza, M. R., Marnitz, S., Ledermann, J., Bosse, T., Chargari, C., Fagotti, A., et al. (2021) · International Journal of Gynecological Cancer · doi:10.1136/ijgc-2020-002230 · Cited by 1,989
Singh, N., Piskorz, A. M., Bosse, T., Jimenez‐Linan, M., Rous, B., Brenton, J. D., Gilks, C. B., & Köbel, M. (2020) · The Journal of Pathology · doi:10.1002/path.5375 · Cited by 316
Self-citationIwatate, Y., Hoshino, I., Yokota, H., Ishige, F., Itami, M., Mori, Y., Chiba, S., Arimitsu, H., Yanagibashi, H., Nagase, H., et al. (2020) · British Journal of Cancer · doi:10.1038/s41416-020-0997-1 · Cited by 101
Praetorius, T. H., Leonova, A., Lac, V., Senz, J., Tessier-Cloutier, B., Nazeran, T. M., Köbel, M., Grube, M., Kraemer, B., Yong, P. J., et al. (2022) · Fertility and Sterility · doi:10.1016/j.fertnstert.2022.05.030 · Cited by 43
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Metadata
- Authors
- Köbel, M., Ronnett, B. M., Singh, N., Soslow, R. A., Gilks, C. B., & McCluggage, W. G.
- Venue
- International Journal of Gynecological Pathology
- Published
- 2019-01
- Volume
- 38
- Issue
- Supplement 1
- Pages
- S123-S131
- ISSN
- 0277-1691 (ISSN-L)
- OpenAlex
- W2793707558
- Cited by
- 408
- References
- 1
- FWCI
- 30.65
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Köbel, M., Ronnett, B. M., Singh, N., Soslow, R. A., Gilks, C. B., & McCluggage, W. G. (2019). Interpretation of P53 Immunohistochemistry in Endometrial Carcinomas: Toward Increased Reproducibility. International Journal of Gynecological Pathology. https://doi.org/10.1097/pgp.0000000000000488
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