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The Nocebo Effect and Its Relevance for Clinical Practice

Open access
Colloca, Luana, Miller, Franklin G.·2011·Psychosomatic Medicine
DOI 10.1097/psy.0b013e3182294a50
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Abstract

Negative expectations deriving from the clinical encounter can produce negative outcomes, known as nocebo effects. Specifically, research on the nocebo effect indicates that information disclosure about potential side effects can itself contribute to producing adverse effects. Neurobiological processes play a role in the nocebo effect, and this article provides a selective review of mechanistic research on the nocebo effect. Comparatively little attention has been directed to clinical studies and their implications for daily clinical practice. The nocebo response is influenced by the content and the way information is presented to patients in clinical trials in both the placebo and active treatment conditions. Nocebo effects adversely influence quality of life and therapy adherence, emphasizing the need for minimizing these responses to the extent possible. Evidence further indicates that the informed consent process in clinical trials may induce nocebo effects. This article concludes with ethical directions for future patient-oriented research and routine practice.

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Research works printed but not linked: 45

  1. Enck, 2008, New insights into the placebo and nocebo responses., Neuron, 59, 195, 10.1016/j.neuron.2008.06.030 · DOI · Paper page
  2. Myers, 1987, The consent form as a possible cause of side effects., Clin Pharmacol Ther, 42, 250, 10.1038/clpt.1987.142 · DOI · Paper page
  3. Flaten, 1999, Drug-related information generates placebo and nocebo responses that modify the drug response., Psychosom Med, 61, 250, 10.1097/00006842-199903000-00018 · DOI · Paper page
  4. Lancman, 1994, Predictive value of induction of psychogenic seizures by suggestion., Ann Neurol, 35, 359, 10.1002/ana.410350319 · DOI
  5. Luparello, 1970, The interaction of psychologic stimuli and pharmacologic agents on airway reactivity in asthmatic subjects., Psychosom Med, 32, 509, 10.1097/00006842-197009000-00009 · DOI
  6. Mondaini, 2007, Finasteride 5 mg and sexual side effects: how many of these are related to a nocebo phenomenon?, J Sex Med, 4, 1708, 10.1111/j.1743-6109.2007.00563.x · DOI · Paper page
  7. Colloca, 2004, Overt versus covert treatment for pain, anxiety, and Parkinson's disease., Lancet Neurol, 3, 679, 10.1016/S1474-4422(04)00908-1 · DOI · Paper page
  8. Miller, 2008, The power of context: reconceptualizing the placebo effect., J R Soc Med, 101, 222, 10.1258/jrsm.2008.070466 · DOI · Paper page
  9. Lamont, 2003, Complexities in prognostication in advanced cancer: "to help them live their lives the way they want to"., JAMA, 290, 98, 10.1001/jama.290.1.98 · DOI · Paper page
  10. Sakala, 2007, Letter from North America: understanding and minimizing nocebo effects in childbearing women., Birth, 34, 348, 10.1111/j.1523-536X.2007.00196.x · DOI
  11. Grimes, 2011, Nonspecific side effects of oral contraceptives: nocebo or noise?, Contraception, 83, 5, 10.1016/j.contraception.2010.06.010 · DOI
  12. Kennedy, 1961, The nocebo reaction., Med World, 95, 203
  13. Ernst, 1995, Concept of true and perceived placebo effects., BMJ, 311, 551, 10.1136/bmj.311.7004.551 · DOI · Paper page
  14. van Laarhoven, 2011, Induction of nocebo and placebo effects on itch and pain by verbal suggestions., Pain, 152, 1486, 10.1016/j.pain.2011.01.043 · DOI · Paper page
  15. Colloca, 2008, The role of learning in nocebo and placebo effects., Pain, 136, 211, 10.1016/j.pain.2008.02.006 · DOI · Paper page
  16. Mazzoni, 2010, The effects of observation and gender on psychogenic symptoms., Health Psychol, 29, 181, 10.1037/a0017860 · DOI
  17. Oftedal, 2007, Mobile phone headache: a double blind, sham-controlled provocation study., Cephalalgia, 27, 447, 10.1111/j.1468-2982.2007.01336.x · DOI
  18. Stovner, 2008, Nocebo as headache trigger: evidence from a sham-controlled provocation study with RF fields., Acta Neurol Scand Suppl, 188, 67, 10.1111/j.1600-0404.2008.01035.x · DOI
  19. Dworkin, 1983, Cognitive reversal of expected nitrous oxide analgesia for acute pain., Anesth Analg, 62, 1073, 10.1213/00000539-198312000-00005 · DOI
  20. Rodriguez-Raecke, 30, Insular cortex activity is associated with effects of negative expectation on nociceptive long-term habituation., J Neurosci, 11363-, 8
  21. Doganci, 2011, Expectations modulate long-term heat pain habituation., Eur J Pain, 15, 384, 10.1016/j.ejpain.2010.09.003 · DOI
  22. Amanzio, 2009, A systematic review of adverse events in placebo groups of anti-migraine clinical trials., Pain, 146, 261, 10.1016/j.pain.2009.07.010 · DOI · Paper page
  23. Reuter, 2003, Placebo adverse events in headache trials: headache as an adverse event of placebo., Cephalalgia, 23, 496, 10.1046/j.1468-2982.2003.00530.x · DOI
  24. Cairns, 1985, Aspirin, sulfinpyrazone, or both in unstable angina. Results of a Canadian multicenter trial., N Engl J Med, 313, 1369, 10.1056/NEJM198511283132201 · DOI · Paper page
  25. Cocco, 2009, Erectile dysfunction after therapy with metoprolol: the Hawthorne effect., Cardiology, 112, 174, 10.1159/000147951 · DOI
  26. Silvestri, 2003, Report of erectile dysfunction after therapy with beta-blockers is related to patient knowledge of side effects and is reversed by placebo., Eur Heart J, 24, 1928, 10.1016/j.ehj.2003.08.016 · DOI · Paper page
  27. Varelmann, 2010, Nocebo-induced hyperalgesia during local anesthetic injection., Anesth Analg, 110, 868, 10.1213/ANE.0b013e3181cc5727 · DOI · Paper page
  28. Taddio, 2002, Conditioning and hyperalgesia in newborns exposed to repeated heel lances., JAMA, 288, 857, 10.1001/jama.288.7.857 · DOI · Paper page
  29. Liccardi, 2004, Evaluation of the nocebo effect during oral challenge in patients with adverse drug reactions., J Investig Allergol Clin Immunol, 14, 104
  30. Lombardi, 2008, The nocebo effect during oral challenge in subjects with adverse drug reactions., Eur Ann Allergy Clin Immunol, 40, 138
  31. Colagiuri, 2010, Patient expectancy and post-chemotherapy nausea: a meta-analysis., Ann Behav Med, 40, 3, 10.1007/s12160-010-9186-4 · DOI
  32. de la Cruz, 2010, Placebo and nocebo effects in randomized double-blind clinical trials of agents for the therapy for fatigue in patients with advanced cancer., Cancer, 116, 766, 10.1002/cncr.24751 · DOI
  33. Bovbjerg, 1992, An experimental analysis of classically conditioned nausea during cancer chemotherapy., Psychosom Med, 54, 623, 10.1097/00006842-199211000-00001 · DOI
  34. Roscoe, 2010, An exploratory study on the effects of an expectancy manipulation on chemotherapy-related nausea., J Pain Symptom Manage, 40, 379, 10.1016/j.jpainsymman.2009.12.024 · DOI
  35. Shelke, 2008, Effect of a nausea expectancy manipulation on chemotherapy-induced nausea: a University of Rochester Cancer Center community clinical oncology program study., J Pain Symptom Manage, 35, 381, 10.1016/j.jpainsymman.2007.05.008 · DOI
  36. Stockhorst, 1998, Effects of overshadowing on conditioned nausea in cancer patients: an experimental study., Physiol Behav, 64, 743, 10.1016/S0031-9384(98)00135-8 · DOI
  37. Miller, 2011, The placebo phenomenon and medical ethics: rethinking the relationship between informed consent and risk-benefit assessment., Theor Med Bioeth, 32, 229, 10.1007/s11017-011-9179-8 · DOI
  38. Edwards, 2001, Presenting risk information-a review of the effects of "framing" and other manipulations on patient outcomes., J Health Commun, 6, 61, 10.1080/10810730150501413 · DOI · Paper page
  39. O'Connor, 1996, Framing effects on expectations, decisions, and side effects experienced: the case of influenza immunization., J Clin Epidemiol, 49, 1271, 10.1016/S0895-4356(96)00177-1 · DOI · Paper page
  40. Egbert, 1964, Reduction of postoperative pain by encouragement and instruction of patients. A study of doctor-patient rapport., N Engl J Med, 270, 825, 10.1056/NEJM196404162701606 · DOI · Paper page
  41. Gracely, 1985, Clinicians' expectations influence placebo analgesia., Lancet, 1, 43, 10.1016/S0140-6736(85)90984-5 · DOI · Paper page
  42. Greenfield, 1985, Expanding patient involvement in care. Effects on patient outcomes., Ann Intern Med, 102, 520, 10.7326/0003-4819-102-4-520 · DOI · Paper page
  43. Kaplan, 1989, Assessing the effects of physician-patient interactions on the outcomes of chronic disease., Med Care, 27, S110, 10.1097/00005650-198903001-00010 · DOI · Paper page
  44. Brewin, 1991, Three ways of giving bad news., Lancet, 337, 1207, 10.1016/0140-6736(91)92870-8 · DOI
  45. Petrie, 2007, Effect of providing information about normal test results on patients' reassurance: randomised controlled trial., BMJ, 334, 352, 10.1136/bmj.39093.464190.55 · DOI

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Metadata

Authors
Colloca, L., & Miller, F. G.
Venue
Psychosomatic Medicine
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2011-09
Volume
73
Issue
7
Pages
598-603
ISSN
0033-3174 (ISSN-L)
DOI
10.1097/psy.0b013e3182294a50
OpenAlex
W2167418359
Cited by
419
References
10
FWCI
8.89
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: The Nocebo Effect and Its Relevance for Clinical Practice. https://app.cochat.ai/papers/10.1097/psy.0b013e3182294a50
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Colloca, L., & Miller, F. G. (2011). The Nocebo Effect and Its Relevance for Clinical Practice. Psychosomatic Medicine. https://doi.org/10.1097/psy.0b013e3182294a50

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