The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Effects of Exercise Training on Fatigue in Multiple Sclerosis: A Meta-Analysis
Abstract
OBJECTIVE: To provide a quantitative synthesis of randomized controlled trials examining the effect of exercise training on symptomatic fatigue in persons with multiple sclerosis (MS). METHODS: Electronic databases (Web of Science, PubMed, PsycInfo, and Google Scholar) were searched for articles published between 1960 and October 2012 by using the key words "fatigue," OR "tiredness," OR "energy," OR "mood," OR "lassitude," AND "exercise," OR "physical activity," OR "rehabilitation," OR "fitness" WITH "multiple sclerosis." The initial search resulted in 311 articles, of which 74 were reviewed in detail and 17 met the inclusion criteria and provided enough data to compute effect sizes (ESs; Cohen d). The meta-analysis was conducted using a meta-analysis software program, and a random-effects model was used to calculate the overall ES, expressed as Hedge g. RESULTS: The weighted mean ES from 17 randomized controlled trials with 568 participants with MS was 0.45 (standard error = 0.12, 95% confidence interval = 0.22-0.68, z = 3.88, p ≤ .001). The weighted mean ES was slightly heterogeneous (Q = 29.9, df = 16, p = .019). CONCLUSIONS: The cumulative evidence supports that exercise training is associated with a significant small reduction in fatigue among persons with MS.
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Cites
(1985) · Europe PMC (PubMed Central) · Cited by 9,143
Reliability of the PEDro Scale for Rating Quality of Randomized Controlled Trials
Maher, C. G., Sherrington, C., Herbert, R. D., Moseley, A. M., & Elkins, M. (2003) · Physical Therapy · doi:10.1093/ptj/83.8.713 · Cited by 4,808
Impact of aerobic training on fitness and quality of life in multiple sclerosis
Petajan, J. H., Gappmaier, E., White, A. T., Spencer, M. K., Mino, L., & Hicks, R. W. (1996) · Annals of Neurology · doi:10.1002/ana.410390405 · Cited by 757
Randomized controlled trial of yoga and exercise in multiple sclerosis
Oken, B. S., Kishiyama, S., Zajdel, D., Bourdette, D., Carlsen, J., Haas, M., Hugos, C., Kraemer, D. F., Lawrence, J., & Mass, M. (2004) · Neurology · doi:10.1212/01.wnl.0000129534.88602.5c · Cited by 593
Physical activity and multiple sclerosis: a meta-analysis
Motl, R. W., McAuley, E., & Snook, E. M. (2005) · Multiple Sclerosis Journal · doi:10.1191/1352458505ms1188oa · Cited by 516
Self-citationImpact of Walking Impairment in Multiple Sclerosis: Perspectives of Patients and Care Partners
LaRocca, N. G. (2011) · The Patient: Patient-Centered Outcomes Research · doi:10.2165/11591150-000000000-00000 · Cited by 507
Mostert, S., & Kesselring, J. (2002) · Multiple Sclerosis Journal · doi:10.1191/1352458502ms779oa · Cited by 500
Dalgas, U., Stenager, E., & Ingemann-Hansen, T. (2008) · Multiple Sclerosis Journal · doi:10.1177/1352458507079445 · Cited by 440
Fatigue in Multiple Sclerosis: Mechanisms, Evaluation, and Treatment
Braley, T. J., & Chervin, R. D. (2010) · Sleep · doi:10.1093/sleep/33.8.1061 · Cited by 403
Effect of Exercise Training on Walking Mobility in Multiple Sclerosis: A Meta-Analysis
Snook, E. M., & Motl, R. W. (2009) · Neurorehabilitation and Neural Repair · doi:10.1177/1545968308320641 · Cited by 374
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Exercise in patients with multiple sclerosis
Motl, R. W., Sandroff, B. M., Kwakkel, G., Dalgas, U., Feinstein, A., Heesen, C., Feys, P., & Thompson, A. J. (2017) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30281-8 · Cited by 451
Self-citationRandomised controlled trial of a self-guided online fatigue intervention in multiple sclerosis
Pöttgen, J., Moss-Morris, R., Wendebourg, J.-M., Feddersen, L., Lau, S., Köpke, S., Meyer, B., Friede, T., Penner, I.-K., Heesen, C., et al. (2018) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2017-317463 · Cited by 129
McGuire, K. B., Stojanovic-Radic, J., Strober, L., Chiaravalloti, N. D., & DeLuca, J. (2015) · International Journal of MS Care · doi:10.7224/1537-2073.2013-045 · Cited by 30
Sesel, A.-L., Sharpe, L., Beadnall, H. N., Barnett, M. H., Szabo, M., & Naismith, S. L. (2022) · Multiple Sclerosis Journal · doi:10.1177/13524585211068002 · Cited by 22
Metadata
- Authors
- Pilutti, L. A., Greenlee, T. A., Motl, R. W., Nickrent, M. S., & Petruzzello, S. J.
- Venue
- Psychosomatic Medicine
- Published
- 2013-07
- Volume
- 75
- Issue
- 6
- Pages
- 575-580
- ISSN
- 0033-3174 (ISSN-L)
- OpenAlex
- W1967860258
- Cited by
- 271
- References
- 45
- FWCI
- 12.67
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Effects of Exercise Training on Fatigue in Multiple Sclerosis: A Meta-Analysis. https://app.cochat.ai/papers/10.1097/psy.0b013e31829b4525
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- Pilutti, L. A., Greenlee, T. A., Motl, R. W., Nickrent, M. S., & Petruzzello, S. J. (2013). Effects of Exercise Training on Fatigue in Multiple Sclerosis: A Meta-Analysis. Psychosomatic Medicine. https://doi.org/10.1097/psy.0b013e31829b4525
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
