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Cited by 388

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Role of viral replication, antiretroviral therapy, and immunodeficiency in HIV-associated atherosclerosis

Open access
Hsue, Priscilla Y, Hunt, Peter W, Schnell, Amanda, Kalapus, S Craig, Hoh, Rebecca, Ganz, Peter, Martin, Jeffrey N, Deeks, Steven G·2009·AIDS
DOI 10.1097/qad.0b013e32832b514b
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Abstract

OBJECTIVE: HIV-seropositive patients are at higher risk for atherosclerosis than HIV-seronegative persons. This has been variably attributed to antiretroviral drug toxicity, immunodeficiency, and/or HIV-associated inflammation. To evaluate the contributions of these factors to HIV-associated atherosclerosis, we assessed carotid artery intima-media thickness in a diverse cohort of HIV-seronegative and seropositive adults, including a unique group of HIV-infected patients who were untreated, had undetectable viral loads, and had preserved CD4 T-cell counts (HIV controllers). METHODS AND RESULTS: Carotid intima-media thickness was measured in 494 participants, including 33 HIV controllers and 93 HIV-seronegative controls. HIV controllers had higher intima-media thickness than seronegative controls even after adjustment for traditional risk factors (P = 0.003). Intima-media thickness in controllers was similar to antiretroviral-untreated patients with detectable viremia. Across all participants, intima-media thickness was strongly associated with the presence of HIV disease rather than viral load or CD4 T-cell count. C-reactive protein was higher in HIV controllers than HIV-seronegative persons. Antiretroviral drug exposure was also associated with higher intima-media thickness. CONCLUSIONS: Increased atherosclerosis with HIV infection can occur in the absence of antiretroviral therapy, detectable viremia, or overt immunodeficiency. Chronic inflammation - which is higher in controllers than in HIV-uninfected persons - may account for early atherosclerosis in these patients.

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Metadata

Authors
Hsue, P. Y., Hunt, P. W., Schnell, A., Kalapus, S. C., Hoh, R., Ganz, P., Martin, J. N., & Deeks, S. G.
Venue
AIDS
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2009-06-01
Volume
23
Issue
9
Pages
1059-1067
ISSN
0269-9370 (ISSN-L)
DOI
10.1097/qad.0b013e32832b514b
OpenAlex
W2068400385
Cited by
388
References
40
FWCI
38.39
Type
journal article
Language
en
Open access
green

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