Cited by 43HIV/AIDS Research and InterventionsGlobal Maternal and Child HealthHIV/AIDS drug development and treatment

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Mother-to-Child Transmission of HIV in Kenya: Results From a Nationally Representative Study

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Sirengo, Martin, Muthoni, Lilly, Kellogg, Timothy A., A. Kim, Andrea, Katana, Abraham, Mwanyumba, Sophie, Kimanga, Davies O., Maina, William K., Muraguri, Nicolas, Elly, Benjamin, Rutherford, George W.·2014·JAIDS Journal of Acquired Immune Deficiency Syndromes

Abstract

BACKGROUND: Kenya has an estimated 13,000 new infant HIV infections that occur annually. We measured the burden of HIV infection among women of childbearing age and assessed access to and coverage of key prevention of mother-to-child transmission interventions. METHODS: The second Kenya AIDS Indicator Survey was a nationally representative 2-stage cluster sample of households. We analyzed data from women aged 15-54 years who had delivered a newborn within the preceding 5 years and from whom we obtained samples for HIV testing. RESULTS: Of 3310 women who had ≥1 live birth in the preceding 5 years, 2862 (86.5%) consented to HIV testing in the survey, and 171 (6.1%) were found to be infected. Ninety-five percent received prenatal care, 93.1% were screened for HIV during prenatal care, and of those screened, 97.8% received their test results. Seventy-six women were known to be infected in their last pregnancy. Of these, 54 (72.3%) received antepartum antiretroviral prophylaxis, and 51 (69.1%) received intrapartum prophylaxis; 56 (75.3%) reported their newborns received postpartum prophylaxis. Of the 76 children born to these mothers, 63 (82.5%) were tested for HIV at the first immunization visit or thereafter, and 8 (15.1%) were HIV infected. CONCLUSIONS: We found a substantial burden of HIV in Kenyan women of childbearing age and a cumulative 5-year mother-to-child transmission rate of 15%. Although screening has improved over the past 5 years, fewer than three-quarters of infected pregnant women are receiving antiretroviral prophylaxis. Universal antiretroviral therapy for HIV-infected pregnant women will be essential in achieving Kenyan's target to eliminate mother-to-child transmission to <5% by 2015.

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Metadata

Authors
Sirengo, M., Muthoni, L., Kellogg, T. A., A. Kim, A., Katana, A., Mwanyumba, S., Kimanga, D. O., Maina, W. K., Muraguri, N., Elly, B., & Rutherford, G. W.
Affiliations
  • Centers for Disease Control and Prevention (US)
  • University of California, San Francisco (US)
  • Ministry of Health (KE)
Corresponding author
  • Sirengo, Martin
  • Kimanga, Davies O.
  • Maina, William K.
  • Muraguri, Nicolas
Venue
JAIDS Journal of Acquired Immune Deficiency Syndromes
Published
2014-05-01
Volume
66
Issue
Supplement 1
Pages
S66-S74
ISSN
1525-4135 (ISSN-L)
OpenAlex
W2072622199
Cited by
43
References
4
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2023: 4 · 2022: 2 · 2021: 5 · 2020: 4 · 2019: 6 · 2018: 6 · 2017: 4 · 2016: 2 · 2015: 2 · 2014: 4
FWCI
2.80
Type
journal article
Language
en
Open access
Locations
  • JAIDS Journal of Acquired Immune Deficiency Syndromes (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (CC999999)
  • Centers for Disease Control and Prevention (U19GH000069)
  • National Institute of Mental Health (P30MH062246)
Topics
  • Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Global Maternal and Child Health
  • Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
Keywords
mother-to-child transmission, HIV, pregnant women, women of reproductive age, antenatal HIV testing, antiretroviral prophylaxis, infant HIV testing, Kenya, prevention of mother-to-child transmission, HIV prevalence
MeSH terms
Adolescent, Adult, Age Factors, Cross-Sectional Studies, Female, Health Surveys, HIV Seropositivity, Humans, Infant, Newborn, Kenya, Health Knowledge, Attitudes, Practice, Middle Aged, Pregnancy, Pregnancy Trimesters, Prenatal Care, Prevalence, Infectious Disease Transmission, Vertical, Perinatal Care, Anti-Retroviral Agents, Live Birth, Young Adult

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