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Long-Term Mortality in HIV-Infected Individuals 50 Years or Older: A Nationwide, Population-Based Cohort Study

Legarth, Rebecca A., Ahlström, Magnus G., Kronborg, Gitte, Larsen, Carsten S., Pedersen, Court, Pedersen, Gitte, Mohey, Rajesh, Gerstoft, Jan, Obel, Niels·2016·JAIDS Journal of Acquired Immune Deficiency Syndromes

DOI 10.1097/qai.0000000000000825

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Abstract

BACKGROUND: Although the prevalence of HIV-infection among individuals ≥ 50 years of age has increased, the impact of HIV-infection on risk of death in this population remains to be established. Our aim was to estimate long-term mortality among HIV-infected individuals who were 50 years or older, when compared with an individually-matched cohort from the background population. METHODS: Population-based cohort-study including HIV-infected individuals ≥ 50 years, who were alive 1 year after HIV-diagnosis (n = 2440) and a comparison cohort individually-matched by age and gender extracted from the background population (n = 14,588). Cumulative survival was evaluated using Kaplan-Meier method and Mortality Rate Ratios (MRRs) were estimated using Cox Regression Models. Study period 1996-2014. RESULTS: Estimated median survival time from age 50 years for HIV-infected individuals increased from 11.8 years (95% CI: 10.2 to 14.5) during 1996-1999 to 22.8 years (20.0-24.2) in 2006-2014. MRR decreased with increasing age from 3.8 (3.1-4.7) for 50-55 years to 1.6 (1.0-2.6) for 75-80 years. In a cohort of well-treated HIV-infected individuals ≥ 50 years without AIDS-defining events or comorbidity at study inclusion (n = 517). MRR was 1.7 (1.2-2.3) compared with population controls without comorbidity. CONCLUSION: Among HIV-infected individuals estimated median survival time from age 50 years has increased by more than 10 years from 1996-1999 to 2006-2014, but is still substantially lower than in the background population. Even among well-treated HIV-infected individuals ≥ 50 years without comorbidity or AIDS-defining events the estimated median survival time remains lower than in the general population.

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Authors: Legarth, R. A., Ahlström, M. G., Kronborg, G., Larsen, C. S., Pedersen, C., Pedersen, G., Mohey, R., Gerstoft, J., & Obel, N.
Affiliations: Aalborg University Hospital (DK)
Copenhagen University Hospital (DK)
Hvidovre Hospital (DK)
Aarhus University Hospital (DK)
Odense University Hospital (DK)
Regionshospitalet Herning (DK)
Corresponding author: Legarth, Rebecca A.
Ahlström, Magnus G.
Gerstoft, Jan
Obel, Niels
ORCID: Ahlström, Magnus G.
Kronborg, Gitte
Larsen, Carsten S.
Pedersen, Gitte
Mohey, Rajesh
Gerstoft, Jan
Obel, Niels
Venue: JAIDS Journal of Acquired Immune Deficiency Syndromes
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2016-02-01
Volume: 71
Issue: 2
Pages: 213-218
ISSN: 1525-4135 (ISSN-L)
DOI: 10.1097/qai.0000000000000825
OpenAlex: W1555146734
Cited by: 121
References: 22
Citations by year: 2026: 2 · 2025: 5 · 2024: 11 · 2023: 10 · 2022: 12 · 2021: 13 · 2020: 16 · 2019: 12 · 2018: 14 · 2017: 13 · 2016: 12
FWCI: 10.10
Type: journal article
Language: en
Open access: closed
Locations: JAIDS Journal of Acquired Immune Deficiency Syndromes (publishedVersion)
PubMed (publishedVersion)
University of Southern Denmark Research Portal (University of Southern Denmark) (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
VBN Forskningsportal (Aalborg Universitet) (submittedVersion)
Topics: Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
Health Sciences › Medicine › Infectious Diseases › HIV-related health complications and treatments
Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Keywords: HIV infection, long-term mortality, older adults, age 50 and over, survival time, mortality rate ratio, antiretroviral therapy, comorbidities, AIDS-defining events, aging with HIV
MeSH terms: Aged, Aged, 80 and over, Cause of Death, Denmark, Female, Humans, Male, Middle Aged, Research Design, Cohort Studies, HIV Infections, Comorbidity, Proportional Hazards Models, Kaplan-Meier Estimate

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Long-Term Mortality in HIV-Infected Individuals 50 Years or Older: A Nationwide, Population-Based Cohort Study

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