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Cited by 748HIV/AIDS Research and InterventionsHIV-related health complications and treatmentsHIV, Drug Use, Sexual Risk

. Survival of persons with and without HIV infection in Denmark, 1995-2005.

Lohse, Nicolai, Hansen, Ann-Brit Eg, Pedersen, Gitte, Kronborg, Gitte, Gerstoft, Jan, Sørensen, Henrik Toft, Væth, Michael, Obel, Niels·2007·Annals of Internal Medicine
DOI 10.7326/0003-4819-146-2-200701160-00003
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Abstract

BACKGROUND: The expected survival of HIV-infected patients is of major public health interest. OBJECTIVE: To estimate survival time and age-specific mortality rates of an HIV-infected population compared with that of the general population. DESIGN: Population-based cohort study. SETTING: All HIV-infected persons receiving care in Denmark from 1995 to 2005. PATIENTS: Each member of the nationwide Danish HIV Cohort Study was matched with as many as 99 persons from the general population according to sex, date of birth, and municipality of residence. MEASUREMENTS: The authors computed Kaplan-Meier life tables with age as the time scale to estimate survival from age 25 years. Patients with HIV infection and corresponding persons from the general population were observed from the date of the patient's HIV diagnosis until death, emigration, or 1 May 2005. RESULTS: 3990 HIV-infected patients and 379,872 persons from the general population were included in the study, yielding 22,744 (median, 5.8 y/person) and 2,689,287 (median, 8.4 years/person) person-years of observation. Three percent of participants were lost to follow-up. From age 25 years, the median survival was 19.9 years (95% CI, 18.5 to 21.3) among patients with HIV infection and 51.1 years (CI, 50.9 to 51.5) among the general population. For HIV-infected patients, survival increased to 32.5 years (CI, 29.4 to 34.7) during the 2000 to 2005 period. In the subgroup that excluded persons with known hepatitis C coinfection (16%), median survival was 38.9 years (CI, 35.4 to 40.1) during this same period. The relative mortality rates for patients with HIV infection compared with those for the general population decreased with increasing age, whereas the excess mortality rate increased with increasing age. LIMITATIONS: The observed mortality rates are assumed to apply beyond the current maximum observation time of 10 years. CONCLUSIONS: The estimated median survival is more than 35 years for a young person diagnosed with HIV infection in the late highly active antiretroviral therapy era. However, an ongoing effort is still needed to further reduce mortality rates for these persons compared with the general population.

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  • HIV infection accelerates aging, and illnesses typical of the elderly are highly frequent among HIV-infected individuals even when therapy suppresses the virus below detection limits.

    “There is an emerging consensus in the scientific community that HIV infection hastens the process of aging and that illnesses that appear typically in the elderly are highly frequent among HIV-infected individuals, even in those with therapy-induced suppression of the virus below detection limits [59,60].”

    From T-cell aging in rheumatoid arthritis (2014) · cites this paper as [59]

  • Compared to behaviorally and demographically similar HIV-uninfected individuals, people with HIV infection, even those receiving effective ART with suppression of virus to levels below typical detection limits, experience excess morbidity and mortality.

    “When compared to behaviorally and demographically similar HIV-uninfected individuals, people with HIV infection, even those receiving effective ART with suppression of virus to levels below typical detection limits, experience excess morbidity and mortality (3,4).”

    From HIV and Aging: State of Knowledge and Areas of Critical Need for Research. A Report to the NIH Office of AIDS Research by the HIV and Aging Working Group (2012) · cites this paper as [3]

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Authors
Lohse, N., Hansen, A.-B. E., Pedersen, G., Kronborg, G., Gerstoft, J., Sørensen, H. T., Væth, M., & Obel, N.
Affiliations
Boston University (US)
ORCID
Venue
Annals of Internal Medicine
Publisher
American College of Physicians
Published
2007-01-16
Volume
146
Issue
2
Pages
87-95
ISSN
  • 0003-4819 (ISSN-L)
  • 1539-3704
DOI
10.7326/0003-4819-146-2-200701160-00003
OpenAlex
W1967548282
Cited by
748
References
21
Citations by year
2026: 3 · 2025: 8 · 2024: 15 · 2023: 9 · 2022: 14 · 2021: 17 · 2020: 19 · 2019: 15 · 2018: 34 · 2017: 32 · 2016: 44 · 2015: 54 · 2014: 62 · 2013: 75 · 2012: 73
FWCI
39.70
Type
journal article
Language
en
Open access
closed
Licence
www.acpjournals.org/journal/aim/text-and-data-mining (tdm)
Locations
  • Annals of Internal Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
  • University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
  • Health Sciences › Medicine › Emergency Medicine › HIV-related health complications and treatments
  • Health Sciences › Medicine › Epidemiology › HIV, Drug Use, Sexual Risk
Keywords
HIV infection, survival, mortality, age-specific mortality, excess mortality, hepatitis C coinfection, highly active antiretroviral therapy, HIV cohort, Denmark, life tables, HIV treatment outcomes
MeSH terms
Adult, Cause of Death, Denmark, Female, Hepatitis C, Humans, Life Expectancy, Male, Middle Aged, Prospective Studies, HIV Infections, Survival Rate, Case-Control Studies, Antiretroviral Therapy, Highly Active

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