The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Estimating the Lost Benefits of Antiretroviral Drug Use in South Africa
Abstract
South Africa is one of the countries most severely affected by HIV/AIDS. At the peak of the epidemic, the government, going against consensus scientific opinion, argued that HIV was not the cause of AIDS and that antiretroviral (ARV) drugs were not useful for patients and declined to accept freely donated nevirapine and grants from the Global Fund. Using modeling, we compared the number of persons who received ARVs for treatment and prevention of mother-to-child HIV transmission between 2000 and 2005 with an alternative of what was reasonably feasible in the country during that period. More than 330,000 lives or approximately 2.2 million person-years were lost because a feasible and timely ARV treatment program was not implemented in South Africa. Thirty-five thousand babies were born with HIV resulting in 1.6 million person-years lost by not implementing a mother-to-child transmission prophylaxis program using nevirapine. The total lost benefits of ARVs are at least 3.8 million person-years for the period 2000-2005.
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Cites
The Efficacy of Azidothymidine (AZT) in the Treatment of Patients with AIDS and AIDS-Related Complex
Fischl, M. A., Richman, D. D., Grieco, M. H., Gottlieb, M. S., Volberding, P. A., Laskin, O. L., Leedom, J. M., Groopman, J. E., Mildvan, D., Schooley, R. T., et al. (1987) · New England Journal of Medicine · doi:10.1056/nejm198707233170401 · Cited by 2,995
The Toxicity of Azidothymidine (AZT) in the Treatment of Patients with AIDS and AIDS-Related Complex
Richman, D. D., Fischl, M. A., Grieco, M. H., Gottlieb, M. S., Volberding, P. A., Laskin, O. L., Leedom, J. M., Groopman, J. E., Mildvan, D., Hirsch, M. S., et al. (1987) · New England Journal of Medicine · doi:10.1056/nejm198707233170402 · Cited by 1,199 · cited 1×
“ZDV was tested for AIDS treatment in controlled randomized clinical trials,(9) and its side effects were clearly documented and disclosed.(10) Later studies showed that in combination with other drugs, therapy was very efficacious, resulting in the name highly active antiretroviral therapy for triple-drug cocktails.”
Background
Cited by
Cook, J., Lewandowsky, S., & Ecker, U. K. H. (2017) · PLOS ONE · doi:10.1371/journal.pone.0175799 · Cited by 971
Health and Health Care in South Africa — 20 Years after Mandela
Mayosi, B. M., & Benatar, S. R. (2014) · New England Journal of Medicine · doi:10.1056/nejmsr1405012 · Cited by 533
The pivotal role of perceived scientific consensus in acceptance of science
Lewandowsky, S., Gignac, G. E., & Vaughan, S. (2013) · Nature Climate Change · doi:10.1038/nclimate1720 · Cited by 527
Belief in conspiracy theories: Basic principles of an emerging research domain
van Prooijen, J., & Douglas, K. M. (2018) · European Journal of Social Psychology · doi:10.1002/ejsp.2530 · Cited by 483
Effective strategies for rebutting science denialism in public discussions
Schmid, P., & Betsch, C. (2019) · Nature Human Behaviour · doi:10.1038/s41562-019-0632-4 · Cited by 264
Metadata
- Authors
- Chigwedere, P., Seage, G. R., Gruskin, S., Lee, T.-H., & Essex, M.
- Venue
- JAIDS Journal of Acquired Immune Deficiency Syndromes
- Published
- 2008-12-01
- Volume
- 49
- Issue
- 4
- Pages
- 410-415
- ISSN
- 1525-4135 (ISSN-L)
- OpenAlex
- W2037112928
- Cited by
- 413
- References
- 2
- FWCI
- 12.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chigwedere, P., Seage, G. R., Gruskin, S., Lee, T.-H., & Essex, M. (2008). Estimating the Lost Benefits of Antiretroviral Drug Use in South Africa. JAIDS Journal of Acquired Immune Deficiency Syndromes. https://doi.org/10.1097/qai.0b013e31818a6cd5
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