The DOI matches its Crossref record; 20 of the 21 references it cites were found in a registry or an index.
Peer Support and Pager Messaging to Promote Antiretroviral Modifying Therapy in Seattle: A Randomized Controlled Trial
Open accessAbstract
OBJECTIVE: To determine the relative efficacy of peer support and pager messaging strategies versus usual care to improve medication adherence and clinical outcomes among HIV-positive outpatients initiating or switching to a new highly active antiretroviral therapy regimen. DESIGN: A 2 3 2 factorial randomized controlled trial of a 3-month intervention with computer-assisted self-interviews and blood draws administered at baseline, 3, 6, and 9 months. METHODS: HIV-positive patients at a public HIV specialty clinic in Seattle,WA (N = 224) were randomly assigned to peer support, pager messaging, both strategies, or usual care. The main outcomes were adherence according to self-report and electronic drug monitoring, CD4 count, and HIV-1 RNA viral load. RESULTS: Intent-to-treat analyses suggested the peer intervention was associated with greater self-reported adherence at immediate postintervention. However, these effects were not maintained at follow-up assessment; nor were there significant differences in biological outcomes. The pager intervention, on the other hand, was not associated with greater adherence but was associated with improved biological outcomes at postintervention that were sustained at follow-up. CONCLUSIONS: Analyses indicate the potential efficacy of peer support and pager messaging to promote antiretroviral adherence and biological outcomes, respectively. More potent strategies still are needed.
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“This intervention, however, failed to produce significant improvements in adherence over the 9-month trial relative to usual care or peer support”
From Health behavior models in the age of mobile interventions: are our theories up to the task? (2011) · cites this paper as [55]
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Cites
Longitudinal data analysis using generalized linear models
LIANG, K.-Y., & ZEGER, S. L. (1986) · Biometrika · doi:10.1093/biomet/73.1.13 · Cited by 18,550
Mills, E. J., Nachega, J. B., Bangsberg, D. R., Singh, S., Rachlis, B., Wu, P., Wilson, K., Buchan, I., Gill, C. J., & Cooper, C. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030438 · Cited by 818 · cited 1×
“However, in both resource-rich and resource-constrained settings, the majority of patients on HAART struggle to maintain optimal levels of adherence.(5,6) Two meta-analyses indicated that various behavioral strategies can be efficacious in promoting adherence and improving clinical outcomes.”
BackgroundSimoni, J. M., Kurth, A., Pearson, C. R., Pantalone, D. W., Merrill, J. O., & Frick, P. A. (2006) · AIDS and Behavior · doi:10.1007/s10461-006-9078-6 · Cited by 653 · cited 1×
“A dichotomous variable for past week 100% adherence was created with participants classified as perfectly adherent if they missed zero doses and nonadherent if they missed 1 or more doses.(10,15) We computed a continuous EDM adherence variable, defined as the number of bottle openings recorded by the Medication Event…”
MethodSelf-citationThe Survival Benefits of AIDS Treatment in the United States
Walensky, R. P., Paltiel, A. D., Losina, E., Mercincavage, L. M., Schackman, B. R., Sax, P. E., Weinstein, M. C., & Freedberg, K. A. (2006) · The Journal of Infectious Diseases · doi:10.1086/505147 · Cited by 580 · cited 1×
“0 million years of life in the United States alone.(3) Consistent strict adherence remains key to successful viral suppression.”
BackgroundKnobel, H., Alonso, J., Casado, J. L., Collazos, J., González, J. M., Ruíz-Camps, I., Kindelán, J. M., Carmona, A., Juega, J., & Ocampo, A. (2002) · AIDS · doi:10.1097/00002030-200203080-00012 · Cited by 486
Comparisons of Causes of Death and Mortality Rates Among HIV-Infected Persons
Crum, N. F., Riffenburgh, R. H., Wegner, S. A., Agan, B. K., Tasker, S. A., Spooner, K., Armstrong, A. W., Fraser, S. L., & Wallace, M. R. (2006) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/01.qai.0000179459.31562.16 · Cited by 456
Simoni, J. M., Pearson, C. R., Pantalone, D. W., Marks, G. N., & Crepaz, N. (2006) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/01.qai.0000248342.05438.52 · Cited by 343 · cited 2×
“Two meta-analyses indicated that various behavioral strategies can be efficacious in promoting adherence and improving clinical outcomes.(7,8) Successful behavioral strategies include couples-based counseling(9); modified directly observed therapy(10); and cognitive-behavioral, problem-solving, and motivational interv…”
BackgroundSelf-citationSafren, S. A., W. Otto, M., Worth, J. L., Salomon, E., Johnson, W., Mayer, K., & Boswell, S. (2001) · Behaviour Research and Therapy · doi:10.1016/s0005-7967(00)00091-7 · Cited by 327 · cited 1×
“Successful behavioral strategies include couples-based counseling(9); modified directly observed therapy(10); and cognitive-behavioral, problem-solving, and motivational interviewing techniques.(11) Research on peer support and electronic reminders(12) is more limited, with mixed findings.”
BackgroundAddressing the Challenges of Adherence
Bartlett, J. A. (2002) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/00126334-200202011-00002 · Cited by 307 · cited 1×
“Consistent strict adherence remains key to successful viral suppression.(4) However, in both resource-rich and resource-constrained settings, the majority of patients on HAART struggle to maintain optimal levels of adherence.”
BackgroundAnalysis and Reporting of Factorial Trials
McAlister, F. A., Straus, S. E., Sackett, D. L., & Altman, D. G. (2003) · JAMA · doi:10.1001/jama.289.19.2545 · Cited by 287 · cited 1×
“This method maximizes the statistical power for detecting intervention effects when analyzing a factorial trial.(16) These power calculations indicated that 120 patients were”
Method
Cited by
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Interventions for enhancing medication adherence
Nieuwlaat, R., Wilczynski, N., Navarro, T., Hobson, N., Jeffery, R., Keepanasseril, A., Agoritsas, T., Mistry, N., Iorio, A., Jack, S., et al. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000011.pub4 · Cited by 2,945
Impact of HIV‐related stigma on treatment adherence: systematic review and meta‐synthesis
Katz, I. T., Ryu, A. E., Onuegbu, A. G., Psaros, C., Weiser, S. D., Bangsberg, D. R., & Tsai, A. C. (2013) · Journal of the International AIDS Society · doi:10.7448/ias.16.3.18640 · Cited by 1,126
“Likewise social support interventions should also be expected to improve adherence, but these have also proved inconclusive [200 203].”
ResultHealth behavior models in the age of mobile interventions: are our theories up to the task?
Riley, W. T., Rivera, D. E., Atienza, A. A., Nilsen, W., Allison, S. M., & Mermelstein, R. (2011) · Translational Behavioral Medicine · doi:10.1007/s13142-011-0021-7 · Cited by 978
Thompson, M., Mugavero, M. J., Amico, K. R., Cargill, V. A., Chang, L. W., Gross, R., Orrell, C., Altice, F. L., Bangsberg, D. R., Bartlett, J. G., et al. (2012) · Annals of Internal Medicine · doi:10.7326/0003-4819-156-11-201206050-00419 · Cited by 585
“…(high levels of substance use) 6 twice-monthly 60-min trained peerled support group with weekly telephone calls from peer for 3 wk X 6 mo Yes (T) No Simoni et al, 2009 (126) RCT in 224 HIV outpatient clinic patients in the U.S. Twice-monthly group and weekly telephone-based discussions with…”
Self-citationVervloet, M., Linn, A. J., van Weert, J. C. M., de Bakker, D. H., Bouvy, M. L., & van Dijk, L. (2012) · Journal of the American Medical Informatics Association · doi:10.1136/amiajnl-2011-000748 · Cited by 455
“The pager intervention revealing no effects delivered a minimum of three pager messages daily and a confirmation return page was requested for every message.(39)”
Background
Metadata
- Authors
- Simoni, J. M., Huh, D., Frick, P. A., Pearson, C. R., Andrasik, M. P., Dunbar, P. J., & Hooton, T. M.
- Affiliations
- University of Washington (US)
- University of Miami (US)
- Corresponding author
- Simoni, Jane M
- Huh, David
- Venue
- JAIDS Journal of Acquired Immune Deficiency Syndromes
- Published
- 2009-12
- Volume
- 52
- Issue
- 4
- Pages
- 465-473
- ISSN
- 1525-4135 (ISSN-L)
- PMC
- PMC2795576
- OpenAlex
- W2065765677
- Cited by
- 174
- References
- 21
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 5 · 2023: 6 · 2022: 12 · 2021: 5 · 2020: 10 · 2019: 7 · 2018: 14 · 2017: 12 · 2016: 15 · 2015: 17 · 2014: 7 · 2013: 20 · 2012: 15
- FWCI
- 8.85
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- JAIDS Journal of Acquired Immune Deficiency Syndromes (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH058986)
- National Institute of Allergy and Infectious Diseases (P30AI027757)
- Topics
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Health Professions › General Health Professions › Mobile Health and mHealth Applications
- Keywords
- peer support, antiretroviral therapy, medication adherence, HIV, highly active antiretroviral therapy, CD4 count, HIV-1 viral load, HIV outpatients, intervention efficacy
- MeSH terms
- Adult, Female, Humans, Male, Middle Aged, Patient Compliance, Peer Group, Social Support, HIV Infections, Anti-HIV Agents, Antiretroviral Therapy, Highly Active, Computers, Handheld, Young Adult
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