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Peer Support and Pager Messaging to Promote Antiretroviral Modifying Therapy in Seattle: A Randomized Controlled Trial
Open accessAbstract
OBJECTIVE: To determine the relative efficacy of peer support and pager messaging strategies versus usual care to improve medication adherence and clinical outcomes among HIV-positive outpatients initiating or switching to a new highly active antiretroviral therapy regimen. DESIGN: A 2 3 2 factorial randomized controlled trial of a 3-month intervention with computer-assisted self-interviews and blood draws administered at baseline, 3, 6, and 9 months. METHODS: HIV-positive patients at a public HIV specialty clinic in Seattle,WA (N = 224) were randomly assigned to peer support, pager messaging, both strategies, or usual care. The main outcomes were adherence according to self-report and electronic drug monitoring, CD4 count, and HIV-1 RNA viral load. RESULTS: Intent-to-treat analyses suggested the peer intervention was associated with greater self-reported adherence at immediate postintervention. However, these effects were not maintained at follow-up assessment; nor were there significant differences in biological outcomes. The pager intervention, on the other hand, was not associated with greater adherence but was associated with improved biological outcomes at postintervention that were sustained at follow-up. CONCLUSIONS: Analyses indicate the potential efficacy of peer support and pager messaging to promote antiretroviral adherence and biological outcomes, respectively. More potent strategies still are needed.
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“This intervention, however, failed to produce significant improvements in adherence over the 9-month trial relative to usual care or peer support”
From Health behavior models in the age of mobile interventions: are our theories up to the task? (2011) · cites this paper as [55]
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Longitudinal data analysis using generalized linear models
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“However, in both resource-rich and resource-constrained settings, the majority of patients on HAART struggle to maintain optimal levels of adherence.(5,6) Two meta-analyses indicated that various behavioral strategies can be efficacious in promoting adherence and improving clinical outcomes.”
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“A dichotomous variable for past week 100% adherence was created with participants classified as perfectly adherent if they missed zero doses and nonadherent if they missed 1 or more doses.(10,15) We computed a continuous EDM adherence variable, defined as the number of bottle openings recorded by the Medication Event…”
MethodSelf-citationThe Survival Benefits of AIDS Treatment in the United States
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“Two meta-analyses indicated that various behavioral strategies can be efficacious in promoting adherence and improving clinical outcomes.(7,8) Successful behavioral strategies include couples-based counseling(9); modified directly observed therapy(10); and cognitive-behavioral, problem-solving, and motivational interv…”
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BackgroundAddressing the Challenges of Adherence
Bartlett, J. A. (2002) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/00126334-200202011-00002 · Cited by 307 · cited 1×
“Consistent strict adherence remains key to successful viral suppression.(4) However, in both resource-rich and resource-constrained settings, the majority of patients on HAART struggle to maintain optimal levels of adherence.”
BackgroundAnalysis and Reporting of Factorial Trials
McAlister, F. A., Straus, S. E., Sackett, D. L., & Altman, D. G. (2003) · JAMA · doi:10.1001/jama.289.19.2545 · Cited by 287 · cited 1×
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Method
Cited by
Sorted by citations
Interventions for enhancing medication adherence
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Impact of HIV‐related stigma on treatment adherence: systematic review and meta‐synthesis
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“Likewise social support interventions should also be expected to improve adherence, but these have also proved inconclusive [200 203].”
ResultHealth behavior models in the age of mobile interventions: are our theories up to the task?
Riley, W. T., Rivera, D. E., Atienza, A. A., Nilsen, W., Allison, S. M., & Mermelstein, R. (2011) · Translational Behavioral Medicine · doi:10.1007/s13142-011-0021-7 · Cited by 978
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“…(high levels of substance use) 6 twice-monthly 60-min trained peerled support group with weekly telephone calls from peer for 3 wk X 6 mo Yes (T) No Simoni et al, 2009 (126) RCT in 224 HIV outpatient clinic patients in the U.S. Twice-monthly group and weekly telephone-based discussions with…”
Self-citationVervloet, M., Linn, A. J., van Weert, J. C. M., de Bakker, D. H., Bouvy, M. L., & van Dijk, L. (2012) · Journal of the American Medical Informatics Association · doi:10.1136/amiajnl-2011-000748 · Cited by 455
“The pager intervention revealing no effects delivered a minimum of three pager messages daily and a confirmation return page was requested for every message.(39)”
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“Seven (78%) interventions used cellular-mobile phones [38–43] and two used two-way alphanumeric pagers [44,45], with no statistically significant effect by device type observed (between groups Q = 0.”
for the ABC project team, Demonceau, J., Ruppar, T. M., Kristanto, P., Hughes, D. A., Fargher, E., Kardas, P., Geest, S. D., Dobbels, F., Lewek, P., et al. (2013) · Drugs · doi:10.1007/s40265-013-0041-3 · Cited by 321
“However, 5 [28–32] of the 79 studies were 3-arm or 4-arm studies testing the efficacy of more than one adherence-enhancing component, each compared with the same control group.”
BackgroundDepression Treatment Enhances Adherence to Antiretroviral Therapy: a Meta-Analysis
Sin, N. L., & DiMatteo, M. R. (2014) · Annals of Behavioral Medicine · doi:10.1007/s12160-013-9559-6 · Cited by 266
“For example, some studies considered a person adherent if he or she followed the prescribed treatment 100 % of the time [24–26], other studies defined adherence as following the prescribed treatment 95 % of the time [21, 23] or 90 % of the time [20, 27, 28], and others analyzed adherence as a continuous variable [22,…”
BackgroundPeer interventions to promote health: Conceptual considerations.
Simoni, J. M., Franks, J. C., Lehavot, K., & Yard, S. S. (2011) · American Journal of Orthopsychiatry · doi:10.1111/j.1939-0025.2011.01103.x · Cited by 266
“, 2008), HIV or AIDS (Simoni et al., 2009), and serious mental illness and addiction (Fors & Jarvis, 1995; Lawn et al.”
BackgroundInfluentialSelf-citationCelum, C., Delany‐Moretlwe, S., Baeten, J. M., van der Straten, A., Hosek, S., Bukusi, E. A., McConnell, M. A., Barnabas, R. V., & Bekker, L. (2019) · Journal of the International AIDS Society · doi:10.1002/jia2.25298 · Cited by 265
“Significantly higher effectiveness than efficacy was observed in open-label studies, including the PROUD study (immediate vs delayed open-label PrEP among men who have sex with men (MSM) attending sexual health clinics in the UK) [42] and HIV serodiscordant couples in the Partners Demo Project [43,44], which provided…”
BackgroundKanters, S., Park, J., Chan, K., Socias, M. E., Ford, N. P., Forrest, J. I., Thorlund, K., Nachega, J. B., & Mills, E. J. (2016) · The Lancet HIV · doi:10.1016/s2352-3018(16)30206-5 · Cited by 250
Interventions to improve adherence to antiretroviral therapy
Chaiyachati, K. H., Ogbuoji, O., Price, M., Suthar, A. B., Negussie, E. K., & Bärnighausen, T. (2014) · AIDS · doi:10.1097/qad.0000000000000252 · Cited by 235
Velloza, J., Khoza, N., Scorgie, F., Chitukuta, M., Mutero, P., Mutiti, K. S., Mangxilana, N. T., Nobula, L., Bulterys, M. A., Atujuna, M., et al. (2020) · Journal of the International AIDS Society · doi:10.1002/jia2.25463 · Cited by 225
“Social support interventions are likely key strategies to improve PrEP effectiveness among youth and in-person adherence clubs have been found to improve ART adherence among adolescents living with HIV [61].”
BackgroundThe effect of reminder systems on patients' adherence to treatment
West, C. E., Fenerty, Feldman, S. R., Kaplan, & Davis (2012) · Patient Preference and Adherence · doi:10.2147/ppa.s26314 · Cited by 201
Hardy, H., Kumar, V. S., Doros, G. D., Farmer, E. K., Drainoni, M., Rybin, D. V., Myung, D., Jackson, J., Backman, E. S., Stanic, A., et al. (2011) · AIDS Patient Care and STDs · doi:10.1089/apc.2010.0006 · Cited by 189
A systematic review of peer-supported interventions for health promotion and disease prevention
Ramchand, R., Ahluwalia, S. C., Xenakis, L., Apaydin, E., Raaen, L., & Grimm, G. (2017) · Preventive Medicine · doi:10.1016/j.ypmed.2017.06.008 · Cited by 183
“…et al (2010) Parallelgroup Exercise/Diet Women only; Minority racial/ethnic group Group Support TAU Physical health; Behavior; Mental health Simoni et al (2009) Parallelgroup Sexual behavior Adults Group Support; Individual Support TAU Physical Health; Behavior O'Grady et al…”
BackgroundThe role of prospective memory in medication adherence: a review of an emerging literature
Zogg, J. B., Woods, S. P., Sauceda, J. A., Wiebe, J. S., & Simoni, J. M. (2011) · Journal of Behavioral Medicine · doi:10.1007/s10865-011-9341-9 · Cited by 192
“Volmink and Garner (2007), Goggin et al. (2007) port for this approach comes from studies testing more generalized systems of peer-support in which investigators observed improvement in some measures of HIV medication adherence (Simoni et al., 2007, 2009).”
InfluentialSelf-citationGenberg, B. L., Shangani, S., Sabatino, K., Rachlis, B., Wachira, J., Braitstein, P. K. A., & Operario, D. (2016) · AIDS and Behavior · doi:10.1007/s10461-016-1307-z · Cited by 170
“…included studies (Chang et al. [13], Hatcher et al. [14], Kiweewa et al. [15], Richter et al. [16], Selke et al. [17]) were conducted in sub-Saharan Africa, with the remainder conducted in North America (Enriquez et al. [18], Purcell et al. [19], Simoni et al. 2009 [20], Simoni et al. 2007 [21]).”
BackgroundMethodAntiretroviral Adherence Interventions: Translating Research Findings to the Real World Clinic
Simoni, J. M., Amico, K. R., Smith, L. R., & Nelson, K. M. (2010) · Current HIV/AIDS Reports · doi:10.1007/s11904-009-0037-5 · Cited by 167
“As indicated in Table 1, successful interventions included adherence approaches incorporated into pharmacy usual care [12•], one-on-one and group-based peer support [19, 20]; peer-delivered modified directly observed therapy [21]; patient-centered or motivational interviewing-based approaches delivered by a nurse in p…”
MethodSelf-citationMacPherson, P., Munthali, C., Ferguson, J., Armstrong, A., Kranzer, K., Ferrand, R. A., & Ross, D. A. (2015) · Tropical Medicine & International Health · doi:10.1111/tmi.12517 · Cited by 164
Rethinking HIV prevention to prepare for oral PrEP implementation for young African women
Celum, C., Delany‐Moretlwe, S., McConnell, M. A., van Rooyen, H., Bekker, L., Kurth, A., Bukusi, E. A., Desmond, C., Morton, J. F., & Baeten, J. M. (2015) · Journal of the International AIDS Society · doi:10.7448/ias.18.4.20227 · Cited by 156
“Cognitive-behavioural approaches have been used to treat youth depression [106] and trauma [107], improve adult and youth ART adherence [104,105,108] and decrease alcohol use in HIV-infected subSaharan African adults [109].”
MethodResultKaplan, R. M., & Stone, A. A. (2013) · Annual Review of Psychology · doi:10.1146/annurev-psych-113011-143736 · Cited by 144
Easthall, C., Song, F., & Bhattacharya, D. (2013) · BMJ Open · doi:10.1136/bmjopen-2013-002749 · Cited by 113
Mbuagbaw, L., Sivaramalingam, B., Navarro, T., Hobson, N., Keepanasseril, A., Wilczynski, N. J., & Haynes, R. B. (2015) · AIDS Patients Care and STDs · doi:10.1089/apc.2014.0308 · Cited by 116
Chung, M. H., Richardson, B. A., Tapia, K., Benki-Nugent, S., Kiarie, J. N., Simoni, J. M., Overbaugh, J., Attwa, M., & John-Stewart, G. C. (2011) · PLoS Medicine · doi:10.1371/journal.pmed.1000422 · Cited by 109
Self-citationSocial Network Approaches to Recruitment, HIV Prevention, Medical Care, and Medication Adherence
Latkin, C. A., Davey-Rothwell, M. A., Knowlton, A. R., Alexander, K. A., Williams, C. T., & Boodram, B. (2013) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e3182928e2a · Cited by 108
Meta-analysis on the effect of text message reminders for HIV-related compliance
Mayer, J. E., & Fontelo, P. A. (2016) · AIDS Care · doi:10.1080/09540121.2016.1214674 · Cited by 109
Galárraga, O., Genberg, B. L., Martin, R. A., Laws, M. B., & Wilson, I. B. (2013) · AIDS and Behavior · doi:10.1007/s10461-013-0415-2 · Cited by 105
“The social environment has also been shown to bolster adherence [50–54] and in conditions of chronic poverty, patients adhered to ART in order to maintain family and friendship roles as sources of social capital [55].”
BackgroundTechnology-mediated interventions for enhancing medication adherence
Mistry, N., Keepanasseril, A., Wilczynski, N. L., Nieuwlaat, R., Ravall, M., Haynes, R. B., & the Patient Adherence Review Team (2015) · Journal of the American Medical Informatics Association · doi:10.1093/jamia/ocu047 · Cited by 102
“Simoni et al.(42) used a two-way pager messaging system that provided dosing reminders, education, adherence assessments, and entertainment, along with peer support, but did not find differences in adherence, viral load, or CD4 count.”
BackgroundInfluentialText Messaging Reduces HIV Risk Behaviors Among Methamphetamine-Using Men Who Have Sex with Men
Reback, C. J., Grant, D. L., Fletcher, J. B., Branson, C. M., SHOPTAW, S. J., Bowers, J. R., Charania, M. R., & Mansergh, G. (2012) · AIDS and Behavior · doi:10.1007/s10461-012-0200-7 · Cited by 97
“medication adherence [36–38], hepatitis vaccination [39], and bulimia nervosa [40].”
BackgroundSimoni, J. M., Wiebe, J. S., Sauceda, J. A., Huh, D., Sánchez, G., Longoria, V., Bedoya, C. A., & Safren, S. A. (2013) · AIDS and Behavior · doi:10.1007/s10461-013-0538-5 · Cited by 96
Self-citationCabral, H., Davis‐Plourde, K. L., Sarango, M., Fox, J. E., Palmisano, J. N., & Rajabiun, S. (2018) · AIDS and Behavior · doi:10.1007/s10461-017-1999-8 · Cited by 94
A Rapid Review of eHealth Interventions Addressing the Continuum of HIV Care (2007–2017)
Henny, K. D., Wilkes, A. L., McDonald, C. M., Denson, D. J., & Neumann, M. S. (2017) · AIDS and Behavior · doi:10.1007/s10461-017-1923-2 · Cited by 90
The Forms and Functions of Peer Social Support for People Living With HIV
Peterson, J. L., Rintamaki, L. S., Brashers, D. E., Goldsmith, D. J., & Neidig, J. L. (2011) · Journal of the Association of Nurses in AIDS Care · doi:10.1016/j.jana.2011.08.014 · Cited by 86
“Similar to the impact peer support can have on decision making, it can also have an impact on adherence (Simoni et al., 2009).”
BackgroundTao, D., Xie, L., Wang, T., & Wang, T. (2014) · Journal of Telemedicine and Telecare · doi:10.1177/1357633x14541041 · Cited by 87
“Intervention duration varied across trials, with a shortterm duration for 14 trials and a long-term duration for eight trials.(30,32,34,35,41,43) Based on our predetermined rules of outcome measure selection, patient adherence to medication was represented by the proportion of medication taken as prescribed in 15 tria…”
BackgroundResultInfluentialFishbein, J. N., Nisotel, L. E., MacDonald, J. J., Pensak, N. A., Jacobs, J. M., Flanagan, C. F., Jethwani, K., & Greer, J. A. (2017) · JMIR Research Protocols · doi:10.2196/resprot.6198 · Cited by 85
“Smartphones present an opportunity to implement more sophisticated EMIs and gather more detailed EMAs than prior research that has used short message service technology through pagers or non-Internet enabled cellular devices [14,15].”
Gilmore, H. J., Liu, A., Koester, K. A., Amico, K. R., McMahan, V., Goicochea, P., Vargas, L. S., Lubensky, D., Buchbinder, S., & Grant, R. M. (2013) · AIDS Patient Care and STDs · doi:10.1089/apc.2013.0116 · Cited by 83
“Future strategies to support MSM in discussing their participation in PrEP studies/implementation programs and their overall pill taking could include peer support interventions.(49) These interventions may include novel technology-based support strategies including SMS support groups,(50) or social media networking g…”
BackgroundManaged Problem Solving for Antiretroviral Therapy Adherence: A Randomized Trial
Gross, R., Bellamy, S. L., Chapman, J., Han, X.-Y., O’Duor, J., Palmer, S., Houts, P., Coyne, J., & Strom, B. (2013) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2013.2152 · Cited by 88
“Age, median (range), y 43 (20-65) 42 (19-60) Male sex 52 (57) 56 (63) Race Black 80 (88) 73 (82) White 9 (10) 15 (17) Other 2 (2) 1 (1) History of injection drug use 16 (18) 12 (14) Current drug use 21 (23) 27 (30) Hazardous alcohol use 14 (15) 18 (21) Unemployed 73 (85) 69 (78) Yearly income $5000 24 (28) 33 (36) Tre…”
Adherence to Antiretroviral Medications for HIV Pre-Exposure Prophylaxis
Koenig, L. J., Lyles, C. M., & Smith, D. K. (2012) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2012.09.047 · Cited by 82
Coomes, C. M., Lewis, M. A., Uhrig, J. D., Furberg, R., Harris, J. L., & Bann, C. (2011) · AIDS Care · doi:10.1080/09540121.2011.608421 · Cited by 70
“More recent studies using SMS have found some clinical improvement over time (Simoni et al., 2009) and a significant increase in adherence using self-report and other non-clinical measures (Hardy et al., 2011).”
BackgroundGwadz, M. V., Collins, L. M., Cleland, C. M., Leonard, N. R., Wilton, L., Gandhi, M., Braithwaite, R. S., Perlman, D. C., Kutnick, A. H., & Ritchie, A. S. (2017) · BMC Public Health · doi:10.1186/s12889-017-4279-7 · Cited by 76
Opportunities and Challenges of Digital Technology for HIV Treatment and Prevention
Simoni, J., Kutner, B. A., & Horvath, K. J. (2015) · Current HIV/AIDS Reports · doi:10.1007/s11904-015-0289-1 · Cited by 71
“Note there is a small number of more rigorously conducted studies showing efficacy for technology-delivered interventions, including significant effects on biomarker outcomes [6,7,14], encouraging further development in these areas.”
BackgroundSelf-citationRecent Advances (2011-2012) in Technology-Delivered Interventions for People Living with HIV
Pellowski, J. A., & Kalichman, S. C. (2012) · Current HIV/AIDS Reports · doi:10.1007/s11904-012-0133-9 · Cited by 66
“Technologies such as text messaging [13, 15, 16], pagers [18], cell phones [12], personal digital assistants (PDAs) [14], videophones [17], the internet [11, 21, 22], and computers [19, 20, 23–25] were commonly utilized.”
Psychosocial interventions enhance HIV medication adherence: A systematic review and meta-analysis
Spaan, P., van Luenen, S., Garnefski, N., & Kraaij, V. (2018) · Journal of Health Psychology · doi:10.1177/1359105318755545 · Cited by 69
Lehavot, K., Huh, D., Walters, K. L., King, K. M., Andrasik, M. P., & Simoni, J. M. (2011) · AIDS Patient Care and STDs · doi:10.1089/apc.2010.0314 · Cited by 66
Self-citationTechnology-Based Self-Care Methods of Improving Antiretroviral Adherence: A Systematic Review
Saberi, P., & Johnson, M. O. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027533 · Cited by 66
“Similarly, participants were randomized in another 2-by-2 factorial design to a peer-support intervention or a pager messaging strategy [50].”
BackgroundMethodResultInfluentialBouris, A. M., Jaffe, K., Eavou, R., Liao, C., Kuhns, L. M., Voisin, D. R., & Schneider, J. A. (2017) · AIDS and Behavior · doi:10.1007/s10461-017-1954-8 · Cited by 66
Horvath, K. J., Danilenko, G. P., Williams, M. L., Simoni, J., Amico, K., Oakes, J., & Rosser, B. R. S. (2012) · Aids and Behavior · doi:10.1007/s10461-012-0164-7 · Cited by 66
Self-citationRisher, K., Kapoor, S., Daramola, A. M., Paz‐Bailey, G., Skarbinski, J., Doyle, K., Shearer, K., Dowdy, D. W., Rosenberg, E. S., Sullivan, P. S., et al. (2017) · AIDS and Behavior · doi:10.1007/s10461-017-1687-8 · Cited by 62
Mathes, T., Pieper, D., Antoine, S., & Eikermann, M. (2013) · HIV Medicine · doi:10.1111/hiv.12051 · Cited by 63
Simoni, J. M., Chen, W., Huh, D., Fredriksen‐Goldsen, K. I., Pearson, C. R., Zhao, H., Shiu, C. A., Wang, X., & Zhang, F. (2010) · AIDS and Behavior · doi:10.1007/s10461-010-9828-3 · Cited by 62
“Research on electronic reminders is more mixed, with one recent study noting no improvement with the use of programmable twoway pagers to alert participants to dosing times [21].”
BackgroundSelf-citationHuang, D., Sangthong, R., McNeil, E., Chongsuvivatwong, V., Zheng, W., & Yang, X. (2013) · AIDS Research and Treatment · doi:10.1155/2013/580974 · Cited by 58
“Subsequently, a variety of electronic devices, such as pagers [31], disease management assistance system (DMAS) [32], electronic pill-cap [33], and alarms, have been used to regularly remind patients to take their medication [34].”
Use of peers to improve adherence to antiretroviral therapy: a global network meta‐analysis
Kanters, S., Park, J., Chan, K., Ford, N. P., Forrest, J. I., Thorlund, K., Nachega, J. B., & Mills, E. J. (2016) · Journal of the International AIDS Society · doi:10.7448/ias.19.1.21141 · Cited by 61
“[28] SOC 57 24 2003 Self-Report, 100% adherent B 1000 copies/ml at all three follow-up assessments No USA Healthy Treatment naı̈ve and experienced Adults”
Backgroundvan der Kop, M. L., Karanja, S., Thabane, L., Marra, C., Chung, M. H., Gelmon, L., Kimani, J., & Lester, R. T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046033 · Cited by 58
“[5,6,7,10,11] Research of patient characteristics associated with participant engagement in text-message interventions is limited.”
BackgroundResultCharania, M. R., Marshall, K. J., Lyles, C. M., Crepaz, N., Kay, L. S., Koenig, L. J., Weidle, P. J., & Purcell, D. W. (2013) · AIDS and Behavior · doi:10.1007/s10461-013-0594-x · Cited by 57
“sessions [41, 42, 46], two repetitive dosing interventions, defined as those in which sessions were implemented repeatedly without an explicit end point (both DAART; [40, 44]), and 5 EBIs with both discrete and repetitive dosing components [43, 45, 47, 48] (see Appendix A in supplementary material for detailed descrip…”
InfluentialBassett, I. V., Coleman, S. M., Giddy, J., Bogart, L. M., Chaisson, C. E., Ross, D., Wheatley, M. M., Robine, M., Govender, T., Freedberg, K. A., et al. (2016) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000001025 · Cited by 55
“Service delivery barrier 283 (29) 283 (31) 566 (30)”
Giordano, T. P., Cully, J. A., Amico, K. R., Davila, J. A., Kallen, M. A., Hartman, C. M., Wear, J., Buscher, A. L., & Stanley, M. A. (2016) · Clinical Infectious Diseases · doi:10.1093/cid/ciw322 · Cited by 53
Bere, T. C., Nyamayaro, P. C., Magidson, J. F., Chibanda, D., Chingono, A., Munjoma, R., Macpherson, K., Ndhlovu, C. E., O’Cleirigh, C. M., Kidia, K. K., et al. (2016) · Journal of Health Psychology · doi:10.1177/1359105315626783 · Cited by 49
“Life-Steps has been evaluated in resource-limited global contexts (Simoni et al., 2009, 2013), is potentially sustainable and scalable using a task-shifting approach (CDC, 2015; Papas et al., 2011) and has been used in international clinical trials in the AIDS Clinical Trials Group and the HIV…”
BackgroundMethodde Lima, I. C. V., Galvão, M., Alexandre, H. D. O., Lima, F. E. T., & de Araújo, T. L. (2016) · International Journal of Medical Informatics · doi:10.1016/j.ijmedinf.2016.04.013 · Cited by 15
Kekwaletswe, C., & Morojele, N. (2014) · Patient Preference and Adherence · doi:10.2147/ppa.s55547 · Cited by 47
Dutcher, M., Phicil, S., Goldenkranz, S. B., Rajabiun, S., Franks, J. C., Loscher-Hudson, B. S., & Mabachi, N. M. (2011) · AIDS Patient Care and STDs · doi:10.1089/apc.2010.0388 · Cited by 49
“Other research has stressed the importance of these types of peer support activities 7 as they provide both buffering effects (protecting individuals from responding harmfully to potentially stressful events) and mediating effects (influ-encing an individual’s self-efficacy) that positively impact…”
Simoni, J. M., Beima‐Sofie, K., Amico, K. R., Hosek, S., Johnson, M. O., & Mensch, B. (2019) · AIDS and Behavior · doi:10.1007/s10461-018-02387-3 · Cited by 46
Self-citationWang, Z., Zhu, Y., Cui, L., & Qu, B. (2019) · JMIR mhealth and uhealth · doi:10.2196/14404 · Cited by 48
“Studies were performed in the United States [50-52, 57, 59, The purpose of the included studies was to improve ART adherence of PLWH. Self-report (10/21) and electronic drug monitoring device (medication event monitoring system cap and EAMD [Wisepill]; 10/21) were the most commonly used methods to…”
InfluentialKnowlton, A. R., Yang, P., Bohnert, A. M., Wissow, L. S., Chander, G., & Arnsten, J. H. (2010) · AIDS and Behavior · doi:10.1007/s10461-010-9749-1 · Cited by 45
“Identifying aspects of existing supportive relationships associated with HAART adherence will inform potentially effective, low cost, and sustainable approaches to adherence intervention [3].”
BackgroundWebel, A. R., Phillips, J. C., Rose, C. D., Holzemer, W. L., Chen, W., Tyer‐Viola, L. A., Rivero‐Méndez, M., Nicholas, P. K., Nokes, K. M., Kemppainen, J. K., et al. (2012) · BMC Public Health · doi:10.1186/1471-2458-12-188 · Cited by 44
van der Kop, M. L., Ojakaa, D., Patel, A. R., Thabane, L., Kinagwi, K., Ekström, A., Smillie, K., Karanja, S., Awiti, P., Mills, E., et al. (2013) · BMJ Open · doi:10.1136/bmjopen-2013-003155 · Cited by 56
Graham, S. M., Micheni, M., Chirro, O., Nzioka, J., Secor, A., Mugo, P. M., Kombo, B. K., van der Elst, E., Operario, D., Amico, K. R., et al. (2020) · AIDS and Behavior · doi:10.1007/s10461-020-02786-5 · Cited by 44
Self-citationKim, S.-H., McDonald, S., Kim, S., Foster, C., & Fidler, S. (2015) · AIDS Patient Care and STDs · doi:10.1089/apc.2014.0335 · Cited by 42
“In adult populations, peer support groups have been shown to be an effective intervention to improve adherence to ART 25 and are recommended by the CDC as an evidence-based intervention.”
Operario, D., Smith, C. D., & Kegeles, S. M. (2008) · AIDS Education and Prevention · doi:10.1521/aeap.2008.20.4.347 · Cited by 42
Boucher, L. M., Liddy, C. E., Mihan, A., & Kendall, C. (2019) · AIDS and Behavior · doi:10.1007/s10461-019-02690-7 · Cited by 45
Stankievich, E., Foradori, I., Malanca, A., Ivalo, S., & Losso, M. H. (2015) · Journal of the International AIDS Society · doi:10.7448/ias.18.3.20132 · Cited by 41
Arnold, E. M., Swendeman, D. T., Harris, D., Fournier, J., Kozina, L., Abdalian, S., Rotheram‐Borus, M. J., & Adolescent Medicine Trials Network CARES Team (2018) · JMIR Research Protocols · doi:10.2196/10791 · Cited by 41
“Although peer support is a component of many evidence-based interventions, there are mixed findings in the meta-analyses conducted on peer support; some found a significant benefit [57,58] and others found a major benefit [59].”
Enriquez, M., & McKinsey (2011) · HIV/AIDS - Research and Palliative Care · doi:10.2147/hiv.s8993 · Cited by 41
Peers as Facilitators of Medication Adherence Interventions
Enriquez, M., & Conn, V. S. (2015) · Journal of Primary Care & Community Health · doi:10.1177/2150131915601794 · Cited by 40
Harris, L. T., Lehavot, K., Huh, D., Yard, S. S., Andrasik, M. P., Dunbar, P. J., & Simoni, J. M. (2010) · Telemedicine Journal and e-Health · doi:10.1089/tmj.2010.0050 · Cited by 40
Self-citationZullig, L. L., Deschodt, M., Liška, J., Bosworth, H. B., & Geest, S. D. (2018) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010818-021348 · Cited by 43
Shushtari, Z. J., Salimi, Y., Sajjadi, H., & Paykani, T. (2022) · AIDS and Behavior · doi:10.1007/s10461-022-03894-0 · Cited by 39
“…Tangible and informational support Not specified HIV specific support No • ProblemSolving Model • SelfDetermination Theory • Social Support Theory Simoni et al., 2009(25) HAART intervention A 3-month peer support intervention consisted of two parts: (1) “peer meetings”: six twicemonthly…”
Global Action to reduce HIV stigma and discrimination
Stangl, A. L., Grossman, C. I., Sidibé, M., Goosby, E., Grossman, C. I., Stangl, A. L., Katz, I. T., Ryu, A. E., Onuegbu, A., Psaros, C., et al. (2013) · Journal of the International AIDS Society · doi:10.7448/ias.16.3.18934 · Cited by 44
Graham, S. M., Micheni, M., Kombo, B. K., van der Elst, E. M., Mugo, P. M., Kivaya, E., Aunon, F. M., Kutner, B. A., Sanders, E. J., & Simoni, J. M. (2015) · AIDS · doi:10.1097/qad.0000000000000897 · Cited by 38
“For peer navigator training, we identified material from Project PAL [28,29], a peer support intervention, as a model that could be adapted for the Kenya MSM context.”
MethodSelf-citationMiller, C. W. T., & Himelhoch, S. (2013) · AIDS Research and Treatment · doi:10.1155/2013/670525 · Cited by 45
“, there was no improvement at any point of the intervention in terms of antiretroviral adherence when utilizing a two-way pager system (though there was improvement in biological markers of illness) [27].”
MethodStoner, S. A., Arenella, P. B., & Hendershot, C. S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0124613 · Cited by 37
“[20] found a medium effect size for a pager intervention compared to a peer support intervention (w = .”
Voisin, A. B. D. (2013) · Journal of AIDS & Clinical Research · doi:10.4172/2155-6113.1000236 · Cited by 39
“Such SCs are likely important not only for retention in care, but also for sustained health, risk reduction behavior maintenance and long-term adherence to antiretrovirals (ARVs) [28-30].”
BackgroundCully, J. A., Mignogna, J., Stanley, M. A., Davila, J. A., Wear, J., Amico, K. R., & Giordano, T. P. (2012) · AIDS Patient Care and STDs · doi:10.1089/apc.2011.0248 · Cited by 36
“Patient mentors may bring many qualities that can serve as catalysts for behavioral change for HIV patients not in regular HIV ambulatory care.(14) Patient mentors provide support, HIV-specific knowledge, and knowledge about how to effectively navigate the health care system.”
Chi, S. Y., Rabin, L. A., Aronov, A., Fogel, J., Kapoor, A., & Wang, C. (2014) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617714000964 · Cited by 42
“For example, using external prompts and detailed instructions simultaneously (Andrade et al., 2005; Martin-Saez, Deakins, Winson, Watson, & Wilson, 2011; Simoni et al., 2009; Wilson, Emslie, Quirk, & Evans, 2001) may be beneficial, compensating for both executive functioning and memory deficits.”
MethodAntiretroviral Therapy Adherence Support
Amico, K. R., & Orrell, C. (2013) · Journal of the International Association of Providers of AIDS Care (JIAPAC) · doi:10.1177/1545109712459041 · Cited by 34
King, E. M., Kinvig, K., Steif, J., Qiu, A. Q., Maan, E. J., Albert, A., Pick, N., Alimenti, A., Kestler, M., Money, D., et al. (2017) · Journal of Medical Internet Research · doi:10.2196/jmir.6631 · Cited by 33
“Several other SMS text-message interventions have been developed and implemented in HIV care with promising results; however, WelTel remains the approach validated in the largest setting to date [33-35].”
BackgroundFredriksen‐Goldsen, K. I., Shiu, C. A., Starks, H. E., Chen, W., Simoni, J. M., Kim, H., Pearson, C. R., Zhao, H., & Zhang, F. (2011) · AIDS Patient Care and STDs · doi:10.1089/apc.2010.0261 · Cited by 33
Self-citationCastel, A. D., Qasmieh, S. A., Greenberg, D., Ellenberger, N., Howell, T. H., Griffith, C. J., Wilbourn, B. C., Ganesan, K., Hussein, N. L., Ralte, G., et al. (2018) · JMIR Serious Games · doi:10.2196/10213 · Cited by 33
Marcellin, F., Spire, B., Carrieri, M., & Roux, P. (2013) · Expert Review of Anti-Infective Therapy · doi:10.1586/eri.13.8 · Cited by 34
“…counts, self-reports [36] Springer et al. (2009) Community setting and clinic, USA 127 6 months Virological suppression Self-reports [16] Simoni et al. (2009) Clinic, USA 224 9 months Adherence to ART Electronic monitoring, self-reports [17] Gross et al. (2009) Clinics, USA and South…”
Zhou, J., Sirisanthana, T., Kiertiburanakul, S., Chen, Y. A., Han, N., Lim, P., Kumarasamy, N., Choi, J. Y., Merati, T. P., Yunihastuti, E., et al. (2010) · BMC Infectious Diseases · doi:10.1186/1471-2334-10-361 · Cited by 32
Kirk, G. D., Linas, B. S., Westergaard, R. P., Piggott, D. A., Bollinger, R. C., Chang, L. W., & Genz, A. (2013) · AIDS Research and Treatment · doi:10.1155/2013/594671 · Cited by 29
“Text messages have been effectively utilized to improve attendance at clinic appointments, promote adherence to antiretroviral therapy (ART), and increase rates of viral suppression [7–14].”
BackgroundReflections on living with HIV over time: exploring the perspective of HIV-infected women over 50
Psaros, C., Barinas, J. L., Robbins, G. K., Bedoya, C. A., Park, E. R., & Safren, S. A. (2014) · Aging & Mental Health · doi:10.1080/13607863.2014.917608 · Cited by 30
“Peer-support interventions have been used with some success in PLWHA, including Fogarty et al. (2001), Simoni et al. (2009), and Safren et al. (2011).”
MethodHorvath, K. J., Amico, K. R., Erickson, D. J., Ecklund, A. M., Martinka, A., DeWitt, J., McLaughlin, J., & Parsons, J. T. (2018) · JMIR Research Protocols · doi:10.2196/10182 · Cited by 29
“Simoni and colleagues randomized 224 HIV-positive patients at a public HIV specialty clinic in Seattle, Washington to receive either in-person peer support, pager messaging, both in-person peer support and pager messaging, or usual care [22] for a 3-month period.”
BackgroundStoner, S. A., & Hendershot, C. S. (2012) · Addiction Science & Clinical Practice · doi:10.1186/1940-0640-7-9 · Cited by 29
Molton, J. S., Pang, Y., Wang, Z., Qiu, B., Wu, P., Rahman-Shepherd, A., Ooi, W. T., & Paton, N. I. (2016) · BMJ Open · doi:10.1136/bmjopen-2016-014194 · Cited by 29
“20 However, such systems can function as a reminder only and cannot provide a real-time assessment of adherence.”
BackgroundJohnson, L., Green, H. D., Koch, B., Stockman, J. K., Felsher, M. A., Roth, A. M., & Wagner, K. D. (2020) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000002571 · Cited by 28
Gaur, A. H., Belzer, M. E., Britto, P., Garvie, P. A., Hu, C., Graham, B., Neely, M. N., McSherry, G., Spector, S. A., & Flynn, P. M. (2010) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2010.0008 · Cited by 28
“In addition, our study results and the youth participant feedback underscore the need to develop community-based support for HIV-positive youth that is innovative and may utilize ‘‘nontraditional’’ support systems such as the church, 25 peers, 26 and accompagnateurs.”
Locher, C., Messerli, M., Gaab, J., & Gerger, H. (2019) · AIDS Patient Care and STDs · doi:10.1089/apc.2018.0164 · Cited by 28
Optimizing the Analysis of Adherence Interventions Using Logistic Generalized Estimating Equations
Huh, D., Flaherty, B. P., & Simoni, J. M. (2011) · AIDS and Behavior · doi:10.1007/s10461-011-9955-5 · Cited by 27
“peer and pager support treatments is detailed in a previous report [18].”
BackgroundMethodSelf-citationNetwork support, technology use, depression, and ART adherence among HIV-positive MSM of color
Holloway, I. W., Tan, D., Dunlap, S. L., Palmer, L., Beougher, S. C., & Cederbaum, J. A. (2017) · AIDS Care · doi:10.1080/09540121.2017.1325435 · Cited by 25
“While there is an understanding that social support can work to promote medication adherence among people living with HIV, interventions aimed at utilizing social networks to improve adherence have been mixed (Remien et al., 2005; Simoni et al., 2009; Simoni, Pantalone, Plummer, & Huang, 2007).”
Background
Metadata
- Authors
- Simoni, J. M., Huh, D., Frick, P. A., Pearson, C. R., Andrasik, M. P., Dunbar, P. J., & Hooton, T. M.
- Affiliations
- University of Washington (US)
- University of Miami (US)
- Corresponding author
- Simoni, Jane M
- Huh, David
- Venue
- JAIDS Journal of Acquired Immune Deficiency Syndromes
- Published
- 2009-12
- Volume
- 52
- Issue
- 4
- Pages
- 465-473
- ISSN
- 1525-4135 (ISSN-L)
- PMC
- PMC2795576
- OpenAlex
- W2065765677
- Cited by
- 174
- References
- 21
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 5 · 2023: 6 · 2022: 12 · 2021: 5 · 2020: 10 · 2019: 7 · 2018: 14 · 2017: 12 · 2016: 15 · 2015: 17 · 2014: 7 · 2013: 20 · 2012: 15
- FWCI
- 8.85
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- JAIDS Journal of Acquired Immune Deficiency Syndromes (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH058986)
- National Institute of Allergy and Infectious Diseases (P30AI027757)
- Topics
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Health Professions › General Health Professions › Mobile Health and mHealth Applications
- Keywords
- peer support, antiretroviral therapy, medication adherence, HIV, highly active antiretroviral therapy, CD4 count, HIV-1 viral load, HIV outpatients, intervention efficacy
- MeSH terms
- Adult, Female, Humans, Male, Middle Aged, Patient Compliance, Peer Group, Social Support, HIV Infections, Anti-HIV Agents, Antiretroviral Therapy, Highly Active, Computers, Handheld, Young Adult
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