The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
A Unified Theory of Sepsis-Induced Acute Kidney Injury: Inflammation, Microcirculatory Dysfunction, Bioenergetics, and the Tubular Cell Adaptation to Injury
Open accessAbstract
Given that the leading clinical conditions associated with acute kidney injury (AKI), namely, sepsis, major surgery, heart failure, and hypovolemia, are all associated with shock, it is tempting to attribute all AKI to ischemia on the basis of macrohemodynamic changes. However, an increasing body of evidence has suggested that in many patients, AKI can occur in the absence of overt signs of global renal hypoperfusion. Indeed, sepsis-induced AKI can occur in the setting of normal or even increased renal blood flow. Accordingly, renal injury may not be entirely explained solely on the basis of the classic paradigm of hypoperfusion, and thus other mechanisms must come into play. Herein, we put forward a "unifying theory" to explain the interplay between inflammation and oxidative stress, microvascular dysfunction, and the adaptive response of the tubular epithelial cell to the septic insult. We propose that this response is mostly adaptive in origin, that it is driven by mitochondria, and that it ultimately results in and explains the clinical phenotype of sepsis-induced AKI.
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Cites
Autophagy fights disease through cellular self-digestion
Mizushima, N., Levine, B., Cuervo, A. M., & Klionsky, D. J. (2008) · Nature · doi:10.1038/nature06639 · Cited by 6,452
Mitochondria and the Autophagy–Inflammation–Cell Death Axis in Organismal Aging
Green, D. R., Galluzzi, L., & Kroemer, G. (2011) · Science · doi:10.1126/science.1201940 · Cited by 1,245
Mitophagy is triggered by mild oxidative stress in a mitochondrial fission dependent manner
Frank, M., Duvezin-Caubet, S., Koob, S., Occhipinti, A., Jagasia, R., Petcherski, A., Ruonala, M. O., Priault, M., Salin, B., & Reichert, A. S. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.08.007 · Cited by 468
Augmenting Autophagy to Treat Acute Kidney Injury during Endotoxemia in Mice
Howell, G. M., Gomez, H., Collage, R. D., Loughran, P., Zhang, X., Escobar, D. A., Billiar, T. R., Zuckerbraun, B. S., & Rosengart, M. R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069520 · Cited by 105
Cited by
Ronco, C., Bellomo, R., & Kellum, J. A. (2019) · The Lancet · doi:10.1016/s0140-6736(19)32563-2 · Cited by 1,910
Self-citationCirrhosis-associated immune dysfunction: Distinctive features and clinical relevance
Albillos, A., Lario, M., & Álvarez-Mon, M. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.08.010 · Cited by 1,242
“…the oxidative stress that results from the organized interaction between PAMPs/ DAMPs and the tubular epithelial cell can hurt tubular function and cause acute kidney injury in patients with severe bacterial infection or even sepsis in the absence of overt signs of renal hypoperfusion [132,133].”
BackgroundBernardi, M., Moreau, R., Angeli, P., Schnabl, B., & Arroyo, V. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.07.004 · Cited by 632
Human serum albumin, systemic inflammation, and cirrhosis
Arroyo, V., García-Martinez, R., & Salvatella, X. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.04.012 · Cited by 560
Terlipressin plus Albumin for the Treatment of Type 1 Hepatorenal Syndrome
Wong, F., Pappas, S. C., Curry, M. P., Reddy, K. R., Rubin, R. A., Porayko, M. K., Gonzalez, S. A., Mumtaz, K., Lim, N., Simonetto, D. A., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2008290 · Cited by 482
Metadata
- Authors
- Gomez, H., Ince, C., De Backer, D., Pickkers, P., Payen, D., Hotchkiss, J., & Kellum, J. A.
- Venue
- Shock
- Published
- 2014-01
- Volume
- 41
- Issue
- 1
- Pages
- 3-11
- ISSN
- 1073-2322 (ISSN-L)
- OpenAlex
- W2000167232
- Cited by
- 783
- References
- 4
- FWCI
- 31.82
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: A Unified Theory of Sepsis-Induced Acute Kidney Injury: Inflammation, Microcirculatory Dysfunction, Bioenergetics, and the Tubular Cell Adaptation to Injury. https://app.cochat.ai/papers/10.1097/shk.0000000000000052
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- Gomez, H., Ince, C., De Backer, D., Pickkers, P., Payen, D., Hotchkiss, J., & Kellum, J. A. (2014). A Unified Theory of Sepsis-Induced Acute Kidney Injury: Inflammation, Microcirculatory Dysfunction, Bioenergetics, and the Tubular Cell Adaptation to Injury. Shock. https://doi.org/10.1097/shk.0000000000000052
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
