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CHARACTERIZATION OF THE INFLAMMATORY RESPONSE DURING ACUTE AND POST-ACUTE PHASES AFTER SEVERE BURN
Open accessAbstract
Severe burn causes a pronounced hypermetabolic response characterized by catabolism and extensive protein wasting. We recently found that this hypermetabolic state is driven by a severe inflammatory response. We characterized in detail the kinetics of serum levels of a panel of cytokines in a rat model, which may serve as reference for the development of therapeutic interventions applicable to humans. Male Sprague-Dawley rats (n = 8) received a full-thickness burn of 60% total body surface area. Serum was harvested 1, 3, 6, 12, 24, 48, 96, and 168 h after burn. Eight serum cytokines commonly used to assess the inflammatory response in humans, such as IL-1beta, IL-6, IL-10, TNF, vascular endothelial growth factor, and monocyte chemotactic protein 1, and the rat-specific cytokines cytokine-induced neutrophil chemoattractant (CINC) 1, CINC-2, and CINC-3 were measured by enzyme-linked immunosorbent assay technique and were compared with controls (n = 4). Statistical analysis was conducted using the t test, with P < 0.05 considered as significantly different. Thermal injury resulted in significantly increased serum levels of IL-1beta, IL-6, IL-10, monocyte chemotactic protein 1, CINC-1, CINC-2, and CINC-3 when compared with the concentrations detected in nonburned rats (P < 0.05). Serum levels of TNF-alpha and vascular endothelial growth factor in burned rats were not found to be significantly different to controls. Burn causes a profound inflammatory response in rats. Specific cytokines known to increase in humans postburn such as IL-1 beta, IL-6, IL-10, MCP-1, and IL-8 (CINC-1, CINC-2, and CINC-3 in the rat) were also observed in our rat burn model, which now allows us to study new anti-inflammatory treatment options.
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“The levels of MMP2 and 9 which are very important in reepithelization and tissue remodelling [31,32], are elevated very early on and reduced at later time points in the wound tissue of THS-expose mice suggesting its role in impaired wound closure.”
From Tobacco toxins deposited on surfaces (third hand smoke) impair wound healing (2016) · cites this paper as [31]
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Cites
Chemokines — Chemotactic Cytokines That Mediate Inflammation
Luster, A. D. (1998) · New England Journal of Medicine · doi:10.1056/nejm199802123380706 · Cited by 3,633
IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans
Steensberg, A., Fischer, C. P., Keller, C., Møller, K., & Pedersen, B. K. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00074.2003 · Cited by 1,135
Increased mortality associated with growth hormone treatment in critically ill adults
Takala, J., Ruokonen, E., Webster, N. R., Nielsen, M. S., Zandstra, D. F., Vundelinckx, G., & Hinds, C. J. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909093411102 · Cited by 1,023
INCREASED MORTALITY ASSOCIATED WITH GROWTH HORMONE TREATMENT IN CRITICALLY ILL ADULTS
Akala, J. U. T., Uokonen, E. S. R., Igel, N., Ebster, R. W., Ielsen, M. I. S. N., Andstra, D. U. F. Z., Undelinckx, G. U. V., & Inds, H. J. H. (1999) · Cited by 889
Response of Serum Interleukin-6 in Patients Undergoing Elective Surgery of Varying Severity
Cruickshank, A., Fraser, W. D., Burns, H. J. G., Damme, J. V., & Shenkin, A. (1990) · Clinical Science · doi:10.1042/cs0790161 · Cited by 746
Cytokine-mediated inflammation in acute lung injury
Goodman, R. B., Pugin, J., Lee, J. S., & Matthay, M. A. (2003) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(03)00059-5 · Cited by 684
Interleukin-6 in the Injured Patient
Biffl, W. L., Moore, E. E., Moore, F. A., & Peterson, V. M. (1996) · Annals of Surgery · doi:10.1097/00000658-199611000-00009 · Cited by 502
Interleukin‐6 Gene‐Deficient Mice Show Impaired Defense against Pneumococcal Pneumonia
van der Poll, T., Keogh, C. V., Guirao, X., Buurman, W. A., Köpf, M., & Lowry, S. F. (1997) · The Journal of Infectious Diseases · doi:10.1086/514062 · Cited by 382
Chemokines: signal lamps for trafficking of T and B cells for development and effector function
Kim, C. H., & Broxmeyer, H. E. (1999) · Journal of Leukocyte Biology · doi:10.1002/jlb.65.1.6 · Cited by 338
Interleukin-8 in sepsis: relation to shock and inflammatory mediators
Hack, C. E., Hart, M. H. L., van Schijndel, R. J. M. S., Eerenberg, A. J. M., Nuijens, J. H., THIJS, L. G., & Aarden, L. A. (1992) · Infection and Immunity · doi:10.1128/iai.60.7.2835-2842.1992 · Cited by 319
CYTOKINE EXPRESSION PROFILE OVER TIME IN SEVERELY BURNED PEDIATRIC PATIENTS
Finnerty, C. C., Herndon, D. N., Przkora, R., Pereira, C. T., Oliveira, H. M., Queiroz, D. M. M., Rocha, A. M. C., & Jeschke, M. G. (2006) · Shock · doi:10.1097/01.shk.0000223120.26394.7d · Cited by 297
Self-citationExperimental models of Gram-negative sepsis
Parker, S., & Watkins, P. E. (2001) · British journal of surgery · doi:10.1046/j.1365-2168.2001.01632.x · Cited by 233
Lyons, A., Kelly, J. L., Rodrick, M. L., Mannick, J. A., & Lederer, J. A. (1997) · Annals of Surgery · doi:10.1097/00000658-199710000-00006 · Cited by 211
Post burn muscle wasting and the effects of treatments
Pereira, C. T., Murphy, K. D., Jeschke, M. G., & Herndon, D. N. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2005.05.009 · Cited by 204
Self-citationIL-12 gene therapy protects mice in lethal Klebsiella pneumonia
Greenberger, M. J., Kunkel, S. L., Strieter, R. M., Lukacs, N. W., Bramson, J. L., Gauldie, J., Graham, F. L., Hitt, M., Danforth, J. M., & Standiford, T. J. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.7.3006 · Cited by 184
Herndon, D. N., Wilmore, D. W., & Mason, A. D. (1978) · Journal of Surgical Research · doi:10.1016/s0022-4804(78)80003-1 · Cited by 174
Self-citationden Berghe, G. V., de Zegher, F., Veldhuis, P. P., Wouters, P. J., Awouters, M., Verbruggen, W., Schetz, M., Verwaest, C., Lauwers, P., Bouillon, R., et al. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.2.3736 · Cited by 158
Frost, R. A., Lang, C. H., & Gelato, M. C. (1997) · Endocrinology · doi:10.1210/endo.138.10.5450 · Cited by 148
Cugini, D., Azzollini, N., Gagliardini, E., Cassis, P., Bertini, R., Colotta, F., Noris, M., Remuzzi, G., & Benigni, A. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.00272.x · Cited by 140
Insulin Attenuates the Systemic Inflammatory Response to Thermal Trauma
Jeschke, M. G., Einspanier, R., Klein, D., & Jauch, K. (2002) · Molecular Medicine · doi:10.1007/bf03402024 · Cited by 130
Self-citationRat CINC, a member of the interleukin-8 family, is a neutrophil-specific chemoattractant in vivo
Watanabe, K., Koizumi, F., Kurashige, Y., Tsurufuji, S., & NAKAGAWA, H. (1991) · Experimental and Molecular Pathology · doi:10.1016/0014-4800(91)90016-q · Cited by 129
CYTOKINE RESPONSE TO BURN INJURY
Bandt, J. P. D., Chollet‐Martin, S., Hernvann, A., Lioret, N., du Roure, L. D., Lim, S.-K., Vaubourdolle, M., Guechot, J., SAIZY, R., GIBOUDEAU, J., et al. (1994) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/00005373-199405000-00004 · Cited by 123
Body Composition Changes with Time in Pediatric Burn Patients
Przkora, R., Barrow, R. E., Jeschke, M. G., Suman-Vejas, O. E., Celis, M. M., Sanford, A. P., Chinkes, D. L., Mlcak, R. P., & Herndon, D. N. (2006) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/01.ta.0000214580.27501.19 · Cited by 115
Self-citationCatabolic response to stress and potential benefits of nutrition support
Wray, C. J., Mammen, J. M. V., & Hasselgren, P. (2002) · Nutrition · doi:10.1016/s0899-9007(02)00985-1 · Cited by 114
Monocyte chemotactic protein-1 and its role in insulin resistance
Sell, H., & Eckel, J. (2007) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3281338546 · Cited by 107
den Berghe, G. V. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.2.590 · Cited by 100
YAMADA, Y., Endo, S., & Inada, K. (1996) · Burns · doi:10.1016/s0305-4179(96)00052-6 · Cited by 97
Taniguchi, T., Koido, Y., Aiboshi, J., Yamashita, T., Suzaki, S., & Kurokawa, A. (1999) · The American Journal of Emergency Medicine · doi:10.1016/s0735-6757(99)90194-8 · Cited by 96
Vindenes, H. A., Ulvestad, E., & Bjerknes, R. (2002) · The European Journal of Surgery · doi:10.1080/110241598750005525 · Cited by 96
Schneider, C. P., Schwacha, M. G., & Chaudry, I. H. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.01.003 · Cited by 93
Marked increase in plasma interleukin-6 in burn patients.
Ueyama, M., Maruyama, I., Osame, M., & Sawada, Y. (1992) · PubMed · Cited by 82
Plasma tumour necrosis factor-α (TNF-α) levels in patients with burns
Endo, S., Inada, K., YAMADA, Y., Kasai, T., Takakuwa, T., Nakae, H., Kikuchi, M., Hoshi, S., Suzuki, M., Yamashita, H., et al. (1993) · Burns · doi:10.1016/0305-4179(93)90033-5 · Cited by 67
Yeh, F.-L., Shen, H., & Fang, R. (2002) · Burns · doi:10.1016/s0305-4179(02)00113-4 · Cited by 59
Li, X., Kovacs, E. J., Schwacha, M. G., Chaudry, I. H., & Choudhry, M. A. (2007) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00408.2006 · Cited by 56
Guillain‐Barré Syndrome: Multifactorial Mechanisms versus Defined Subgroups
van der Meché, F. G. A., Visser, L. H., Jacobs, B. C., Endtz, H. P., Meulstee, J., & van Doorn, P. A. (1997) · The Journal of Infectious Diseases · doi:10.1086/513779 · Cited by 56
Neutrophil migration induced by IL-8-activated mast cells is mediated by CINC-1
Ramos, C. (2003) · Cytokine · doi:10.1016/s1043-4666(03)00050-4 · Cited by 49
Infanger, M., Faramarzi, S., Grosse, J., Kurth, E., Ulbrich, C., Bauer, J. W., Wehland, M., Kreutz, R. H., Kossmehl, P. P., Paul, M., et al. (2007) · Cardiovascular Pathology · doi:10.1016/j.carpath.2007.04.001 · Cited by 38
NAKAGAWA, H., Ikesue, A., Hideko, K., DEBUCHI, H., Watanabe, K., Tsurufuji, S., NAGANAWA, M., & Mitamura, M. (1992) · Journal of Pharmacobio-Dynamics · doi:10.1248/bpb1978.15.461 · Cited by 35
Burn Injury and Pulmonary Sepsis: Development of a Clinically Relevant Model
Davis, K. A., Santaniello, J. M., He, L., Muthu, K., Sen, S., Jones, S. B., Gamelli, R. L., & Shankar, R. (2004) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/01.ta.0000108995.64133.90 · Cited by 33
Mitsuhashi, H., Hata, J., Asano, S., & Kishimoto, T. (1999) · Inflammation Research · doi:10.1007/s000110050508 · Cited by 33
The Early Acute Phase Response After Burn Injury in Mice
Plackett, T. P., Colantoni, A., Heinrich, S. A., Messingham, K. N., Gamelli, R. L., & Kovacs, E. J. (2007) · Journal of Burn Care & Research · doi:10.1097/bcr.0b013e31802cb84f · Cited by 29
Interleukin-1 and the response to injury
Kaplan, E., Dinarello, C. A., & Gelfand, J. A. (1989) · Immunologic Research · doi:10.1007/bf02919074 · Cited by 28
TUMOUR NECROSIS FACTOR: IMPLICATIONS FOR SURGICAL PATIENTS
Khalil, A. A., Hall, J. C., Aziz, F., & Price, P. (2006) · ANZ Journal of Surgery · doi:10.1111/j.1445-2197.2006.03921.x · Cited by 19
Change in location of cytokine-induced neutrophil chemoattractants (CINCs) in pulmonary silicosis
Hata, J., Aoki, K., Mitsuhashi, H., & Uno, H. (2003) · Experimental and Molecular Pathology · doi:10.1016/s0014-4800(03)00029-7 · Cited by 15
Modulation of Cytokine-Induced Production of IL-8 in Vitro by Interferons and Glucocorticosteroids
Nyhlén, K., Gautam, C., Andersson, R. G. G., & Uppugunduri, S. (2004) · Inflammation · doi:10.1023/b:ifla.0000033023.76110.51 · Cited by 15
Research works printed but not linked: 1
- Vindenes, 1995, Increased levels of circulating interleukin-8 in patients with large burns: relation to burn size and sepsis., JTrauma, 39, 635
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Jeschke, M. G., Kulp, G. A., Kraft, R., Finnerty, C. C., Mlcak, R. P., Lee, J. O., & Herndon, D. N. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201002-0190oc · Cited by 216
Self-citationThe Hepatic Response to Thermal Injury: Is the Liver Important for Postburn Outcomes?
Jeschke, M. G. (2009) · Molecular Medicine · doi:10.2119/molmed.2009.00005 · Cited by 173
Self-citationPathophysiological Response to Burn Injury in Adults
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Self-citationPathophysiologic Response to Burns in the Elderly
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Metadata
- Authors
- Gauglitz, G. G., Song, J., Herndon, D. N., Finnerty, C. C., Boehning, D., Barral, J. M., & Jeschke, M. G.
- Affiliations
- Shriners Hospitals for Children - Galveston (US)
- Shriners Hospitals for Children (US)
- The University of Texas Medical Branch at Galveston (US)
- Corresponding author
- Gauglitz, Gerd G.
- Song, Juquan
- Herndon, David N.
- Finnerty, Celeste C.
- Jeschke, Marc G.
- Venue
- Shock
- Published
- 2008-11
- Volume
- 30
- Issue
- 5
- Pages
- 503-507
- ISSN
- 1073-2322 (ISSN-L)
- PMC
- PMC7863568
- OpenAlex
- W1981192549
- Cited by
- 142
- References
- 46
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 3 · 2023: 7 · 2022: 12 · 2021: 6 · 2020: 10 · 2019: 7 · 2018: 6 · 2017: 8 · 2016: 5 · 2015: 12 · 2014: 9 · 2013: 4 · 2012: 8
- FWCI
- 8.44
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Shock (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (P50GM060338, R01 GM 56687, R01GM056687, P50 GM-60338, T32GM008256)
- Topics
- Health Sciences › Medicine › Surgery › Burn Injury Management and Outcomes
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Keywords
- severe burns, inflammation, cytokines, hypermetabolism, third-degree burns, IL-1β, interleukin-6, IL-10, MCP-1, CINC-1, TNF-α, vascular endothelial growth factor, rat burn model, anti-inflammatory therapy
- MeSH terms
- Animals, Burns, Enzyme-Linked Immunosorbent Assay, Inflammation, Interleukin-1, Male, Tumor Necrosis Factor-alpha, Interleukin-6, Interleukin-8, Interleukin-10, Rats, Sprague-Dawley, Chemokine CCL2, Chemokines, CXC, Vascular Endothelial Growth Factor A, Rats, Chemokine CXCL1
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