The DOI matches its Crossref record; 45 of the 46 references it cites were found in a registry or an index.
CHARACTERIZATION OF THE INFLAMMATORY RESPONSE DURING ACUTE AND POST-ACUTE PHASES AFTER SEVERE BURN
Open accessAbstract
Severe burn causes a pronounced hypermetabolic response characterized by catabolism and extensive protein wasting. We recently found that this hypermetabolic state is driven by a severe inflammatory response. We characterized in detail the kinetics of serum levels of a panel of cytokines in a rat model, which may serve as reference for the development of therapeutic interventions applicable to humans. Male Sprague-Dawley rats (n = 8) received a full-thickness burn of 60% total body surface area. Serum was harvested 1, 3, 6, 12, 24, 48, 96, and 168 h after burn. Eight serum cytokines commonly used to assess the inflammatory response in humans, such as IL-1beta, IL-6, IL-10, TNF, vascular endothelial growth factor, and monocyte chemotactic protein 1, and the rat-specific cytokines cytokine-induced neutrophil chemoattractant (CINC) 1, CINC-2, and CINC-3 were measured by enzyme-linked immunosorbent assay technique and were compared with controls (n = 4). Statistical analysis was conducted using the t test, with P < 0.05 considered as significantly different. Thermal injury resulted in significantly increased serum levels of IL-1beta, IL-6, IL-10, monocyte chemotactic protein 1, CINC-1, CINC-2, and CINC-3 when compared with the concentrations detected in nonburned rats (P < 0.05). Serum levels of TNF-alpha and vascular endothelial growth factor in burned rats were not found to be significantly different to controls. Burn causes a profound inflammatory response in rats. Specific cytokines known to increase in humans postburn such as IL-1 beta, IL-6, IL-10, MCP-1, and IL-8 (CINC-1, CINC-2, and CINC-3 in the rat) were also observed in our rat burn model, which now allows us to study new anti-inflammatory treatment options.
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“The levels of MMP2 and 9 which are very important in reepithelization and tissue remodelling [31,32], are elevated very early on and reduced at later time points in the wound tissue of THS-expose mice suggesting its role in impaired wound closure.”
From Tobacco toxins deposited on surfaces (third hand smoke) impair wound healing (2016) · cites this paper as [31]
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Cites
Chemokines — Chemotactic Cytokines That Mediate Inflammation
Luster, A. D. (1998) · New England Journal of Medicine · doi:10.1056/nejm199802123380706 · Cited by 3,633
IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans
Steensberg, A., Fischer, C. P., Keller, C., Møller, K., & Pedersen, B. K. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00074.2003 · Cited by 1,135
Increased mortality associated with growth hormone treatment in critically ill adults
Takala, J., Ruokonen, E., Webster, N. R., Nielsen, M. S., Zandstra, D. F., Vundelinckx, G., & Hinds, C. J. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909093411102 · Cited by 1,023
INCREASED MORTALITY ASSOCIATED WITH GROWTH HORMONE TREATMENT IN CRITICALLY ILL ADULTS
Akala, J. U. T., Uokonen, E. S. R., Igel, N., Ebster, R. W., Ielsen, M. I. S. N., Andstra, D. U. F. Z., Undelinckx, G. U. V., & Inds, H. J. H. (1999) · Cited by 889
Response of Serum Interleukin-6 in Patients Undergoing Elective Surgery of Varying Severity
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Cytokine-mediated inflammation in acute lung injury
Goodman, R. B., Pugin, J., Lee, J. S., & Matthay, M. A. (2003) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(03)00059-5 · Cited by 684
Interleukin-6 in the Injured Patient
Biffl, W. L., Moore, E. E., Moore, F. A., & Peterson, V. M. (1996) · Annals of Surgery · doi:10.1097/00000658-199611000-00009 · Cited by 502
Interleukin‐6 Gene‐Deficient Mice Show Impaired Defense against Pneumococcal Pneumonia
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Chemokines: signal lamps for trafficking of T and B cells for development and effector function
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Interleukin-8 in sepsis: relation to shock and inflammatory mediators
Hack, C. E., Hart, M. H. L., van Schijndel, R. J. M. S., Eerenberg, A. J. M., Nuijens, J. H., THIJS, L. G., & Aarden, L. A. (1992) · Infection and Immunity · doi:10.1128/iai.60.7.2835-2842.1992 · Cited by 319
Research works printed but not linked: 1
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Intensive Insulin Therapy in Severely Burned Pediatric Patients: A Prospective Randomized Trial
Jeschke, M. G., Kulp, G. A., Kraft, R., Finnerty, C. C., Mlcak, R. P., Lee, J. O., & Herndon, D. N. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201002-0190oc · Cited by 216
Self-citationThe Hepatic Response to Thermal Injury: Is the Liver Important for Postburn Outcomes?
Jeschke, M. G. (2009) · Molecular Medicine · doi:10.2119/molmed.2009.00005 · Cited by 173
Self-citationPathophysiological Response to Burn Injury in Adults
Stanojcic, M., Abdullahi, A., Rehou, S., Parousis, A., & Jeschke, M. G. (2016) · Annals of Surgery · doi:10.1097/sla.0000000000002097 · Cited by 172
Self-citationPathophysiologic Response to Burns in the Elderly
Jeschke, M. G., Patsouris, D., Stanojcic, M., Abdullahi, A., Rehou, S., Pinto, R. L., Chen, P., Burnett, M., & Amini‐Nik, S. (2015) · EBioMedicine · doi:10.1016/j.ebiom.2015.07.040 · Cited by 157
Self-citationHealing Mechanisms in Cutaneous Wounds: Tipping the Balance
Singer, A. J. (2021) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2021.0114 · Cited by 133
Metadata
- Authors
- Gauglitz, G. G., Song, J., Herndon, D. N., Finnerty, C. C., Boehning, D., Barral, J. M., & Jeschke, M. G.
- Affiliations
- Shriners Hospitals for Children - Galveston (US)
- Shriners Hospitals for Children (US)
- The University of Texas Medical Branch at Galveston (US)
- Corresponding author
- Gauglitz, Gerd G.
- Song, Juquan
- Herndon, David N.
- Finnerty, Celeste C.
- Jeschke, Marc G.
- Venue
- Shock
- Published
- 2008-11
- Volume
- 30
- Issue
- 5
- Pages
- 503-507
- ISSN
- 1073-2322 (ISSN-L)
- PMC
- PMC7863568
- OpenAlex
- W1981192549
- Cited by
- 142
- References
- 46
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 3 · 2023: 7 · 2022: 12 · 2021: 6 · 2020: 10 · 2019: 7 · 2018: 6 · 2017: 8 · 2016: 5 · 2015: 12 · 2014: 9 · 2013: 4 · 2012: 8
- FWCI
- 8.44
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Shock (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (P50GM060338, R01 GM 56687, R01GM056687, P50 GM-60338, T32GM008256)
- Topics
- Health Sciences › Medicine › Surgery › Burn Injury Management and Outcomes
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Keywords
- severe burns, inflammation, cytokines, hypermetabolism, third-degree burns, IL-1β, interleukin-6, IL-10, MCP-1, CINC-1, TNF-α, vascular endothelial growth factor, rat burn model, anti-inflammatory therapy
- MeSH terms
- Animals, Burns, Enzyme-Linked Immunosorbent Assay, Inflammation, Interleukin-1, Male, Tumor Necrosis Factor-alpha, Interleukin-6, Interleukin-8, Interleukin-10, Rats, Sprague-Dawley, Chemokine CCL2, Chemokines, CXC, Vascular Endothelial Growth Factor A, Rats, Chemokine CXCL1
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