Cited by 127Inflammatory Biomarkers in Disease PrognosisPancreatic and Hepatic Oncology ResearchCancer, Stress, Anesthesia, and Immune Response

Neutrophil-to-lymphocyte ratio is a predictive marker for invasive malignancy in intraductal papillary mucinous neoplasms of the pancreas

Gemenetzis, Georgios, Bagante, Fabio, Griffin, James F., Rezaee, Neda, Javed, Ammar A., Manos, Lindsey L., Lennon, Anne M., Wood, Laura D. +9 more·2017·Annals of Surgery

Abstract

OBJECTIVE: To evaluate the correlation between neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) values, and the presence of invasive carcinoma in patients with intraductal papillary mucinous neoplasm (IPMN). BACKGROUND: NLR and (PLR) are inflammatory markers that have been associated with overall survival in patients with invasive malignancies, including pancreatic cancer. METHODS: We retrospectively reviewed 272 patients who underwent surgical resection for histologically confirmed IPMN from January 1997 to July 2015. NLR and PLR were calculated and coevaluated with additional demographic, clinical, and imaging data for possible correlation with IPMN-associated carcinoma in the form of a predictive nomogram. RESULTS: NLR and PLR were significantly elevated in patients with IPMN-associated invasive carcinoma (P < 0.001). In the multivariate analysis, NLR value higher than 4 (P < 0.001), IPMN cyst of size more than 3 cm (P < 0.001), presence of enhanced solid component (P = 0.014), main pancreatic duct dilatation of more than 5 mm (P < 0.001), and jaundice (P < 0.001) were statistically significant variables. The developed statistical model has a c-index of 0.895. Implementation of the statistically significant variables in a predictive nomogram provided a reliable point system for estimating the presence of IPMN-associated invasive carcinoma. CONCLUSIONS: NLR is an independent predictive marker for the presence of IPMN-associated invasive carcinoma. Further prospective studies are needed to assess the predictive ability of NLR and how it can be applied in the clinical setting.

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Crossref · 10.1097/sla.0000000000001988

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Authors
Gemenetzis, G., Bagante, F., Griffin, J. F., Rezaee, N., Javed, A. A., Manos, L. L., Lennon, A. M., Wood, L. D., Hruban, R. H., Zheng, L., Zaheer, A., Fishman, E. K., Ahuja, N., Cameron, J. L., Weiss, M. J., He, J., & Wolfgang, C. L.
Affiliations
  • Johns Hopkins University (US)
  • Johns Hopkins Medicine (US)
Corresponding author
  • Gemenetzis, Georgios
  • Bagante, Fabio
  • Griffin, James F.
  • Rezaee, Neda
  • Javed, Ammar A.
  • Manos, Lindsey L.
  • Ahuja, Nita
  • Cameron, John L.
  • Weiss, Matthew J.
  • He, Jin
  • Wolfgang, Christopher L.
Venue
Annals of Surgery
Published
2017-08
Volume
266
Issue
2
Pages
339-345
ISSN
0003-4932 (ISSN-L)
OpenAlex
W2491724132
Cited by
127
References
50
Citations by year
2026: 7 · 2025: 8 · 2024: 4 · 2023: 8 · 2022: 17 · 2021: 24 · 2020: 21 · 2019: 15 · 2018: 14 · 2017: 9
FWCI
6.82
Type
journal article
Language
en
Open access
closed
Locations
  • Annals of Surgery (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
  • Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
  • Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
Keywords
neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, intraductal papillary mucinous neoplasm, pancreatic cancer, inflammatory markers, predictive nomogram, pancreatic cysts, main pancreatic duct dilatation, jaundice
MeSH terms
Aged, Carcinoma, Papillary, Female, Humans, Lymphocytes, Male, Middle Aged, Neoplasm Invasiveness, Neutrophils, Pancreatic Neoplasms, Platelet Count, Retrospective Studies, Biomarkers, Tumor, Multivariate Analysis, Lymphocyte Count, Carcinoma, Pancreatic Ductal, Nomograms

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