The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Multimodal Patient Blood Management Program Based on a Three-pillar Strategy: A Systematic Review and Meta-analysis
Open accessAbstract
Objectives: To determine whether a multidisciplinary, multimodal Patient Blood Management (PBM) program for patients undergoing surgery is effective in reducing perioperative complication rate, and thereby is effective in improving clinical outcome. Background: PBM is a medical concept with the focus on a comprehensive anemia management, to minimize iatrogenic (unnecessary) blood loss, and to harness and optimize patient-specific physiological tolerance of anemia. Methods: A systematic review and meta-analysis was performed. Eligible studies had to address each of the 3 PBM pillars with at least 1 measure per pillar, for example, preoperative anemia management plus cell salvage plus rational transfusion strategy. The study protocol has been registered with PROSPERO (CRD42017079217). Results: Seventeen studies comprising 235,779 surgical patients were included in this meta-analysis (100,886 pre-PBM group and 134,893 PBM group). Implementation of PBM significantly reduced transfusion rates by 39% [risk ratio (RR) 0.61, 95% confidence interval (CI) 0.55–0.68, P < 0.00001], 0.43 red blood cell units per patient (mean difference −0.43, 95% CI −0.54 to −0.31, P < 0.00001), hospital length of stay (mean difference −0.45, 95% CI −0.65 to −0.25, P < 0,00001), total number of complications (RR 0.80, 95% CI 0.74–0.88, P <0.00001), and mortality rate (RR 0.89, 95% CI 0.80–0.98, P = 0.02). Conclusions: Overall, a comprehensive PBM program addressing all 3 PBM pillars is associated with reduced transfusion need of red blood cell units, lower complication and mortality rate, and thereby improving clinical outcome. Thus, this first meta-analysis investigating a multimodal approach should motivate all executives and health care providers to support further PBM activities.
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Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement
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A Multicenter, Randomized, Controlled Clinical Trial of Transfusion Requirements in Critical Care
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Transfusion Strategies for Acute Upper Gastrointestinal Bleeding
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Liberal or Restrictive Transfusion in High-Risk Patients after Hip Surgery
Carson, J. L., Terrin, M. L., Noveck, H., Sanders, D. W., Chaitman, B. R., Rhoads, G. G., Nemo, G., Dragert, K., Beaupre, L., Hildebrand, K., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1012452 · Cited by 1,328
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Tranexamic Acid in Patients Undergoing Coronary-Artery Surgery
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Cited by
Bollag, L., Lim, G., Sultan, P., Habib, A. S., Landau, R., Zakowski, M., Tiouririne, M., Bhambhani, S., & Carvalho, B. (2021) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000005257 · Cited by 378
Thompson, A., Fleischmann, K. E., Smilowitz, N. R., de las Fuentes, L., Mukherjee, D., Aggarwal, N. R., Ahmad, F. S., Allen, R. B., Altin, S. E., Auerbach, A., et al. (2024) · Circulation · doi:10.1161/cir.0000000000001285 · Cited by 365
The role of evidence-based algorithms for rotational thromboelastometry-guided bleeding management
Görlinger, K., Pérez-Ferrer, A., Dirkmann, D., Saner, F., Maegele, M., Calatayud, Á. A. P., & Kim, T.-Y. (2019) · Korean Journal of Anesthesiology · doi:10.4097/kja.19169 · Cited by 257
Rössler, J., Schoenrath, F., Seifert, B., Kaserer, A., Spahn, G. H., Falk, V., & Spahn, D. R. (2020) · British Journal of Anaesthesia · doi:10.1016/j.bja.2019.09.016 · Cited by 132
Matthaei, H., Klein, A., Branchi, V., Kalff, J. C., & Koscielny, A. (2019) · International Journal of Colorectal Disease · doi:10.1007/s00384-019-03388-x · Cited by 21
Metadata
- Authors
- Althoff, F. C., Neb, H., Herrmann, E., Trentino, K. M., Vernich, L., Füllenbach, C., Freedman, J., Waters, J. H., Farmer, S., Leahy, M. F., Zacharowski, K., Meybohm, P., & Choorapoikayil, S.
- Venue
- Annals of Surgery
- Published
- 2019-05
- Volume
- 269
- Issue
- 5
- Pages
- 794-804
- ISSN
- 0003-4932 (ISSN-L)
- 1528-1140
- OpenAlex
- W2901558208
- Cited by
- 316
- References
- 38
- FWCI
- 15.72
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Althoff, F. C., Neb, H., Herrmann, E., Trentino, K. M., Vernich, L., Füllenbach, C., Freedman, J., Waters, J. H., Farmer, S., Leahy, M. F., Zacharowski, K., Meybohm, P., & Choorapoikayil, S. (2019). Multimodal Patient Blood Management Program Based on a Three-pillar Strategy: A Systematic Review and Meta-analysis. Annals of Surgery. https://doi.org/10.1097/sla.0000000000003095
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
