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Cited by 168Abdominal vascular conditions and treatmentsOptical Imaging and Spectroscopy TechniquesAugmented Reality Applications

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

Enhanced-Reality Video Fluorescence: A Real-Time Assessment of Intestinal Viability

Diana, Michele, Noll, Eric, Diemunsch, Pierre, Dallemagne, Bernard, Benahmed, Malika A., Agnus, Vincent, Soler, Luc, Barry, Brian, Namer, Izzie Jacques, Demartines, Nicolas, Charles, Anne-Laure, Geny, Bernard, Marescaux, Jacques·2014·Annals of Surgery
DOI 10.1097/sla.0b013e31828d4ab3
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Abstract

OBJECTIVE: Our aim was to evaluate a fluorescence-based enhanced-reality system to assess intestinal viability in a laparoscopic mesenteric ischemia model. MATERIALS AND METHODS: A small bowel loop was exposed, and 3 to 4 mesenteric vessels were clipped in 6 pigs. Indocyanine green (ICG) was administered intravenously 15 minutes later. The bowel was illuminated with an incoherent light source laparoscope (D-light-P, KarlStorz). The ICG fluorescence signal was analyzed with Ad Hoc imaging software (VR-RENDER), which provides a digital perfusion cartography that was superimposed to the intraoperative laparoscopic image [augmented reality (AR) synthesis]. Five regions of interest (ROIs) were marked under AR guidance (1, 2a-2b, 3a-3b corresponding to the ischemic, marginal, and vascularized zones, respectively). One hour later, capillary blood samples were obtained by puncturing the bowel serosa at the identified ROIs and lactates were measured using the EDGE analyzer. A surgical biopsy of each intestinal ROI was sent for mitochondrial respiratory rate assessment and for metabolites quantification. RESULTS: Mean capillary lactate levels were 3.98 (SD = 1.91) versus 1.05 (SD = 0.46) versus 0.74 (SD = 0.34) mmol/L at ROI 1 versus 2a-2b (P = 0.0001) versus 3a-3b (P = 0.0001), respectively. Mean maximal mitochondrial respiratory rate was 104.4 (±21.58) pmolO2/second/mg at the ROI 1 versus 191.1 ± 14.48 (2b, P = 0.03) versus 180.4 ± 16.71 (3a, P = 0.02) versus 199.2 ± 25.21 (3b, P = 0.02). Alanine, choline, ethanolamine, glucose, lactate, myoinositol, phosphocholine, sylloinositol, and valine showed statistically significant different concentrations between ischemic and nonischemic segments. CONCLUSIONS: Fluorescence-based AR may effectively detect the boundary between the ischemic and the vascularized zones in this experimental model.

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Crossref · 10.1097/sla.0b013e31828d4ab3

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Metadata

Authors
Diana, M., Noll, E., Diemunsch, P., Dallemagne, B., Benahmed, M. A., Agnus, V., Soler, L., Barry, B., Namer, I. J., Demartines, N., Charles, A.-L., Geny, B., & Marescaux, J.
Affiliations
  • Institut de Recherche contre les Cancers de l’Appareil Digestif (FR)
  • Centre Hospitalier Universitaire Vaudois (CH)
  • Université de Strasbourg (FR)
Corresponding author
  • Dallemagne, Bernard
  • Agnus, Vincent
  • Soler, Luc
  • Barry, Brian
  • Marescaux, Jacques
ORCID
Venue
Annals of Surgery
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2014-04
Volume
259
Issue
4
Pages
700-707
ISSN
0003-4932 (ISSN-L)
DOI
10.1097/sla.0b013e31828d4ab3
OpenAlex
W2020670928
Cited by
168
References
26
Citations by year
2026: 3 · 2025: 7 · 2024: 7 · 2023: 8 · 2022: 18 · 2021: 19 · 2020: 21 · 2019: 14 · 2018: 21 · 2017: 9 · 2016: 10 · 2015: 16 · 2014: 11
FWCI
13.45
Type
journal article
Language
en
Open access
closed
Locations
  • Annals of Surgery (publishedVersion)
  • PubMed (publishedVersion)
  • IRIS (submittedVersion)
  • SERVAL (Université de Lausanne) (submittedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Abdominal vascular conditions and treatments
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
  • Physical Sciences › Computer Science › Computer Vision and Pattern Recognition › Augmented Reality Applications
Keywords
fluorescence imaging, indocyanine green, mesenteric ischemia, intestinal viability, augmented reality, laparoscopic surgery, capillary lactate, intestinal metabolites, porcine model
MeSH terms
Animals, Female, Fluorescent Dyes, Image Interpretation, Computer-Assisted, Indocyanine Green, Intestine, Small, Ischemia, Male, Mesenteric Arteries, Mesentery, Mitochondria, Magnetic Resonance Spectroscopy, Laparoscopy, Spectrometry, Fluorescence, Swine, Video Recording, Biomarkers, Lactic Acid, Metabolome

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