The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Fresh Frozen Plasma Is Independently Associated With a Higher Risk of Multiple Organ Failure and Acute Respiratory Distress Syndrome
Abstract
BACKGROUND: Blood transfusion is known to be an independent risk factor for mortality, multiple organ failure (MOF), acute respiratory distress syndrome (ARDS), and nosocomial infection after injury. Less is known about the independent risks associated with plasma-rich transfusion components including fresh frozen plasma (FFP), platelets (PLTS), and cryoprecipitate (CRYO) after injury. We hypothesized that plasma-rich transfusion components would be independently associated with a lower risk of mortality but result in a greater risk of morbid complications. METHODS: Data were obtained from a multicenter prospective cohort study evaluating clinical outcomes in bluntly injured adults with hemorrhagic shock. All patients required blood transfusion for enrollment. Patients with isolated traumatic brain injury and those not surviving beyond 48 hours were excluded. Cox proportional hazard regression models were used to estimate the outcome risks (per unit) associated with plasma-rich transfusion requirements during the initial 24 hours after injury after controlling for important confounders. RESULTS: For the entire study population (n = 1,175), 65%, 41%, and 28% of patients received FFP, PLTS and CRYO, respectively. There was no association with plasma-rich transfusion components and mortality or nosocomial infection. For every unit given, FFP was independently associated with a 2.1% and 2.5% increased risk of MOF and ARDS, respectively. CRYO was associated with a 4.4% decreased risk of MOF (per unit), and PLTS were not associated with any of the outcomes examined. When early deaths (within 48 hours) were included in the model, FFP was associated with a 2.9% decreased risk of mortality per unit transfused. CONCLUSIONS: In patients who survive their initial injury, FFP was independently associated with a greater risk of developing MOF and ARDS, whereas CRYO was associated with a lower risk of MOF. Further investigation into the mechanisms by which these plasma-rich component transfusions are associated with these effects are required.
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Cited by
Holcomb, J. B., Tilley, B. C., Baraniuk, S., Fox, E. E., Wade, C. E., Podbielski, J. M., del Junco, D. J., Brasel, K. J., Bulger, E. M., Callcut, R. A., et al. (2015) · JAMA · doi:10.1001/jama.2015.12 · Cited by 2,526
Management of severe perioperative bleeding: Guidelines from the European Society of Anaesthesiology
Kozek-Langenecker, S. A., Afshari, A., Albaladejo, P., Santullano, C. A. A., De Robertis, E., Filipescu, D. C., Fries, D., Görlinger, K., Haas, T., Imberger, G., et al. (2013) · European Journal of Anaesthesiology · doi:10.1097/eja.0b013e32835f4d5b · Cited by 909
Prehospital Plasma during Air Medical Transport in Trauma Patients at Risk for Hemorrhagic Shock
Sperry, J. L., Guyette, F. X., Brown, J. B., Yazer, M. H., Triulzi, D. J., Early-Young, B. J., Adams, P. W., Daley, B. J., Miller, R. S., Harbrecht, B. G., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1802345 · Cited by 909
Self-citationBolliger, D., Seeberger, M. D., & Tanaka, K. A. (2012) · Transfusion Medicine Reviews · doi:10.1016/j.tmrv.2011.07.005 · Cited by 397
Wang, S.-C., Shieh, J.-F., Chang, K.-Y., Chu, Y.-C., Liu, C.-S., Loong, C.-C., Chan, K.-H., Mandell, S., & Tsou, M.-Y. (2010) · Transplantation Proceedings · doi:10.1016/j.transproceed.2010.05.144 · Cited by 331
Metadata
- Authors
- Watson, G. A., Sperry, J. L., Rosengart, M. R., Minei, J. P., Harbrecht, B. G., Moore, E. E., Cuschieri, J., Maier, R. V., Billiar, T. R., & Peitzman, A. B.
- Venue
- Journal of Trauma: Injury, Infection & Critical Care
- Published
- 2009-08
- Volume
- 67
- Issue
- 2
- Pages
- 221-230
- ISSN
- 0022-5282 (ISSN-L)
- OpenAlex
- W2044046314
- Cited by
- 321
- References
- 43
- FWCI
- 20.55
- Type
- journal article
- Language
- en
- Open access
- closed
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- Watson, G. A., Sperry, J. L., Rosengart, M. R., Minei, J. P., Harbrecht, B. G., Moore, E. E., Cuschieri, J., Maier, R. V., Billiar, T. R., & Peitzman, A. B. (2009). Fresh Frozen Plasma Is Independently Associated With a Higher Risk of Multiple Organ Failure and Acute Respiratory Distress Syndrome. Journal of Trauma: Injury, Infection & Critical Care. https://doi.org/10.1097/ta.0b013e3181ad5957
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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