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Cited by 68Smoking Behavior and CessationTransplantation: Methods and OutcomesRenal Transplantation Outcomes and Treatments

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Correlates and Outcomes of Posttransplant Smoking in Solid Organ Transplant Recipients: A Systematic Literature Review and Meta-Analysis

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Duerinckx, Nathalie, Burkhalter, Hanna, Engberg, Sandra J., Kirsch, Monika, Klem, Mary-Lou, Sereika, Susan M., De Simone, Paolo, De Geest, Sabina, Dobbels, Fabienne·2016·Transplantation
DOI 10.1097/tp.0000000000001335
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Abstract

BACKGROUND: Despite smoking being an absolute or relative contraindication for transplantation, about 11% to 40% of all patients continue or resume smoking posttransplant. This systematic review with meta-analysis investigated the correlates and outcomes associated with smoking after solid organ transplantation. METHODS: We searched PubMed, EMBASE, CINAHL, and PsycINFO from inception until January 2016, using state-of-the art methodology. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were computed for correlates/outcomes investigated 5 times or more. RESULTS: Seventy-three studies (43 in kidney, 17 in heart, 12 in liver, 1 in lung transplantation) investigated 95 correlates and 24 outcomes, of which 6 correlates and 4 outcomes could be included in the meta-analysis. The odds of smoking posttransplant were 1.33 times higher in men (95% CI, 1.12-1.57). Older individuals were significantly less likely to smoke (OR, 0.48; 95% CI, 0.38-0.62), as were patients with a higher body mass index (OR, 0.68; 95% CI, 0.52-0.89). Hypertension (OR, 1.16; 95% CI, 0.77-1.75), diabetes mellitus (OR, 0.52; 95% CI, 0.15-1.78), and having a history of cardiovascular disease (OR, 0.92; 95% CI, 0.77-1.09) were not significant correlates. Posttransplant smokers had higher odds of newly developed posttransplant cardiovascular disease (OR, 1.41; 95% CI, 1.02-1.95), nonskin malignancies (OR, 2.58; 95% CI, 1.26-5.29), a shorter patient survival time (OR, 0.59; 95% CI, 0.44-0.79), and higher odds of mortality (OR, 1.74; 95% CI, 1.21-2.48). CONCLUSIONS: Posttransplant smoking is associated with poor outcomes. Our results might help clinicians to understand which patients are more likely to smoke posttransplant, guide interventional approaches, and provide recommendations for future research.

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  • Smoking has been associated with mortality, malignancies and cardiovascular disease after solid organ transplantation.

    “However, especially smoking has been associated with mortality, malignancies and cardiovascular disease after solid organ transplantation[48] and can objectively assessed by health care workers by monitoring blood or urine levels of cotinine.”

    From Adherence is associated with a favorable outcome after lung transplantation (2019) · cites this paper as [48]

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Metadata

Authors
Duerinckx, N., Burkhalter, H., Engberg, S. J., Kirsch, M., Klem, M.-L., Sereika, S. M., De Simone, P., De Geest, S., & Dobbels, F.
Affiliations
  • University of Pisa (IT)
  • Brocher Foundation (CH)
ORCID
Venue
Transplantation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2016-11
Volume
100
Issue
11
Pages
2252-2263
ISSN
0041-1337 (ISSN-L)
DOI
10.1097/tp.0000000000001335
OpenAlex
W2517163464
Cited by
68
References
1
Citations by year
2026: 5 · 2025: 7 · 2024: 7 · 2023: 2 · 2022: 8 · 2021: 4 · 2020: 7 · 2019: 8 · 2018: 16 · 2017: 4
FWCI
1.10
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • Transplantation (publishedVersion)
  • PubMed (publishedVersion)
  • edoc (University of Basel) (submittedVersion, other-oa)
  • CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
  • edoc (University of Basel) (submittedVersion)
Funders
  • Northwestern University
  • University of Missouri
  • Fondation Brocher
  • University of Pittsburgh
  • Universität Basel
  • University of Missouri-Kansas City
  • Universitätsspital Basel
  • KU Leuven
  • Universitair Medisch Centrum Groningen
  • Università di Pisa
  • Sociedade Beneficente Israelita Brasileira Albert Einstein
  • Feinberg School of Medicine
  • School of Nursing, University of Pittsburgh
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
  • Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
  • Health Sciences › Medicine › Transplantation › Renal Transplantation Outcomes and Treatments
Keywords
solid organ transplantation, kidney transplantation, heart transplantation, liver transplantation, lung transplantation, smoking cessation, cardiovascular disease, patient survival, mortality, risk factors, body mass index, sex differences, age differences, diabetes mellitus, hypertension, cardiovascular disease history, transplant outcomes, smoking cessation interventions, smoking cessation counseling, smoking cessation pharmacotherapy, smoking cessation support
MeSH terms
Adolescent, Adult, Aged, Aged, 80 and over, Cardiovascular Diseases, Female, Humans, Male, Middle Aged, Smoking, Body Mass Index, Organ Transplantation, Treatment Outcome, Young Adult

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