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Cited by 1,192Smoking Behavior and CessationDiabetes, Cardiovascular Risks, and LipoproteinsObesity, Physical Activity, Diet

Consequences of smoking for body weight, body fat distribution, and insulin resistance

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Chiolero, Arnaud, Faeh, David, Paccaud, Fred, Cornuz, Jacques·2008·The American Journal of Clinical Nutrition
DOI 10.1093/ajcn/87.4.801
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Abstract

Our aim was to critically evaluate the relations among smoking, body weight, body fat distribution, and insulin resistance as reported in the literature. In the short term, nicotine increases energy expenditure and could reduce appetite, which may explain why smokers tend to have lower body weight than do nonsmokers and why smoking cessation is frequently followed by weight gain. In contrast, heavy smokers tend to have greater body weight than do light smokers or nonsmokers, which likely reflects a clustering of risky behaviors (eg, low degree of physical activity, poor diet, and smoking) that is conducive to weight gain. Other factors, such as weight cycling, could also be involved. In addition, smoking increases insulin resistance and is associated with central fat accumulation. As a result, smoking increases the risk of metabolic syndrome and diabetes, and these factors increase risk of cardiovascular disease. In the context of the worldwide obesity epidemic and a high prevalence of smoking, the greater risk of (central) obesity and insulin resistance among smokers is a matter of major concern.

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Crossref · 10.1093/ajcn/87.4.801

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  • Nicotine increases energy expenditure by raising resting metabolic rate and promoting lipolysis, leading to increased fat metabolism and reduced body weight.

    “Nicotine increases energy expenditure by raising the resting metabolic rate and promoting lipolysis, the breakdown of fats. This leads to increased fat metabolism and a reduction in body weight [10].”

    From Smoking and its impact on eating behavior: A review (2026) · cites this paper as [10]

  • Smoking increases insulin resistance and is associated with central fat accumulation, resulting in an increased risk of metabolic syndrome and diabetes.

    “smoking increases insulin resistance and is associated with central fat accumulation, thus resulting in an increased risk of a metabolic syndrome and diabetes”

    From Effects of Smoking Cessation on Hormonal Levels in Men (2013) · cites this paper as Chiolero et al. 2008

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Authors
Chiolero, A., Faeh, D., Paccaud, F., & Cornuz, J.
Affiliations
Centre Hospitalier Universitaire Vaudois (CH)
ORCID
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
2008-04
Volume
87
Issue
4
Pages
801-809
ISSN
0002-9165 (ISSN-L)
DOI
10.1093/ajcn/87.4.801
OpenAlex
W1846289750
Cited by
1,192
References
10
Citations by year
2026: 34 · 2025: 63 · 2024: 57 · 2023: 56 · 2022: 57 · 2021: 59 · 2020: 81 · 2019: 67 · 2018: 71 · 2017: 133 · 2016: 85 · 2015: 87 · 2014: 76 · 2013: 58 · 2012: 68
FWCI
5.04
Type
journal article
Language
en
Open access
Licence
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
  • IRIS (submittedVersion)
  • SERVAL (Université de Lausanne) (submittedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
Keywords
smoking, body weight, body fat distribution, insulin resistance, nicotine, energy expenditure, appetite, smoking cessation, weight gain, weight cycling, abdominal obesity, metabolic syndrome, diabetes mellitus, cardiovascular disease, obesity
MeSH terms
Appetite Regulation, Body Composition, Body Weight, Cardiovascular Diseases, Dose-Response Relationship, Drug, Energy Metabolism, Humans, Insulin Resistance, Nicotine, Obesity, Risk Factors, Risk-Taking, Smoking, Body Fat Distribution

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