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KDIGO Clinical Practice Guideline on the Evaluation and Care of Living Kidney Donors

Open access
Lentine, Krista L., Kasiske, Bertram L., Levey, Andrew S., Adams, Patricia L., Alberú, Josefina, Bakr, Mohamed A., Gallon, Lorenzo, Garvey, Catherine A., Guleria, Sandeep, Li, Philip Kam-Tao, Segev, Dorry L., Taler, Sandra J., Tanabe, Kazunari, Wright, Linda, Zeier, Martin G., Cheung, Michael, Garg, Amit X.·2017·Transplantation

Abstract

The 2017 Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline on the Evaluation and Care of Living Kidney Donors is intended to assist medical professionals who evaluate living kidney donor candidates and provide care before, during and after donation. The guideline development process followed the Grades of Recommendation Assessment, Development, and Evaluation (GRADE) approach and guideline recommendations are based on systematic reviews of relevant studies that included critical appraisal of the quality of the evidence and the strength of recommendations. However, many recommendations, for which there was no evidence or no systematic search for evidence was undertaken by the Evidence Review Team, were issued as ungraded expert opinion recommendations. The guideline work group concluded that a comprehensive approach to risk assessment should replace decisions based on assessments of single risk factors in isolation. Original data analyses were undertaken to produce a "proof-in-concept" risk-prediction model for kidney failure to support a framework for quantitative risk assessment in the donor candidate evaluation and defensible shared decision making. This framework is grounded in the simultaneous consideration of each candidate's profile of demographic and health characteristics. The processes and framework for the donor candidate evaluation are presented, along with recommendations for optimal care before, during, and after donation. Limitations of the evidence are discussed, especially regarding the lack of definitive prospective studies and clinical outcome trials. Suggestions for future research, including the need for continued refinement of long-term risk prediction and novel approaches to estimating donation-attributable risks, are also provided.In citing this document, the following format should be used: Kidney Disease: Improving Global Outcomes (KDIGO) Living Kidney Donor Work Group. KDIGO Clinical Practice Guideline on the Evaluation and Care of Living Kidney Donors. Transplantation. 2017;101(Suppl 8S):S1-S109.

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Metadata

Authors
Lentine, K. L., Kasiske, B. L., Levey, A. S., Adams, P. L., Alberú, J., Bakr, M. A., Gallon, L., Garvey, C. A., Guleria, S., Li, P. K.-T., Segev, D. L., Taler, S. J., Tanabe, K., Wright, L., Zeier, M. G., Cheung, M., & Garg, A. X.
Venue
Transplantation
Published
2017-08
Volume
101
Issue
8S
Pages
S7-S105
ISSN
0041-1337 (ISSN-L)
OpenAlex
W2739262366
Cited by
582
References
18
FWCI
50.90
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: KDIGO Clinical Practice Guideline on the Evaluation and Care of Living Kidney Donors. https://app.cochat.ai/papers/10.1097/tp.0000000000001769
The paper
Lentine, K. L., Kasiske, B. L., Levey, A. S., Adams, P. L., Alberú, J., Bakr, M. A., Gallon, L., Garvey, C. A., Guleria, S., Li, P. K.-T., Segev, D. L., Taler, S. J., Tanabe, K., Wright, L., Zeier, M. G., Cheung, M., & Garg, A. X. (2017). KDIGO Clinical Practice Guideline on the Evaluation and Care of Living Kidney Donors. Transplantation. https://doi.org/10.1097/tp.0000000000001769

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.