Reduced progression of diabetic microvascular complications with islet cell transplantation compared with intensive medical therapy
Abstract
Background The effect of islet cell transplantation (ICT) on the progression of diabetic microvascular complications is not well understood. Methods We have conducted a prospective, crossover, cohort study comparing ICT with intensive medical therapy on the progression of diabetic nephropathy, retinopathy, and neuropathy. Results The rate of decline in glomerular filtration rate is slower after ICT than on medical therapy. There was significantly more progression of retinopathy in medically treated patients than post-ICT. There was a nonsignificant trend for improved nerve conduction velocity post-ICT. Conclusions ICT is associated with less progression of microvascular complications than intensive medical therapy. Multicenter, randomized trials are needed to further study the role of ICT in slowing the progression of diabetic complications.
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Both whole organ pancreas and pancreatic islet transplantation can effectively prevent hypoglycemia, restore normoglycemia, and possibly stabilize the progression of complications of type 1 diabetes.
“Both therapeutic options can effectively prevent hypoglycemia, restore normoglycemia, and possibly stabilize the progression of complications of type 1 diabetes (223-227).”
Cites
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Hypoglycemia in the Diabetes Control and Complications Trial
The Diabetes Control and Complications Trial Research Group (1997) · Diabetes · doi:10.2337/diab.46.2.271 · Cited by 746 · see citing works
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Holt, R. I. G., DeVries, J. H., Hess-Fischl, A., Hirsch, I. B., Kirkman, M. S., Klupa, T., Ludwig, B., Nørgaard, K., Pettus, J., Renard, E., et al. (2021) · Diabetes Care · doi:10.2337/dci21-0043 · Cited by 699 · see citing works
Update on Islet Transplantation
McCall, M., & James Shapiro, A. M. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a007823 · Cited by 226 · see citing works
Vantyghem, M.-C., Raverdy, V., Balavoine, A.-S., Defrance, F., Caiazzo, R., Arnalsteen, L., Gmyr, V., Hazzan, M., Noël, C., Kerr-Conte, J., et al. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2115 · Cited by 103 · see citing works
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Chetboun, M., Drumez, E., Ballou, C., Maanaoui, M., Payne, E., Barton, F., Kerr-Conte, J., Vantyghem, M.-C., Piemonti, L., Rickels, M. R., et al. (2023) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(23)00082-7 · Cited by 64 · see citing works
- Authors
- Thompson, D. M., Meloche, M., Ao, Z., Paty, B., Keown, P., Shapiro, R. J., Ho, S., Worsley, D., Fung, M., Meneilly, G., Begg, I., Al Mehthel, M., Kondi, J., Harris, C., Fensom, B., Kozak, S. E., Tong, S. O., Trinh, M., & Warnock, G. L.
- Affiliations
- University of British Columbia (CA)
- Corresponding author
- Thompson, David M.
- ORCID
- Venue
- Transplantation
- Published
- 2011-02-15
- Volume
- 91
- Issue
- 3
- Pages
- 373-378
- ISSN
- 0041-1337 (ISSN-L)
- OpenAlex
- W1988670871
- Cited by
- 213
- References
- 2
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 9 · 2023: 15 · 2022: 8 · 2021: 20 · 2020: 13 · 2019: 15 · 2018: 19 · 2017: 12 · 2016: 20 · 2015: 20 · 2014: 19 · 2013: 13 · 2012: 20
- FWCI
- 18.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Transplantation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Keywords
- islet transplantation, diabetic microvascular complications, diabetic nephropathy, diabetic retinopathy, diabetic neuropathy, intensive medical therapy, glomerular filtration rate decline, nerve conduction velocity, disease progression
- MeSH terms
- Adult, Diabetes Mellitus, Type 1, Diabetic Angiopathies, Diabetic Nephropathies, Diabetic Neuropathies, Diabetic Retinopathy, Female, Humans, Hypoglycemic Agents, Insulin, Male, Middle Aged, Prospective Studies, Cohort Studies, Incidence, Islets of Langerhans Transplantation, Treatment Outcome, Disease Progression, Cross-Over Studies, Microvessels
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