Update on Islet Transplantation

McCall, M.; James Shapiro, A. M.

doi:10.1101/cshperspect.a007823

Cited by 226Pancreatic function and diabetesDiabetes and associated disordersDiabetes Management and Research

Update on Islet Transplantation

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McCall, M., James Shapiro, A. M.·2012·Cold Spring Harbor Perspectives in Medicine

DOI 10.1101/cshperspect.a007823PMC PMC3385934

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Abstract

Clinical islet transplantation has progressed considerably over the past 12 years, and >750 patients with type 1 diabetes have received islet transplants internationally over this time. Many countries are beginning to accept the transition from research to accepted and funded clinical care, especially for patients with brittle control that cannot be stabilized by more conventional means. Major challenges remain, including the need for more than one donor, and the requirement for potent, chronic immunosuppression. Combining immunological tolerance both to allo- and autoantigens, and a limitless expandable source of stem cell- or xenograft-derived insulin-secreting cells represent remaining hurdles in moving this effective treatment to a potential cure for all those with type 1 or 2 diabetes.

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Primary islets often demonstrated progressive functional decline in the years following transplantation, necessitating patients to resume exogenous insulin injections over time.
“Furthermore, primary islets often demonstrated progressive functional decline in the years following transplantation, necessitating patients to resume exogenous insulin injections overtime.”
From Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes (2023) · cites this paper as [124]
Because of major cell loss during the immediate aftermath of transplantation, a high islet mass from multiple organ donors and several infusions was used in the clinic.
“Because of this major cell loss during the immediate aftermath of transplantation, a high islet mass from multiple organ donors and several infusions was used in the clinic.”
From Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes (2023) · cites this paper as [124]

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Huurman, V. A. L., Velthuis, J. H. L., Hilbrands, R., Tree, T. I. M., Gillard, P., van der Meer-Prins, P. M. W., Duinkerken, G., Pinkse, G. G. M., Keymeulen, B., Roelen, D. L., et al. (2008) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2008.02479.x · Cited by 75 · see citing works
Assessment of Cytotoxic Lymphocyte Gene Expression in the Peripheral Blood of Human Islet Allograft Recipients
Han, D., Xu, X., Baidal, D. A., Leith, J., Ricordi, C., Alejandro, R., & Kenyon, N. S. (2004) · Diabetes · doi:10.2337/diabetes.53.9.2281 · Cited by 66 · see citing works
Iodixanol-Controlled Density Gradient During Islet Purification Improves Recovery Rate in Human Islet Isolation
Noguchi, H., Ikemoto, T., Naziruddin, B., Jackson, A. M., Shimoda, M., Fujita, Y., Chujo, D., Takita, M., Kobayashi, N., Onaca, N. N., et al. (2009) · Transplantation · doi:10.1097/tp.0b013e3181a5515c · Cited by 66 · see citing works
Successful Clinical Islet Isolation Using a GMP-Manufactured Collagenase and Neutral Protease
Szot, G. L., Lee, M. R. F., Tavakol, M. M., Lang, J., Dekovic, F., Kerlan, R. K., Stock, P. G., & Posselt, A. M. (2009) · Transplantation · doi:10.1097/tp.0b013e3181b443ae · Cited by 63 · see citing works
Autoimmune Diabetes and the Circle of Tolerance
Rossini, A. A. (2004) · Diabetes · doi:10.2337/diabetes.53.2.267 · Cited by 62 · see citing works
MRI as a tool to monitor islet transplantation
Medarova, Z. O., & Moore, A. V. (2009) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.130 · Cited by 61 · see citing works
Liraglutide, a Long-Acting Human Glucagon-Like Peptide 1 Analog, Improves Glucose Homeostasis in Marginal Mass Islet Transplantation in Mice
Merani, S., Truong, W., Emamaullee, J. A., Toso, C., Knudsen, L. B., & Shapiro, A. M. J. (2008) · Endocrinology · doi:10.1210/en.2008-0501 · Cited by 61 · see citing works
Changing Pattern of Organ Donation at a Single Center: Are Potential Brain Dead Donors Being Lost to Donation After Cardiac Death?
Saidi, R. F., Bradley, J., Greer, D. M., Luskin, R. S., O’Connor, K., Delmonico, F. L., Kennealey, P. T., Pathan, F., Schuetz, C., Elias, N., et al. (2010) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2010.03215.x · Cited by 57 · see citing works
Comparison of Human Islet Isolation Outcomes Using a New Mammalian Tissue-Free Enzyme Versus Collagenase NB-1
O’Gorman, D., Kin, T., Imes, S., Pawlick, R. L., Senior, P. A., & Shapiro, A. M. J. (2010) · Transplantation · doi:10.1097/tp.0b013e3181e117ce · Cited by 55 · see citing works
Inhibition of pancreatic islet beta cell function by tumor necrosis factor is blocked by a soluble tumor necrosis factor receptor.
Farney, A. C., Xenos, E. S., Sutherland, D. E. R., Widmer, M. B., STEPHANIAN, E., Field, M. J., Kaufman, D. B., Stevens, R. B., Blazar, B. A., & Platt, J. L. (1993) · PubMed · Cited by 49 · see citing works
Autoimmunity after Islet-Cell Allotransplantation
The Worcester Human Islet Transplantation Group (2006) · New England Journal of Medicine · doi:10.1056/nejmc061530 · Cited by 48 · see citing works
Recurrence of autoimmunity in pancreas transplant patients: research update
Pugliese, A., Reijonen, H., Nepom, J., & Burke, G. W. (2011) · Diabetes Management · doi:10.2217/dmt.10.21 · Cited by 47 · see citing works
Anakinra for rheumatoid arthritis
Mertens, M. T., & Singh, J. A. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005121.pub2 · Cited by 47 · see citing works
International Trial of the Edmonton Protocol for Islet Transplantation
Pruett, T. L. (2007) · Yearbook of Surgery · doi:10.1016/s0090-3671(08)70079-x · Cited by 47 · see citing works
Anti-proinflammatory Effects of Iodixanol (OptiPrep)-Based Density Gradient Purification on Human Islet Preparations
Mita, A., Ricordi, C., Messinger, S., Miki, A., Misawa, R., Barker, S., Molano, R., Haertter, R., Khan, A., Miyagawa, S., et al. (2010) · Cell Transplantation · doi:10.3727/096368910x516600 · Cited by 44 · see citing works
Large-Scale Comparison of Liberase HI and Collagenase NB1 Utilized for Human Islet Isolation
Brandhorst, H., Friberg, A., Nilsson, B., Andersson, H. H., Felldin, M., Foss, A., Salmela, K., Tibell, A., Tufveson, G., Korsgren, O., et al. (2010) · Cell Transplantation · doi:10.3727/096368909x477507 · Cited by 40 · see citing works
The caspase inhibitor IDN-6556 (PF3491390) improves marginal mass engraftment after islet transplantation in mice
McCall, M., Toso, C., Emamaullee, J. A., Pawlick, R. L., Edgar, R. L., Davis, J., Maciver, A. M., Kin, T., Arch, R. H., & Shapiro, A. M. J. (2011) · Surgery · doi:10.1016/j.surg.2011.02.023 · Cited by 39 · see citing works
Self-citation
Costimulation Blockade with Belatacept in Renal Transplantation
Dharnidharka, V. R. (2005) · New England Journal of Medicine · doi:10.1056/nejm200511103531919 · Cited by 35 · see citing works
ACUTE PORTAL HYPERTENSION AND DISSEMINATED INTRAVASCULAR COAGULATION FOLLOWING PANCREATIC ISLET AUTOTRANSPLANTATION AFTER SUBTOTAL PANCREATECTOMY
&NA; (1981) · Transplantation · doi:10.1097/00007890-198104000-00014 · Cited by 35 · see citing works
Resolution of Neurotoxicity and β-Cell Toxicity in an Islet Transplant Recipient following Substitution of Tacrolimus with MMF
Froud, T., Baidal, D. A., Ponte, G., Ferreira, J. V., Ricordi, C., & Alejandro, R. (2006) · Cell Transplantation · doi:10.3727/000000006783981639 · Cited by 34 · see citing works
TransEndoscopic Gastric SubMucosa Islet Transplantation (eGSM-ITx) in pigs with streptozotocine induced diabetes - technical aspects of the procedure - preliminary report.
Wszola, M., Berman, A., Fabisiak, M., Domagała, P., Zmudzka, M., Kieszek, R., Perkowska‐Ptasińska, A., Sabat, M., Pawelec, K., Kownacki, Ł., et al. (2009) · PubMed · Cited by 33 · see citing works
Elevation of Cytotoxic Lymphocyte Gene Expression Is Predictive of Islet Allograft Rejection in Nonhuman Primates
Han, D., Xu, X., Pastori, R. L., Ricordi, C., & Kenyon, N. S. (2002) · Diabetes · doi:10.2337/diabetes.51.3.562 · Cited by 33 · see citing works
Acute portal hypertension and disseminated intravascular coagulation following pancreatic islet autotransplantation after subtotal pancreatectomy.
Mittal, V. K., Toledo-Pereyra, L. H., Sharma, M., Ramaswamy, K., Puri, V., Cortez, J. A., & Gordon, D. (1981) · PubMed · Cited by 31 · see citing works
Chemical Immunosuppression in Islet Transplantation — Friend or Foe?
Chatenoud, L. (2008) · New England Journal of Medicine · doi:10.1056/nejmcibr0708067 · Cited by 26 · see citing works
Imaging the islet graft by positron emission tomography
Eriksson, O., & Alavi, A. (2012) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-011-1928-4 · Cited by 24 · see citing works
Detrimental effect of excessive collagenase class II on human islet isolation outcome
Kin, T., Zhai, X., O’Gorman, D., & Shapiro, A. M. J. (2008) · Transplant International · doi:10.1111/j.1432-2277.2008.00734.x · Cited by 23 · see citing works
CTLA-4Ig is Finally Making It: A Personal Perspective
Bluestone, J. A. (2005) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2005.00786.x · Cited by 22 · see citing works
Survival of pancreatic islet xenografts in NOD mice with the theracyte device.
Yang, Z., Chen, M., Fialkow, L. B., Ellett, J., Wu, R., & Nadler, J. L. (2002) · Transplantation Proceedings · doi:10.1016/s0041-1345(02)03685-0 · Cited by 19 · see citing works
Tetramer Analysis of Human Autoreactive CD4‐Positive T Cells
Nepom, G. T. (2005) · Advances in immunology · doi:10.1016/s0065-2776(05)88002-2 · Cited by 16 · see citing works
Diabetogenic Synergism in Canine Islet Autografts From Cyclosporine and Steroids in Combination
Shapiro, A. M. J., Hao, E., Lakey, J. R. T., Finegood, D. T., Rajotte, R. V., & Kneteman, N. M. (1998) · Transplantation Proceedings · doi:10.1016/s0041-1345(97)01390-0 · Cited by 14 · see citing works
Detrimental effect of prednisone on canine islet autograft function.
Morel, P., Kaufman, D. B., Field, M. J., Lloveras, J. K., Matas, A. J., & Sutherland, D. E. R. (1992) · PubMed · Cited by 14 · see citing works
Validation of the Scoring System for Standardization of the Pancreatic Donor for Islet Isolation as Used in a New Islet Isolation Center
Witkowski, P., Liu, Z., Cernea, S., Guo, Q., Poumian-Ruiz, E., Herold, K. C., & Hardy, M. A. (2006) · Transplantation Proceedings · doi:10.1016/j.transproceed.2006.08.143 · Cited by 11 · see citing works
THE STANDARDIZATION OF PANCREATIC DONORS FOR ISLET ISOLATIONS
O’Gorman, D., Richer, B., McGhee-Wilson, D., Shapiro, A. M. J., & Lakey, J. R. T. (2004) · Transplantation · doi:10.1097/00007890-200407271-00928 · Cited by 4 · see citing works

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Sorted by citations

Type 1 diabetes
Atkinson, M. A., Eisenbarth, G. S., & Michels, A. W. (2014) · The Lancet · doi:10.1016/s0140-6736(13)60591-7 · Cited by 2,713 · see citing works
Generation of Functional Human Pancreatic β Cells In Vitro
Pagliuca, F. W., Millman, J. R., Gürtler, M., Segel, M., Van Dervort, A., Ryu, J. H., Peterson, Q. P., Greiner, D., & Melton, D. A. (2014) · Cell · doi:10.1016/j.cell.2014.09.040 · Cited by 2,025 · see citing works
Acquisition of Dynamic Function in Human Stem Cell-Derived β Cells
Velazco-Cruz, L., Song, J., Maxwell, K. G., Goedegebuure, M. M., Augsornworawat, P., Hogrebe, N. J., & Millman, J. R. (2019) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.12.012 · Cited by 399 · see citing works
Transplantation of human islets without immunosuppression
Ludwig, B., Reichel, A., Steffen, A., Zimerman, B., Schally, A., Block, N., Colton, C., Ludwig, S., Kersting, S., Bonifacio, E., et al. (2013) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1317561110 · Cited by 265 · see citing works
Clinical imaging in regenerative medicine
Naumova, A. V., Modo, M., Moore, A. V., Murry, C. E., & Frank, J. A. (2014) · Nature Biotechnology · doi:10.1038/nbt.2993 · Cited by 244 · see citing works
Exosomes as new players in metabolic organ cross‐talk
Guay, C., & Regazzi, R. (2017) · Diabetes Obesity and Metabolism · doi:10.1111/dom.13027 · Cited by 244 · see citing works
Cell sheet approach for tissue engineering and regenerative medicine.
Matsuura, K., Utoh, R., Nagase, K., & Okano, T. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.05.024 · Cited by 225 · see citing works
Insulin-Producing Endocrine Cells Differentiated In Vitro From Human Embryonic Stem Cells Function in Macroencapsulation Devices In Vivo
Agulnick, A. D., Ambruzs, D. M., Moorman, M. A., Bhoumik, A., Cesario, R. M., Payne, J. K., Kelly, J. R., Haakmeester, C., Srijemac, R., Wilson, A. Z., et al. (2015) · Stem Cells Translational Medicine · doi:10.5966/sctm.2015-0079 · Cited by 248 · see citing works
Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes
Hogrebe, N. J., Ishahak, M., & Millman, J. R. (2023) · Cell Stem Cell · doi:10.1016/j.stem.2023.04.002 · Cited by 210 · see citing works
Long-Term Follow-Up of the Edmonton Protocol of Islet Transplantation in the United States
Brennan, D. C., Kopetskie, H. A., Sayre, P. H., Alejandro, R., Cagliero, E., Shapiro, A. M. J., Goldstein, J. S., DesMarais, M. R., Booher, S., & Bianchine, P. J. (2016) · American Journal of Transplantation · doi:10.1111/ajt.13458 · Cited by 176 · see citing works
“Similarly, the group from the University of Alberta recently reported sustained islet function as measured by the presence of C-peptide in 73% of their transplanted subjects, with 15% insulin independent at 9 years after transplantation (16).”
Self-citation
The journey of islet cell transplantation and future development
Gamble, A., Pepper, A. R., Bruni, A., & Shapiro, A. M. J. (2018) · Islets · doi:10.1080/19382014.2018.1428511 · Cited by 171 · see citing works
Self-citation
Engineering of magnetic nanoparticles as magnetic particle imaging tracers
Lu, C., Han, L., Wang, J., Wan, J., Song, G., & Rao, J. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00260g · Cited by 154 · see citing works
glucagon is essential for alpha cell transdifferentiation and beta cell neogenesis
Ye, L., Robertson, M. A., Hesselson, D., Stainier, D. Y. R., & Anderson, R. M. (2015) · Development · doi:10.1242/dev.117911 · Cited by 139 · see citing works
Clinical Efficacy of Stem Cell Therapy for Diabetes Mellitus: A Meta-Analysis
El-Badawy, A., & El‐Badri, N. (2016) · PLoS ONE · doi:10.1371/journal.pone.0151938 · Cited by 137 · see citing works
Inflammatory Response in Islet Transplantation
Kanak, M., Takita, M., Kunnathodi, F., Lawrence, M. C., Levy, M., & Naziruddin, B. (2014) · International Journal of Endocrinology · doi:10.1155/2014/451035 · Cited by 128 · see citing works
Modular tissue engineering for the vascularization of subcutaneously transplanted pancreatic islets
Vlahos, A. E., Cober, N., & Sefton, M. V. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1619216114 · Cited by 132 · see citing works
Therapies for Type 1 Diabetes: Current Scenario and Future Perspectives
Pathak, V., Pathak, N., O'Neill, C., Guduric-Fuchs, J., & Medina, R. (2019) · Clinical Medicine Insights: Endocrinology and Diabetes · doi:10.1177/1179551419844521 · Cited by 116 · see citing works
3D Bioprinting of Functional Islets of Langerhans in an Alginate/Methylcellulose Hydrogel Blend
Duin, S., Schütz, K., Ahlfeld, T., Lehmann, S., Lode, A., Ludwig, B., & Gelinsky, M. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201801631 · Cited by 113 · see citing works
The Efficacy of an Immunoisolating Membrane System for Islet Xenotransplantation in Minipigs
Neufeld, T., Ludwig, B., Barkai, U., Weir, G., Colton, C., Evron, Y., Balyura, M., Yavriyants, K., Zimermann, B., Azarov, D., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070150 · Cited by 110 · see citing works
Super-Resolution Imaging of ESCRT-Proteins at HIV-1 Assembly Sites
Prescher, J., Baumgärtel, V., Ivanchenko, S. V., Torrano, A. A., Bräuchle, C., Müller, B., & Lamb, D. C. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1004677 · Cited by 101 · see citing works
Economic 3D-printing approach for transplantation of human stem cell-derived β -like cells
Song, J., & Millman, J. R. (2016) · Biofabrication · doi:10.1088/1758-5090/9/1/015002 · Cited by 86 · see citing works
Improvement of islet engrafts by enhanced angiogenesis and microparticle-mediated oxygenation.
Montazeri, L., Hojjati-Emami, S., Bonakdar, S., Tahamtani, Y., Hajizadeh-Saffar, E., Noori-Keshtkar, M., Najar-Asl, M., Ashtiani, M. K., & Baharvand, H. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.02.043 · Cited by 73 · see citing works
FasL microgels induce immune acceptance of islet allografts in nonhuman primates
Lei, J., Coronel, M. M., Yolcu, E. S., Deng, H., Grimany-Nuno, O., Hunckler, M. D., Ulker, V., Yang, Z., Lee, K. M., Zhang, A., et al. (2022) · Science Advances · doi:10.1126/sciadv.abm9881 · Cited by 77 · see citing works
Clinical islet transplantation: is the future finally now?
Pepper, A. R., Bruni, A. D. C., & Shapiro, A. M. J. (2018) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0000000000000546 · Cited by 79 · see citing works
Animal Models of Diabetes Mellitus for Islet Transplantation
Sakata, N., Yoshimatsu, G., Tsuchiya, H., Egawa, S., & Unno, M. (2012) · Experimental Diabetes Research · doi:10.1155/2012/256707 · Cited by 72 · see citing works
A microfluidic device designed to induce media flow throughout pancreatic islets while limiting shear-induced damage
Silva, P. N., Green, B. J., Altamentova, S. M., & Rocheleau, J. V. (2013) · Lab on a Chip · doi:10.1039/c3lc50680k · Cited by 69 · see citing works
A Collagen Based Cryogel Bioscaffold that Generates Oxygen for Islet Transplantation
Razavi, M., Primavera, R., Kevadiya, B. D., Wang, J., Buchwald, P., & Thakor, A. S. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201902463 · Cited by 72 · see citing works
The Roles of Membrane Technology in Artificial Organs: Current Challenges and Perspectives
Nguyen, B. T. D., Thi, H. Y. N., Thi, B. P. N., Kang, D., & Kim, J. F. (2021) · Membranes · doi:10.3390/membranes11040239 · Cited by 70 · see citing works
Combined Pancreas-Kidney Transplantation for Patients With End-Stage Nephropathy Caused by Type-2 Diabetes Mellitus
Margreiter, C., Resch, T., Oberhuber, R., Aigner, F., Maier, H. T., Sucher, R., Schneeberger, S., Ulmer, H., Bösmüller, C., Margreiter, R., et al. (2013) · Transplantation · doi:10.1097/tp.0b013e3182861945 · Cited by 68 · see citing works
Magnetic particle imaging of islet transplantation in the liver and under the kidney capsule in mouse models.
Wang, P., Goodwill, P., Pandit, P., Gaudet, J., Ross, A. W., Wang, J., Yu, E. Y., Hensley, D., Doyle, T. C., Contag, C., et al. (2018) · Quantitative Imaging in Medicine and Surgery · doi:10.21037/qims.2018.02.06 · Cited by 59 · see citing works
Tissue Engineering Approaches to Cell-Based Type 1 Diabetes Therapy
Amer, L. D., Mahoney, M., & Bryant, S. (2014) · Tissue engineering. Part B, Reviews · doi:10.1089/ten.teb.2013.0462 · Cited by 68 · see citing works
GP2-enriched pancreatic progenitors give rise to functional beta cells in vivo and eliminate the risk of teratoma formation
Aghazadeh, Y., Sarangi, F., Poon, F., Nkennor, B., McGaugh, E. C., Nunes, S. S., & Nostro, M. C. (2022) · Stem Cell Reports · doi:10.1016/j.stemcr.2022.03.004 · Cited by 62 · see citing works
Cell based therapeutics in type 1 diabetes mellitus.
Zamboni, F., & Collins, M. (2017) · International journal of pharmaceutics · doi:10.1016/j.ijpharm.2017.02.063 · Cited by 49 · see citing works
Implantation underneath the abdominal anterior rectus sheath enables effective and functional engraftment of stem-cell-derived islets
Liang, Z., Sun, D., Lu, S., Lei, Z., Wang, S., Luo, Z., Zhan, J., Wu, S., Jiang, Y., Lu, Z., et al. (2023) · Nature Metabolism · doi:10.1038/s42255-022-00713-7 · Cited by 59 · see citing works
The Efficacy of a Prevascularized, Retrievable Poly(D,L,-lactide-co-ε-caprolactone) Subcutaneous Scaffold as Transplantation Site for Pancreatic Islets
Smink, A. M., Li, S., Hertsig, D. T., de Haan, B. J., Schwab, L. W., van Apeldoorn, A. A., de Koning, E. J. P., Faas, M. M., Lakey, J. R. T., & de Vos, P. (2017) · Transplantation · doi:10.1097/tp.0000000000001663 · Cited by 60 · see citing works
Effect of co-culture of mesenchymal stem/stromal cells with pancreatic islets on viability and function outcomes: a systematic review and meta-analysis
de Souza, B. D., Bouças, A. P., dos Santos, D. O. F., Reis, K. P., Ziegelmann, P., Bauer, A., & Crispim, D. (2017) · Islets · doi:10.1080/19382014.2017.1286434 · Cited by 53 · see citing works
Pancreatic islet transplantation: current advances and challenges
Wang, Q., Huang, Y.-X., Liu, L., Zhao, X.-H., Sun, Y., Mao, X.-L., & Li, S.-W. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1391504 · Cited by 63 · see citing works
Bisphenol A enhances kisspeptin neurons in anteroventral periventricular nucleus of female mice.
Wang, X.-L., Chang, F., Bai, Y., Chen, F., Zhang, J., & Chen, L. (2014) · Journal of Endocrinology · doi:10.1530/joe-13-0475 · Cited by 55 · see citing works
Hope vs hype: where are we in type 1 diabetes?
Skyler, J. S. (2018) · Diabetologia · doi:10.1007/s00125-017-4530-x · Cited by 51 · see citing works
Retrievable hydrogels for ovarian follicle transplantation and oocyte collection
Rios, P., Kniazeva, E., Lee, H. C., Xiao, S., Oakes, R. S., Saito, E., Jeruss, J. S., Shikanov, A., Woodruff, T. K., & Shea, L. D. (2018) · Biotechnology and Bioengineering · doi:10.1002/bit.26721 · Cited by 55 · see citing works
Long-Term Function of Alginate-Encapsulated Islets
Köllmer, M., Appel, A. A., Somo, S. I., & Brey, E. M. (2015) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2015.0140 · Cited by 54 · see citing works
A comprehensive microbiological safety approach for agarose encapsulated porcine islets intended for clinical trials
Gazda, L. S., Collins, J. E., Lovatt, A., Holdcraft, R. W., Morin, M. J., Galbraith, D. N., Graham, M. L., Laramore, M. A., Maclean, C., Black, J., et al. (2016) · Xenotransplantation · doi:10.1111/xen.12277 · Cited by 54 · see citing works
Autologous Islet Transplantation With Remote Islet Isolation After Pancreas Resection for Chronic Pancreatitis
Tai, D. S., Shen, N., Szot, G. L., Posselt, A. M., Feduska, N. J., Habashy, A., Clerkin, B. M., Core, E., Busuttil, R. W., Hines, O. J., et al. (2014) · JAMA Surgery · doi:10.1001/jamasurg.2014.932 · Cited by 52 · see citing works
Undifferentiated Wharton's Jelly Mesenchymal Stem Cell Transplantation Induces Insulin-Producing Cell Differentiation and Suppression of T-Cell-Mediated Autoimmunity in Nonobese Diabetic Mice
Tsai, P., Wang, H.-S., Lin, G., Chou, S., Chu, T.-H., Chuan, W.-T., Lu, Y.-J., Weng, Y.-J., Su, C., Hsieh, P., et al. (2014) · Cell Transplantation · doi:10.3727/096368914x683016 · Cited by 52 · see citing works
A hydrogel platform for in vitro three dimensional assembly of human stem cell-derived islet cells and endothelial cells
Augsornworawat, P., Velazco-Cruz, L., Song, J., & Millman, J. R. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.08.031 · Cited by 51 · see citing works
Islet Microencapsulation: Strategies and Clinical Status in Diabetes
Omami, M., McGarrigle, J. J., Reedy, M. B., Isa, D., Ghani, S., Marchese, E., Bochenek, M. A., Longi, M., Xing, Y., Joshi, I., et al. (2017) · Current Diabetes Reports · doi:10.1007/s11892-017-0877-0 · Cited by 48 · see citing works
Maturation of Stem Cell-Derived Beta-cells Guided by the Expression of Urocortin 3
van der Meulen, T., & Huising, M. O. (2014) · The Review of Diabetic Studies · doi:10.1900/rds.2014.11.115 · Cited by 45 · see citing works
Microvessel Network Formation and Interactions with Pancreatic Islets in Three-Dimensional Chip Cultures
Rambøl, M. H., Han, E. X., & Niklason, L. E. (2019) · Tissue Engineering Part A · doi:10.1089/ten.tea.2019.0186 · Cited by 45 · see citing works
The Fate of Allogeneic Pancreatic Islets following Intraportal Transplantation: Challenges and Solutions
Li, X., Meng, Q., & Zhang, L. (2018) · Journal of Immunology Research · doi:10.1155/2018/2424586 · Cited by 44 · see citing works
SIX2 Regulates Human β Cell Differentiation from Stem Cells and Functional Maturation In Vitro
Velazco-Cruz, L., Goedegebuure, M. M., Maxwell, K. G., Augsornworawat, P., Hogrebe, N. J., & Millman, J. R. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107687 · Cited by 44 · see citing works
Maintaining functional islets through encapsulation in an injectable saccharide–peptide hydrogel
Liao, S. W., Rawson, J., Omori, K., Ishiyama, K., Mozhdehi, D., Oancea, A. R., Ito, T., Guan, Z., & Mullen, Y. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.02.007 · Cited by 41 · see citing works
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Authors: McCall, M., & James Shapiro, A. M.
Affiliations: University of Alberta (CA)
ORCID: McCall, M.
Venue: Cold Spring Harbor Perspectives in Medicine
Publisher: Cold Spring Harbor Laboratory
Published: 2012-05-08
Volume: 2
Issue: 7
Pages: a007823-a007823
ISSN: 2157-1422 (ISSN-L)
DOI: 10.1101/cshperspect.a007823
PMC: PMC3385934
OpenAlex: W2111365775
Cited by: 226
References: 100
Citations by year: 2026: 1 · 2025: 9 · 2024: 9 · 2023: 10 · 2022: 12 · 2021: 20 · 2020: 14 · 2019: 26 · 2018: 19 · 2017: 18 · 2016: 16 · 2015: 22 · 2014: 28 · 2013: 18 · 2012: 4
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Cold Spring Harbor Perspectives in Medicine (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Diabetes Research Institute Foundation
Alberta Innovates - Health Solutions
Alberta Innovates
National Institutes of Health
National Institute of Allergy and Infectious Diseases
National Institute of Diabetes and Digestive and Kidney Diseases
National Center for Research Resources
Topics: Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords: islet transplantation, type 1 diabetes, type 2 diabetes, immune tolerance, immunosuppression, insulin-secreting cells, stem cell-derived islets, clinical translation
MeSH terms: Animals, Diabetes Mellitus, Type 1, Humans, Immunosuppression Therapy, Inflammation, Necrosis, Tissue and Organ Procurement, Portal System, Tumor Necrosis Factor-alpha, Autoimmunity, Islets of Langerhans Transplantation, Apoptosis

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