The DOI matches its Crossref record; 131 of the 134 references it cites were found in a registry or an index.
Blood−brain barrier breakdown and neovascularization processes after stroke and traumatic brain injury
Open accessAbstract
PURPOSE OF REVIEW: Angiogenesis or vascular reorganization plays a role in recovery after stroke and traumatic brain injury (TBI). In this review, we have focused on two major events that occur during stroke and TBI from a vascular perspective - what is the process and time course of blood-brain barrier (BBB) breakdown? and how does the surrounding vasculature recover and facilitate repair? RECENT FINDINGS: Despite differences in the primary injury, the BBB changes overlap between stroke and TBI. Disruption of BBB involves a series of events: formation of caveolae, trans and paracellular disruption, tight junction breakdown and vascular disruption. Confounding factors that need careful assessment and standardization are the severity, duration and extent of the stroke and TBI that influences BBB disruption. Vascular repair proceeds through long-term neovascularization processes: angiogenesis, arteriogenesis and vasculogenesis. Enhancing each of these processes may impart beneficial effects in endogenous recovery. SUMMARY: Our understanding of BBB breakdown acutely after the cerebrovascular injury has come a long way; however, we lack a clear understanding of the course of BBB disruption and BBB recovery and the evolution of individual cellular events associated with BBB change. Neovascularization responses have been widely studied in stroke for their role in functional recovery but the role of vascular reorganization after TBI in recovery is much less defined.
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“BBB dysfunction is a prominent pathological feature of both ischemic and hemorrhagic stroke and is typically associated with poor outcome (307, 312, 482).”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [482]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“In preclinical models of ischemic stroke, opening of BBB has been shown to be a biphasic phenomenon (482).”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [482]
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“For instance, it has been suggested that an increase of the blood-brain barrier (BBB) permeability could be determined by severe stress and/or traumatic brain injury [35,36].”
From C-Reactive protein as a biomarker for major depressive disorder? (2022) · cites this paper as [35]
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Cites
Heart Disease and Stroke Statistics—2015 Update: A Report From the American Heart Association
Mozaffarian, D., Benjamin, E. J., Go, A. S., Arnett, D. K., Blaha, M. J., Cushman, M., de Ferranti, S., Després, J.-P., Fullerton, H. J., Howard, V. J., et al. (2015) · Circulation · doi:10.1161/cir.0000000000000152 · Cited by 5,797
Angiogenesis in health and disease
Carmeliet, P. (2003) · Nature Medicine · doi:10.1038/nm0603-653 · Cited by 4,379
The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders
Zlokovic, B. V. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.003 · Cited by 3,280
Pericytes regulate the blood–brain barrier
Armulik, A., Genové, G., Mäe, M., Nisancioglu, M. H., Wallgard, E., Niaudet, C., He, L., Norlin, J., Lindblom, P., Strittmatter, K., et al. (2010) · Nature · doi:10.1038/nature09522 · Cited by 2,843
Development, maintenance and disruption of the blood-brain barrier
Obermeier, B., Daneman, R., & Ransohoff, R. M. (2013) · Nature Medicine · doi:10.1038/nm.3407 · Cited by 2,452
Ghajar, J. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02689-1 · Cited by 2,244
Pathophysiology of traumatic brain injury
Werner, C., & Engelhard, K. (2007) · British Journal of Anaesthesia · doi:10.1093/bja/aem131 · Cited by 1,712
Animal models of traumatic brain injury
Xiong, Y., Mahmood, A., & Chopp, M. (2013) · Nature reviews. Neuroscience · doi:10.1038/nrn3407 · Cited by 1,456
The New Neurometabolic Cascade of Concussion
Giza, C. C., & Hovda, D. A. (2014) · Neurosurgery · doi:10.1227/neu.0000000000000505 · Cited by 1,353
The Neurometabolic Cascade of Concussion.
Giza, C. C., & Hovda, D. A. (2001) · PubMed Central · Cited by 1,342
Cited by
Sorted by citations
Blood-Brain Barrier: From Physiology to Disease and Back
Sweeney, M. D., Zhao, Z., Montagne, A., Nelson, A. R., & Zlokovic, B. V. (2019) · Physiological Reviews · doi:10.1152/physrev.00050.2017 · Cited by 2,312
Blood-brain barrier dysfunction and recovery after ischemic stroke
Jiang, X., Andjelkovic, A. V., Zhu, L., Yang, T., Bennett, M. V. L., Chen, J., Keep, R. F., & Shi, Y. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.10.001 · Cited by 967
Organotypic vasculature: From descriptive heterogeneity to functional pathophysiology
Augustin, H. G., & Koh, G. Y. (2017) · Science · doi:10.1126/science.aal2379 · Cited by 790
Abdullahi, W., Tripathi, D. K., & Ronaldson, P. T. (2018) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00095.2018 · Cited by 623
“Such barrier breakdown leads to a significant increase in paracellular permeability at the level of the cerebral microvasculature, a remarkable pathological feature of stroke (68, 115).”
BackgroundChen, A., Fang, Z. H., Chen, X.-L., Yang, S., Zhou, Y., Mao, L., Xia, Y., Jin, H., Li, Y., You, M., et al. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1716-9 · Cited by 559
Metadata
- Authors
- Prakash, R., & Carmichael, S. T.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Prakash, Roshini
- Venue
- Current Opinion in Neurology
- Published
- 2015-12
- Volume
- 28
- Issue
- 6
- Pages
- 556-564
- ISSN
- 1350-7540 (ISSN-L)
- PMC
- PMC5267616
- OpenAlex
- W2341136898
- Cited by
- 296
- References
- 134
- Citations by year
- 2026: 16 · 2025: 27 · 2024: 32 · 2023: 29 · 2022: 33 · 2021: 38 · 2020: 36 · 2019: 31 · 2018: 24 · 2017: 19 · 2016: 11
- FWCI
- 1.44
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Neurology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS081055, R01NS053957)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
- Keywords
- blood-brain barrier disruption, neovascularization, stroke, traumatic brain injury, angiogenesis, arteriogenesis, vasculogenesis, vascular repair, caveolae, tight junction disruption, paracellular permeability, functional recovery
- MeSH terms
- Blood-Brain Barrier, Brain Injuries, Humans, Neovascularization, Physiologic, Stroke
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