Cited by 296Barrier Structure and Function StudiesTraumatic Brain Injury and Neurovascular DisturbancesAcute Ischemic Stroke Management

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Blood−brain barrier breakdown and neovascularization processes after stroke and traumatic brain injury

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Prakash, Roshini, Carmichael, S. Thomas·2015·Current Opinion in Neurology

DOI 10.1097/wco.0000000000000248PMC PMC5267616

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Abstract

PURPOSE OF REVIEW: Angiogenesis or vascular reorganization plays a role in recovery after stroke and traumatic brain injury (TBI). In this review, we have focused on two major events that occur during stroke and TBI from a vascular perspective - what is the process and time course of blood-brain barrier (BBB) breakdown? and how does the surrounding vasculature recover and facilitate repair? RECENT FINDINGS: Despite differences in the primary injury, the BBB changes overlap between stroke and TBI. Disruption of BBB involves a series of events: formation of caveolae, trans and paracellular disruption, tight junction breakdown and vascular disruption. Confounding factors that need careful assessment and standardization are the severity, duration and extent of the stroke and TBI that influences BBB disruption. Vascular repair proceeds through long-term neovascularization processes: angiogenesis, arteriogenesis and vasculogenesis. Enhancing each of these processes may impart beneficial effects in endogenous recovery. SUMMARY: Our understanding of BBB breakdown acutely after the cerebrovascular injury has come a long way; however, we lack a clear understanding of the course of BBB disruption and BBB recovery and the evolution of individual cellular events associated with BBB change. Neovascularization responses have been widely studied in stroke for their role in functional recovery but the role of vascular reorganization after TBI in recovery is much less defined.

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Authors: Prakash, R., & Carmichael, S. T.
Affiliations: University of California, Los Angeles (US)
Corresponding author: Prakash, Roshini
ORCID: Prakash, Roshini
Carmichael, S. Thomas
Venue: Current Opinion in Neurology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2015-12
Volume: 28
Issue: 6
Pages: 556-564
ISSN: 1350-7540 (ISSN-L)
DOI: 10.1097/wco.0000000000000248
PMC: PMC5267616
OpenAlex: W2341136898
Cited by: 296
References: 134
Citations by year: 2026: 16 · 2025: 27 · 2024: 32 · 2023: 29 · 2022: 33 · 2021: 38 · 2020: 36 · 2019: 31 · 2018: 24 · 2017: 19 · 2016: 11
FWCI: 1.44
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Current Opinion in Neurology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Institute of Neurological Disorders and Stroke (R01NS081055, R01NS053957)
Topics: Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
Keywords: blood-brain barrier disruption, neovascularization, stroke, traumatic brain injury, angiogenesis, arteriogenesis, vasculogenesis, vascular repair, caveolae, tight junction disruption, paracellular permeability, functional recovery
MeSH terms: Blood-Brain Barrier, Brain Injuries, Humans, Neovascularization, Physiologic, Stroke

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Blood−brain barrier breakdown and neovascularization processes after stroke and traumatic brain injury

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