T-type calcium channels regulate cortical plasticity in-vivo NR-D-08-7049
Open accessAbstract
T-type voltage-dependent calcium channels may play an important role in synaptic plasticity, but lack of specific antagonists has hampered investigation into this possible function. We investigated the role of the T-type channel in a canonical model of in-vivo cortical plasticity triggered by monocular deprivation. We identified a compound (TTA-I1) with subnanomolar potency in standard voltage clamp assays and high selectivity for the T-type channel. When infused intracortically, TTA-I1 reduced cortical plasticity triggered by monocular deprivation while preserving normal visual response properties. These results show that the T-type calcium channel plays a central role in cortical plasticity.
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There is evidence that ODP critically depends on T-type calcium channel function, which also plays an essential role in generating spindles and slow oscillations during non-REM sleep.
“Interestingly, there is evidence that ODP critically depends on the T-type calcium channel function ( 1224), which also plays an essential role in the generation of spindles and slow oscillations during non-REM sleep (282, 283).”
From About Sleep's Role in Memory (2013) · cites this paper as [1224]
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Cites
Bear, M., Kleinschmidt, A., Gu, Q., & Singer, W. (1990) · The Journal of Neuroscience · doi:10.1523/jneurosci.10-03-00909.1990 · Cited by 488 · see citing works
Excitatory-inhibitory balance and critical period plasticity in developing visual cortex
Hensch, T. K., & Fagiolini, M. (2005) · Progress in Brain Research · doi:10.1016/s0079-6123(04)47009-5 · Cited by 267 · see citing works
Goldberg, J. H., Lacefield, C. O., & Yuste, R. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.064519 · Cited by 107 · see citing works
The Non-Benzodiazepine Hypnotic Zolpidem Impairs Sleep-Dependent Cortical Plasticity
(2008) · Sleep · doi:10.5665/sleep/31.10.1381 · Cited by 60 · see citing works
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Research works printed but not linked: 18
- [1]Yunker AMR McEnery MW Low-voltage-activated (‘T-Type’) calcium channels in review J Bioenerg Biomembr 2003 35 533 575 15000520
- [2]Komatsu Y Iwakiri M Low-threshold Ca2+ channels mediate induction of long-term potentiation in kitten visual cortex J Neurophysiol 1992 67 401 410 1349036
- [3]Yunker AMR Modulation and pharmacology of low voltage-activated (‘T-Type’) calcium channels J Bioenerg Biomembr 2003 35 577 598 15000521
- [4]Hubel DH Wiesel TN The period of susceptibility to the physiological effects of unilateral eye closure in kittens J Physiol 1970 206 419 436 5498493 PMC1348655
- [5]Shipe WD Barrow JC Yang ZQ Lindsley CW Yang FV Schlegel KA Design, synthesis and evaluation of a novel 4-aminomethyl-4-fluoropiperidine as a T-type Ca2+ channel antagonist J Med Chem 2008 51 6471 6477 18540666
- [7]Russell MG Matassa VG Pengilley RP Van Niel MB Sohal B Watt AP 3-[3-(Piperidin-1-yl)propyl]indoles as highly selective h5-HT1D receptor agonists J Med Chem 1999 42 4981 5001 10585208
- [8]Xia M Imredy JP Koblan KS Bennett P Connolly TM State-dependent inhibition of L-type calcium channels: cell-based assay in high-throughput format Anal Biochem 2004 327 74 81 15033513
- [9]Dai G Haedo RJ Warren VA Ratliff KS Bugianesi RM Rush A A high-throughput assay for evaluating state dependence and subtype selectivity of Cav2 calcium channel inhibitors Assay Drug Dev Technol 2008 6 195 212 18471074
- [10]Jha SK Jones BE Coleman T Steinmetz N Law C Griffin G Sleep-dependent plasticity requires cortical activity J Neurosci 2005 25 9266 9274 16207886 PMC6725765
- [11]Crair MC Ruthazer ES Gillespie DC Stryker MP Relationship between the ocular dominance and orientation maps in visual cortex of monocularly deprived cats Neuron 1997 19 307 318 9292721
- [13]Higley MJ Contreras D Cellular mechanisms of suppressive interactions between somatosensory responses In Vivo J Neurophysiol 2007 97 647 658 17065248
- [14]Xia M Imredy JP Santarelli VP Liang HA Condra CL Bennett P Generation and characterization of a cell line with inducible expression of Ca(v)3.2 (T-type) channels Assay Drug Dev Technol 2003 1 637 645 15090236
- [15]Xie X Van Deusen AL Vitko I Babu DA Davies LA Huynh N Validation of high throughput screening assays against three subtypes of Ca(v)3 T-type channels using molecular and pharmacologic approaches Assay Drug Dev Technol 2007 5 191 203 17477828
- [17]Gu W Singer W Involvement of serotonin in developmental plasticity in kitten visual cortex Eur J Neurosci 1994 7 1146 1153 7582087
- [19]Perez-Reyes E Molecular physiology of low-voltage-activated T-type calcium channels Physiol Rev 2003 83 117 161 12506128
- [20]Sejnowski TJ Destexhe A Why do we sleep? Brain Res 2000 886 208 223 11119697
- [21]Benington JH Frank MG Cellular and molecular connections between sleep and synaptic plasticity Prog Neurobiol 2003 69 77 101 12684067
- [23]Steriade M Kryger MH Roth T Dement WC Brain electrical activity and sensory processing during waking and sleep states Principles and Practice of Sleep Medicine Philadelphia Saunders 2005 101 119
Cited by
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Rasch, B., & Born, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00032.2012 · Cited by 2,783 · see citing works
- Authors
- Uebele, V. N., Nuss, C. E., Santarelli, V. P., Garson, S. L., Barrow, J. C., Stauffer, S. R., Koblan, K. S., Renger, J. J., Aton, S., Seibt, J., Dumoulin, M., Jha, S. K., Coleman, T., & Frank, M. G.
- Affiliations
- Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
- University of Pennsylvania (US)
- Corresponding author
- Frank, Marcos G.
- ORCID
- Venue
- NeuroReport
- Published
- 2009-02-18
- Volume
- 20
- Issue
- 3
- Pages
- 257-262
- ISSN
- 0959-4965 (ISSN-L)
- PMC
- PMC2902375
- OpenAlex
- W2037908792
- Cited by
- 21
- References
- 4
- Citations by year
- 2023: 1 · 2022: 1 · 2021: 2 · 2020: 2 · 2017: 1 · 2016: 1 · 2014: 2 · 2013: 2
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (5-R01-MH067568, R01MH067568)
- National Eye Institute (F32EY017766)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- T-type calcium channels, cortical plasticity, monocular deprivation, calcium channel blockers, synaptic plasticity, visual cortex, visual response properties
- MeSH terms
- Animals, Calcium Channel Blockers, Cats, Cell Line, Humans, Indoles, Membrane Potentials, Neuronal Plasticity, Sensory Deprivation, Triazoles, Visual Cortex, Visual Pathways, Visual Perception, Vision, Monocular, Patch-Clamp Techniques, Calcium Channels, T-Type, Dominance, Ocular
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