The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Treadmill exercise elevates striatal dopamine D2 receptor binding potential in patients with early Parkinson's disease
Abstract
We have previously demonstrated changes in dopaminergic neurotransmission after intensive exercise in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse model of Parkinson's disease (PD), including an increase in the dopamine D2 receptor (DA-D2R), using noninvasive PET imaging with the radioligand [18F]fallypride. The purpose of this feasibility and translational study was to examine whether intensive exercise leads to similar alterations in DA-D2R expression using PET imaging with [18F]fallypride in individuals with early-stage PD. In this pilot study, four patients with early-stage PD were randomized to receive intensive exercise (treadmill training sessions three times/week for 8 weeks) or no exercise. Two healthy age-matched individuals participated in treadmill training. Alterations in the DA-D2R binding potential (BP) as a marker for receptor expression were determined using PET imaging with [18F]fallypride. Turning performance in the patients with PD as a measure of postural control and the Unified Parkinson's Disease Rating Scale scores pre-exercise and postexercise were determined. Our data showed an exercise-induced increase in [18F]fallypride BP as well as improved postural control in patients with PD who exercised. Changes in DA-D2R BP were not observed in patients with PD who did not exercise. These results suggest that exercise can lead to neuroplasticity in dopaminergic signaling and contribute to improved function that may be task specific (postural control) in early-stage PD.
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“Consistent with this notion, studies in animals have shown that brain changes seen in exercise are distinct from those observed in learning 52.”
From Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease (2013) · cites this paper as [52]
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“Interestingly, rats that have undergone aerobic exercise have an increase in the density of capillaries in the cerebral motor regions, without an increase in the number of synapses, but display improved cortical related behaviors52.”
From Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease (2013) · cites this paper as [52]
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Metadata
- Authors
- Fisher, B. E., Li, Q., Nacca, A., Salem, G. J., Song, J., Yip, J., Hui, J. S., Jakowec, M. W., & Petzinger, G. M.
- Affiliations
- University of Southern California (US)
- Corresponding author
- Petzinger, Giselle M.
- ORCID
- Venue
- Neuroreport
- Published
- 2013-07-10
- Volume
- 24
- Issue
- 10
- Pages
- 509-514
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W2037477382
- Cited by
- 247
- References
- 28
- Citations by year
- 2026: 9 · 2025: 23 · 2024: 24 · 2023: 18 · 2022: 24 · 2021: 10 · 2020: 25 · 2019: 16 · 2018: 25 · 2017: 18 · 2016: 19 · 2015: 21 · 2014: 11 · 2013: 3
- FWCI
- 11.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- OPUS - Open Publications of UTS Scholars (University of Technology Sydney) (submittedVersion)
- Funders
- Siemens Medical Solutions USA
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- Parkinson's disease, treadmill exercise, dopamine D2 receptor, [18F]fallypride, receptor binding potential, dopamine signaling, postural control, turning performance, neuroplasticity, early-stage Parkinson's disease, exercise therapy
- MeSH terms
- Benzamides, Biomechanical Phenomena, Brain, Exercise Therapy, Female, Gait, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuronal Plasticity, Parkinson Disease, Pilot Projects, Posture, Psychomotor Performance, Pyrrolidines, Neostriatum, Receptors, Dopamine D2, Radiopharmaceuticals, Positron-Emission Tomography
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