Cited by 247Parkinson's Disease Mechanisms and TreatmentsDeep Brain Stimulation and Movement DisordersNeurotransmitter Receptor Influence on Behavior

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Treadmill exercise elevates striatal dopamine D2 receptor binding potential in patients with early Parkinson's disease

Fisher, Beth E., Li, Quanzheng, Nacca, Angelo, Salem, George J., Song, Jooeun, Yip, Jeanine, Hui, Jennifer S., Jakowec, Michael W., Petzinger, Giselle M.·2013·Neuroreport

DOI 10.1097/wnr.0b013e328361dc13

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Abstract

We have previously demonstrated changes in dopaminergic neurotransmission after intensive exercise in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse model of Parkinson's disease (PD), including an increase in the dopamine D2 receptor (DA-D2R), using noninvasive PET imaging with the radioligand [18F]fallypride. The purpose of this feasibility and translational study was to examine whether intensive exercise leads to similar alterations in DA-D2R expression using PET imaging with [18F]fallypride in individuals with early-stage PD. In this pilot study, four patients with early-stage PD were randomized to receive intensive exercise (treadmill training sessions three times/week for 8 weeks) or no exercise. Two healthy age-matched individuals participated in treadmill training. Alterations in the DA-D2R binding potential (BP) as a marker for receptor expression were determined using PET imaging with [18F]fallypride. Turning performance in the patients with PD as a measure of postural control and the Unified Parkinson's Disease Rating Scale scores pre-exercise and postexercise were determined. Our data showed an exercise-induced increase in [18F]fallypride BP as well as improved postural control in patients with PD who exercised. Changes in DA-D2R BP were not observed in patients with PD who did not exercise. These results suggest that exercise can lead to neuroplasticity in dopaminergic signaling and contribute to improved function that may be task specific (postural control) in early-stage PD.

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Authors: Fisher, B. E., Li, Q., Nacca, A., Salem, G. J., Song, J., Yip, J., Hui, J. S., Jakowec, M. W., & Petzinger, G. M.
Affiliations: University of Southern California (US)
Corresponding author: Petzinger, Giselle M.
ORCID: Fisher, Beth E.
Li, Quanzheng
Salem, George J.
Song, Jooeun
Jakowec, Michael W.
Petzinger, Giselle M.
Venue: Neuroreport
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2013-07-10
Volume: 24
Issue: 10
Pages: 509-514
ISSN: 0959-4965 (ISSN-L)
DOI: 10.1097/wnr.0b013e328361dc13
OpenAlex: W2037477382
Cited by: 247
References: 28
Citations by year: 2026: 9 · 2025: 23 · 2024: 24 · 2023: 18 · 2022: 24 · 2021: 10 · 2020: 25 · 2019: 16 · 2018: 25 · 2017: 18 · 2016: 19 · 2015: 21 · 2014: 11 · 2013: 3
FWCI: 11.42
Type: journal article
Language: en
Open access: closed
Locations: Neuroreport (publishedVersion)
PubMed (publishedVersion)
OPUS - Open Publications of UTS Scholars (University of Technology Sydney) (submittedVersion)
Funders: Siemens Medical Solutions USA
Topics: Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: Parkinson's disease, treadmill exercise, dopamine D2 receptor, [18F]fallypride, receptor binding potential, dopamine signaling, postural control, turning performance, neuroplasticity, early-stage Parkinson's disease, exercise therapy
MeSH terms: Benzamides, Biomechanical Phenomena, Brain, Exercise Therapy, Female, Gait, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuronal Plasticity, Parkinson Disease, Pilot Projects, Posture, Psychomotor Performance, Pyrrolidines, Neostriatum, Receptors, Dopamine D2, Radiopharmaceuticals, Positron-Emission Tomography

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Treadmill exercise elevates striatal dopamine D2 receptor binding potential in patients with early Parkinson's disease

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