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Cited by 175Sexual function and dysfunction studiesSchizophrenia research and treatmentTreatment of Major Depression

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.

Sexual side-effects of antidepressant and antipsychotic drugs

Montejo, Angel L., Montejo, Laura, Navarro-Cremades, Felipe·2015·Current Opinion in Psychiatry
DOI 10.1097/yco.0000000000000198
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Abstract

PURPOSE OF REVIEW: Psychotropic-related sexual dysfunction is a quite frequent issue in clinical practice, mainly in chronic treatments affecting both quality of life and compliance. RECENT FINDINGS: In the last decade fortunately antidepressants and antipsychotic compounds have been deeply screened in order to identify sexual adverse events that were commonly underdiagnosed and previously underestimated by clinicians and perhaps by pharmaceutical companies as well. Some differences in the mechanism of action are the nucleus of this poorly tolerated adverse event. All antidepressants with serotonergic activity can cause mild to severe sexual dysfunction such as decreased libido and delayed orgasm frequently (>60%) or anorgasmia and arousal difficulties sometimes (30%). In contrast, noradrenergic, dopaminergic, or melatonergic antidepressants do not cause sexual dysfunction but perhaps the clinical profile of patients receiving these compounds could be different. Antipsychotics that highly increase prolactin levels and strongly block dopamine receptors could be related to sexual dysfunction as well. Unfortunately, these dysfunctions are present during the long term after the antipsychotic onset to provide continued symptom control and enable recovery. Young patients suffering psychosis and concomitant sexual dysfunction (erectile and/or orgasmic difficulties) tend to show poor compliance in chronic treatments affecting the outcomes. SUMMARY: The implications of psychotropic-related sexual dysfunction in clinical practice are relevant mainly in patients under long-term treatment with previous satisfactory sexual life. Implications for future research about sexual dysfunction in all new treatments should be strongly taken into account.

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Research works printed but not linked: 10

  1. Clayton, 2006, J Clin Psychiatry, 67, 33
  2. Bijlsma, 2014, Behav, 121, 88
  3. Montejo, 2001, J Clin Psychiatry, 62, 10
  4. Montejo, 2000, Actas Esp Psiquiatr, 28, 141
  5. Citrome, 2012, Pract, 66, 356
  6. Dording, 2015, Evid Based Compl Altern Med, 2015, 949036
  7. Baldwin, 2013, Depress Res Treat, 2013, 256841
  8. Clayton, 1997, Psychopharmacol Bull, 33, 731
  9. Montejo, 2014, Eur Psychiatry, 29, 1
  10. Meng, 25, Erratum in: Shanghai Arch Psychiatry 2 Apr, 27, 89

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Metadata

Authors
Montejo, A. L., Montejo, L., & Navarro-Cremades, F.
Affiliations
  • Universidad de Salamanca (ES)
  • Universitat de Miguel Hernández d'Elx (ES)
Corresponding author
  • Montejo, Angel L.
  • Montejo, Laura
ORCID
Venue
Current Opinion in Psychiatry
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2015-11
Volume
28
Issue
6
Pages
418-423
ISSN
0951-7367 (ISSN-L)
DOI
10.1097/yco.0000000000000198
OpenAlex
W2400902966
Cited by
175
References
43
Citations by year
2026: 8 · 2025: 16 · 2024: 10 · 2023: 23 · 2022: 25 · 2021: 22 · 2020: 13 · 2019: 21 · 2018: 15 · 2017: 13 · 2016: 8 · 2015: 1
FWCI
1.70
Type
journal article
Language
en
Open access
closed
Locations
  • Current Opinion in Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords
sexual dysfunction, antidepressants, antipsychotic drugs, low libido, anorgasmia, prolactin, dopamine receptor blockade, serotonergic antidepressants, noradrenergic antidepressants, melatonergic antidepressants, medication adherence
MeSH terms
Antidepressive Agents, Female, Humans, Erectile Dysfunction, Libido, Male, Orgasm, Psychotic Disorders, Psychotropic Drugs, Quality of Life, Receptors, Dopamine, Receptors, Serotonin, Sexual Behavior, Antipsychotic Agents, Sexual Dysfunctions, Psychological, Medication Adherence

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