Antidepressant‐induced sexual dysfunction

Rothmore, Jody

doi:10.5694/mja2.50522

Cited by 229Sexual function and dysfunction studiesTreatment of Major DepressionSchizophrenia research and treatment

Antidepressant‐induced sexual dysfunction

Rothmore, Jody·2020·Medical Journal of Australia

DOI 10.5694/mja2.50522

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Abstract

Sexual dysfunction is a frequent, potentially distressing, adverse effect of antidepressants and a leading cause of medication non-adherence. Sexual function should be actively assessed at baseline, at regular intervals during treatment, and after treatment cessation. Trials comparing the risk of sexual dysfunction with individual antidepressants are inadequate, but it is reasonable to conclude that the risk is greatest with selective serotonin reuptake inhibitors (SSRIs) and serotonin and noradrenaline reuptake inhibitors (SNRIs), less with tricyclic antidepressants (except clomipramine) and mirtazapine, and least with moclobemide, agomelatine, reboxetine and bupropion. Management of antidepressant-induced sexual dysfunction requires an individualised approach (eg, considering other causes, dose reduction, addition of medication to treat the adverse effect, switching to a different antidepressant). Post-SSRI sexual dysfunction has been recently identified as a potential, although rare, adverse effect of SSRIs and SNRIs. Consider the possibility of post-SSRI sexual dysfunction in patients in whom sexual dysfunction was absent before starting antidepressants but develops during or soon after antidepressant treatment and still persists after remission from depression and discontinuation of the drug.

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Authors: Rothmore, J.
Affiliations: SA Health (AU)
Corresponding author: Rothmore, Jody
Venue: Medical Journal of Australia
Publisher: AMPCo
Published: 2020-03-15
Volume: 212
Issue: 7
Pages: 329-334
ISSN: 0025-729X (ISSN-L)
1326-5377
DOI: 10.5694/mja2.50522
OpenAlex: W3011798246
Cited by: 229
References: 78
Citations by year: 2026: 27 · 2025: 58 · 2024: 52 · 2023: 37 · 2022: 33 · 2021: 20 · 2020: 2
FWCI: 3.80
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
doi.wiley.com/10.1002/tdm_license_1.1 (tdm)
Locations: The Medical Journal of Australia (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords: antidepressant-induced sexual dysfunction, selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, tricyclic antidepressants, mirtazapine, moclobemide, agomelatine, reboxetine, bupropion, medication non-adherence, sexual function assessment, adverse drug reactions, depression remission
MeSH terms: Antidepressive Agents, Humans, Sexual Dysfunction, Physiological, Randomized Controlled Trials as Topic, Disease Management

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Antidepressant‐induced sexual dysfunction

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