Cited by 115Gut microbiota and healthTryptophan and brain disordersGastrointestinal motility and disorders

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Depressed gut? The microbiota-diet-inflammation trialogue in depression

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Koopman, Margreet, El Aidy, Sahar·2017·Current Opinion in Psychiatry

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Abstract

PURPOSE OF REVIEW: According to the WHO reports, around 350 million people worldwide suffer from depression. Despite its high prevalence, the complex interaction of multiple mechanisms underlying depression still needs to be elucidated. RECENT FINDINGS: Over the course of the last few years, several neurobiological alterations have been linked to the development and maintenance of depression. One basic process that seems to link many of these findings is inflammation. Chronic inflammation has been associated with both biological factors such as excessive neurotransmitter concentrations as well as psychological processes such as adult stress reactivity and a history of childhood trauma. As a balanced microbial community, modulated by diet, is a key regulator of the host physiology, it seems likely that gut microbiota plays a role in depression. SUMMARY: The review summarizes the existent literature on this emerging research field and provides a comprehensive overview of the multifaceted links between the microbiota, diet, and depression. Several pathways linking early life trauma, pharmacological treatment effects, and nutrition to the microbiome in depression are described aiming to foster the psychotherapeutic treatment of depressed patients by interventions targeting the microbiota.

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Authors: Koopman, M., & El Aidy, S.
Affiliations: University of Groningen (NL)
ORCID: Koopman, Margreet
Venue: Current Opinion in Psychiatry
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2017-09
Volume: 30
Issue: 5
Pages: 369-377
ISSN: 0951-7367 (ISSN-L)
DOI: 10.1097/yco.0000000000000350
OpenAlex: W2731329638
Semantic Scholar: 4910acbec4711ba169782cd622af8add8ec2c867
Cited by: 114
References: 76
Citations by year: 2026: 6 · 2025: 8 · 2024: 9 · 2023: 15 · 2022: 22 · 2021: 16 · 2020: 20 · 2019: 12 · 2018: 5 · 2017: 1
FWCI: 0.97
Type: journal article
Language: en
Open access: green
research.rug.nl
Licence: other-oa
Locations: Current Opinion in Psychiatry (publishedVersion)
PubMed (publishedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, other-oa)
University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
Funders: European Commission
Rijksuniversiteit Groningen
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: depression, gut microbiota, diet, inflammation, chronic inflammation, early trauma, stress reactivity, neurotransmitters, microbiota-targeted interventions, psychotherapy
MeSH terms: Gastrointestinal Microbiome, Depression, Depressive Disorder, Diet, Humans, Inflammation, Stress, Psychological

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Depressed gut? The microbiota-diet-inflammation trialogue in depression

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