The role of the gut microbiota in the metabolism of polyphenols as characterized by gnotobiotic mice
Open accessAbstract
A growing body of experimental data suggests that microbes in the gut influence behavior and can alter brain physiology and neurochemistry. Although promising, researchers are only starting to understand the potential of the gut microbiota for use in neurological disease. Recent evidence demonstrated that gastrointestinal activities are linked to mood disorders such as anxiety, depression, and most recently, cognitive functions in age-related neurodegenerative disorders. Studies from our group and others are uncovering new evidence suggesting that the gut microbiota plays a crucial role in the metabolism and bioavailability of certain dietary compounds and synthetic drugs. Based on this evidence, this review article will discuss the implications of the gut microbiota in mechanisms of bioavailability and biotransformation with an emphasis on dietary polyphenol compounds. This will be followed by a survey of ongoing innovative research identifying the ability of individual gut bacteria to enhance the bioavailability of gut-derived, brain-penetrating, bioactive polyphenol metabolites that ultimately influence mechanisms associated with the promotion of resilience against psychological and cognitive impairment in response to stress. Lastly, current research initiatives aimed at promoting the generation of brain bioactive polyphenol metabolites by specialized gut microbes will be discussed, specifically the use of gnotobiotic mice to develop bioengineered second generation probiotics. We propose that leveraging the gut microbial ecosystem to generate brain targeted bioactive metabolites from dietary polyphenols can attenuate lifestyle risk factors and promote resilience against age-related cognitive decline.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Other microbial metabolites, including bioactive molecules produced from metabolism of polyphenols and phenolic compounds as well as phytates, mediate gut-brain communication.
“Other microbial metabolites are being discovered to mediate the gut-brain communication, including bioactive molecules produced from the metabolism of polyphenols and phenolic compounds as well as phytates (413).”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [413]
Bioavailability and some biological activity of ω-3 fatty acids or polyphenols might be dependent on conversion by the gut microbiota.
“However, bioavailability and some biological activity might also be dependent on conversion by the gut microbiota (413), which is the case in the interaction between polyphenols, microbiota, and associated beneficial effects (507).”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [413]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Microbiome restoration diet improves digestion, cognition and physical and emotional wellbeing
Lawrence, K., & Hyde, J. (2017) · PLOS ONE · doi:10.1371/journal.pone.0179017 · Cited by 34 · see citing works
RetractedStructure, function and diversity of the healthy human microbiome
The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11234 · Cited by 11,726 · see citing works
A human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624 · see citing works
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,501 · see citing works
A core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823 · see citing works
Human gut microbiome viewed across age and geography
Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815 · see citing works
Enterotypes of the human gut microbiome
MetaHIT Consortium (additional members), Arumugam, M., Raes, J., Pelletier, E., Le Paslier, D., Yamada, T., Mende, D. R., Fernandes, G. R., Tap, J., Bruls, T., et al. (2011) · Nature · doi:10.1038/nature09944 · Cited by 7,548 · see citing works
Oxidative stress, inflammation, and cancer: How are they linked?
Reuter, S., Gupta, S. C., Chaturvedi, M. M., & Aggarwal, B. B. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.09.006 · Cited by 5,441 · see citing works
The gut microbiota shapes intestinal immune responses during health and disease
Round, J. L., & Mazmanian, S. K. (2009) · Nature Reviews Immunology · doi:10.1038/nri2515 · Cited by 5,029 · see citing works
A Meta-Analysis of Cytokines in Major Depression
Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.033 · Cited by 4,729 · see citing works
Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies
Manach, C., Williamson, G., Morand, C., Scalbert, A., & Rémésy, C. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.230s · Cited by 4,219 · see citing works
Commensal <i>Bifidobacterium</i> promotes antitumor immunity and facilitates anti–PD-L1 efficacy
Sivan, A., Corrales, L., Hubert, N., Williams, J. B., Aquino-Michaels, K., Earley, Z. M., Benyamin, F. W., Man Lei, Y., Jabri, B., Alegre, M.-L., et al. (2015) · Science · doi:10.1126/science.aac4255 · Cited by 3,888 · see citing works
Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice
Ridaura, V. K., Faith, J. J., Rey, F. E., Cheng, J., Duncan, A. E., Kau, A. L., Griffin, N. W., Lombard, V., Henrissat, B., Bain, J. R., et al. (2013) · Science · doi:10.1126/science.1241214 · Cited by 3,788 · see citing works
Self-citationThe Effect of Diet on the Human Gut Microbiome: A Metagenomic Analysis in Humanized Gnotobiotic Mice
Turnbaugh, P. J., Ridaura, V. K., Faith, J. J., Rey, F. E., Knight, R., & Gordon, J. I. (2009) · Science Translational Medicine · doi:10.1126/scitranslmed.3000322 · Cited by 3,058 · see citing works
Self-citationGut microbiota functions: metabolism of nutrients and other food components
Rowland, I., Gibson, G., Heinken, A., Scott, K., Swann, J., Thiele, I., & Tuohy, K. (2018) · European Journal of Nutrition · doi:10.1007/s00394-017-1445-8 · Cited by 2,878 · see citing works
Del Rio, D., Rodriguez-Mateos, A., Spencer, J. P. E., Tognolini, M., Borges, G., & Crozier, A. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4581 · Cited by 2,601 · see citing works
Oxidative Stress and Inflammation: What Polyphenols Can Do for Us?
Hussain, T., Tan, B., Yin, Y., Blachier, F., Tossou, M. C. B., & Rahu, N. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/7432797 · Cited by 2,088 · see citing works
The Long-Term Stability of the Human Gut Microbiota
Faith, J. J., Guruge, J. L., Charbonneau, M., Subramanian, S., Seedorf, H., Goodman, A. L., Clemente, J. C., Knight, R., Heath, A. C., Leibel, R. L., et al. (2013) · Science · doi:10.1126/science.1237439 · Cited by 2,058 · see citing works
Self-citationCharacteristics Associated with Liver Graft Failure: The Concept of a Donor Risk Index
Feng, S., Goodrich, N. P., Bragg‐Gresham, J. L., Dykstra, D. M., Punch, J. D., DebRoy, M. A., Greenstein, S., & Merion, R. M. (2006) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2006.01242.x · Cited by 1,959 · see citing works
Reconsidering anhedonia in depression: Lessons from translational neuroscience
Treadway, M. T., & Zald, D. H. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.06.006 · Cited by 1,579 · see citing works
The central nervous system and the gut microbiome
Sharon, G., Sampson, T. R., Geschwind, D. H., & Mazmanian, S. K. (2016) · Cell · doi:10.1016/j.cell.2016.10.027 · Cited by 1,513 · see citing works
Signals from the gut microbiota to distant organs in physiology and disease
Schroeder, B. O., & Bäckhed, F. (2016) · Nature Medicine · doi:10.1038/nm.4185 · Cited by 1,409 · see citing works
Neufeld, K. M., Kang, N., Bienenstock, J., & Foster, J. A. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2010.01620.x · Cited by 1,392 · see citing works
Minireview: Gut microbiota: The neglected endocrine organ
Clarke, G., Stilling, R. M., Kennedy, P. J., Stanton, C., Cryan, J. F., & Dinan, T. G. (2014) · Molecular Endocrinology · doi:10.1210/me.2014-1108 · Cited by 1,192 · see citing works
Mediterranean diet and risk for Alzheimer's disease
Scarmeas, N., Stern, Y., Tang, M., Mayeux, R., & Luchsinger, J. A. (2006) · Annals of Neurology · doi:10.1002/ana.20854 · Cited by 1,103 · see citing works
Gut Microbiota and Extreme Longevity
Biagi, E., Franceschi, C., Rampelli, S., Severgnini, M., Ostan, R., Turroni, S., Consolandi, C., Quercia, S., Scurti, M., Monti, D., et al. (2016) · Current Biology · doi:10.1016/j.cub.2016.04.016 · Cited by 1,025 · see citing works
Major depressive disorder: new clinical, neurobiological, and treatment perspectives
Kupfer, D. J., Frank, E., & Phillips, M. L. (2012) · The Lancet · doi:10.1016/s0140-6736(11)60602-8 · Cited by 894 · see citing works
Microbiota and diabetes: an evolving relationship
Tilg, H., & Moschen, A. R. (2014) · Gut · doi:10.1136/gutjnl-2014-306928 · Cited by 853 · see citing works
The Gut Microbiota and Alzheimer’s Disease
Jiang, C., Li, G., Huang, P., Liu, Z., & Zhao, B. (2017) · Journal of Alzheimer's Disease · doi:10.3233/jad-161141 · Cited by 852 · see citing works
Bäckhed, F., Fraser, C. M., Ringel, Y., Sanders, M. E., Sartor, R. B., Sherman, P. M., Versalovic, J., Young, V., & Finlay, B. B. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.10.012 · Cited by 836 · see citing works
Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration
Dinan, T. G., & Cryan, J. F. (2017) · The Journal of Physiology · doi:10.1113/jp273106 · Cited by 813 · see citing works
The Reciprocal Interactions between Polyphenols and Gut Microbiota and Effects on Bioaccessibility
Özdal, T., Sela, D. A., Xiao, J., Boyacıoğlu, D., Chen, F., & Çapanoğlu, E. (2016) · Nutrients · doi:10.3390/nu8020078 · Cited by 812 · see citing works
Goodman, A. L., Kallstrom, G., Faith, J. J., Reyes, A., Moore, A. M., Dantas, G. A., & Gordon, J. I. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102938108 · Cited by 779 · see citing works
Self-citationBioavailability of Dietary Polyphenols and Gut Microbiota Metabolism: Antimicrobial Properties
Marín, L., Miguélez, E. M., Villar, C. J., & Lombó, F. (2015) · BioMed Research International · doi:10.1155/2015/905215 · Cited by 778 · see citing works
The gut microbiota: a key factor in the therapeutic effects of (poly)phenols
Espín, J. C., González-Sarrías, A., & Tomás-Barberán, F. A. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.04.033 · Cited by 603 · see citing works
Monagas, M., Urpí-Sardà, M., Sánchez‐Patán, F., Llorach, R., Garrido, I., Gómez‐Cordovés, C., Andrés‐Lacueva, C., & Bartolomé, B. (2010) · Food & Function · doi:10.1039/c0fo00132e · Cited by 600 · see citing works
Microbiome, probiotics and neurodegenerative diseases: deciphering the gut brain axis
Westfall, S., Lomis, N., Kahouli, I., Dia, S. Y., Singh, S. P., & Prakash, S. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2550-9 · Cited by 551 · see citing works
Self-citationNeuroprotective potential of phytochemicals
Kumar, G., & Khanum, F. (2012) · Pharmacognosy Reviews/Bioinformatics Trends/Pharmacognosy review · doi:10.4103/0973-7847.99898 · Cited by 526 · see citing works
Microbiota and host determinants of behavioural phenotype in maternally separated mice
De Palma, G., Blennerhassett, P., Lu, J., Deng, Y., Park, A. J., Green, W., Denou, E., Silva, M. A., Santacruz, A., Sanz, Y., et al. (2015) · Nature Communications · doi:10.1038/ncomms8735 · Cited by 517 · see citing works
The role of metabolism (and the microbiome) in defining the clinical efficacy of dietary flavonoids
Cassidy, A., & Minihane, A. M. (2016) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.136051 · Cited by 513 · see citing works
The microbiome: a key regulator of stress and neuroinflammation
Rea, K., Dinan, T. G., & Cryan, J. F. (2016) · Neurobiology of Stress · doi:10.1016/j.ynstr.2016.03.001 · Cited by 508 · see citing works
The microbiota-gut-brain axis in obesity.
Torres-Fuentes, C., Schellekens, H., Dinan, T., & Cryan, J. (2017) · The Lancet Gastroenterology and Hepatology · doi:10.1016/s2468-1253(17)30147-4 · Cited by 506 · see citing works
A dynamic partnership: Celebrating our gut flora
Sears, C. L. (2005) · Anaerobe · doi:10.1016/j.anaerobe.2005.05.001 · Cited by 415 · see citing works
Metabolic niche of a prominent sulfate-reducing human gut bacterium
Rey, F. E., Gonzalez, M. D., Cheng, J., Wu, M., Ahern, P. P., & Gordon, J. I. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1312524110 · Cited by 412 · see citing works
In vivo and in vitro metabolism of trans-resveratrol by human gut microbiota
Bode, L. M., Bunzel, D., Huch, M., Cho, G., Ruhland, D., Bunzel, M., Bub, A., Franz, C. M. A. P., & Kulling, S. E. (2013) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.049379 · Cited by 398 · see citing works
Microbiome and metabolic disease: revisiting the bacterial phylum Bacteroidetes
Johnson, E. L., Heaver, S. L., Walters, W. A., & Ley, R. E. (2017) · Journal of Molecular Medicine · doi:10.1007/s00109-016-1492-2 · Cited by 389 · see citing works
Faith, J. J., Ahern, P. P., Ridaura, V. K., Cheng, J., & Gordon, J. I. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008051 · Cited by 373 · see citing works
Self-citationGut microbiota signatures of longevity
Kong, F., Hua, Y., Zeng, B., Ning, R., Li, Y., & Zhao, J. (2016) · Current Biology · doi:10.1016/j.cub.2016.08.015 · Cited by 371 · see citing works
Wang, J., Ho, L., Zhao, W., Ono, K., Rosensweig, C., Chen, L., Humala, N., Teplow, D. B., & Pasinetti, G. M. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0364-08.2008 · Cited by 358 · see citing works
Self-citationRecent developments in understanding the role of the gut microbiota in brain health and disease
Sherwin, E., Dinan, T. G., & Cryan, J. F. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13416 · Cited by 338 · see citing works
Fecal microbial metabolism of polyphenols and its effects on human gut microbiota
Parkar, S. G., Trower, T. M., & Stevenson, D. E. (2013) · Anaerobe · doi:10.1016/j.anaerobe.2013.07.009 · Cited by 317 · see citing works
Selma, M. V., Beltrán, D., García-Villalba, R., Espín, J. C., & Tomás-Barberán, F. A. (2014) · Food Funct. · doi:10.1039/c4fo00092g · Cited by 304 · see citing works
Yarandi, S., Peterson, D. A., Treisman, G. J., Moran, T. H., & Pasricha, P. J. (2016) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm15146 · Cited by 294 · see citing works
Ferulic Acid: A Hope for Alzheimer’s Disease Therapy from Plants
Sgarbossa, A., Giacomazza, D., & Carlo, M. D. (2015) · Nutrients · doi:10.3390/nu7075246 · Cited by 285 · see citing works
Fruit Polyphenols: A Review of Anti-inflammatory Effects in Humans
Joseph, S. V., Edirisinghe, I., & Burton‐Freeman, B. M. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2013.767221 · Cited by 282 · see citing works
Wang, J., Hodes, G. E., Zhang, H., Zhang, S., Zhao, W., Golden, S. A., Bi, W., Menard, C., Kana, V., Leboeuf, M., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02794-5 · Cited by 274 · see citing works
Self-citationThe microbiome, immunity, and schizophrenia and bipolar disorder.
Dickerson, F., Severance, E., & Yolken, R. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.12.010 · Cited by 268 · see citing works
van Vliet, M. J., Tissing, W. J. E., Dun, C. A. J., Meessen, N. E. L., Kamps, W. A., de Bont, E. S. J. M., & Harmsen, H. J. M. (2009) · Clinical Infectious Diseases · doi:10.1086/599346 · Cited by 265 · see citing works
2,2-Diphenyl-1-picrylhydrazyl Radical-Scavenging Active Components from Polygonum multiflorum Thunb.
Chen, Y., Wang, M., Rosen, R. T., et al. (1999) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf990092f · Cited by 263 · see citing works
GABAB Receptors, Schizophrenia and Sleep Dysfunction
Kantrowitz, J., Citrome, L., & Javitt, D. (2009) · CNS Drugs · doi:10.2165/00023210-200923080-00001 · Cited by 260 · see citing works
Bioactive Compounds in Cranberries and their Biological Properties
Côté, J., Caillet, S., Doyon, G., Sylvain, J.-F., & Lacroix, M. (2010) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390903044107 · Cited by 259 · see citing works
Tabasco, R., Sánchez‐Patán, F., Monagas, M., Bartolomé, B., Moreno-Arribas, M. V., Peláez, C., & Requena, T. (2011) · Food Microbiology · doi:10.1016/j.fm.2011.06.005 · Cited by 255 · see citing works
Effects of obesity on depression: A role for inflammation and the gut microbiota
Schachter, J., Martel, J., Lin, C.-S., Chang, C., Wu, T.-R., Lu, C., Ko, Y., Lai, H., Ojcius, D. M., & Young, J. D. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.08.026 · Cited by 252 · see citing works
Neural representation of reward in recovered depressed patients
McCabe, C., Cowen, P. J., & Harmer, C. J. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1573-9 · Cited by 248 · see citing works
Casacalenda, N., Perry, J. C., & Looper, K. J. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.8.1354 · Cited by 247 · see citing works
Jeon, S. W., & Kim, Y. K. (2016) · World Journal of Psychiatry · doi:10.5498/wjp.v6.i3.283 · Cited by 247 · see citing works
Entsuah, A. R., Huang, H., & Thase, M. E. (2001) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v62n1106 · Cited by 245 · see citing works
Tomasello, G., Mazzola, M., Leone, A., Sinagra, E., Zummo, G., Farina, F., Damiani, P., Cappello, F., Geagea, A. G., Jurjus, A. R., et al. (2016) · Biomedical Papers · doi:10.5507/bp.2016.052 · Cited by 243 · see citing works
Energetics and Oxidative Stress in Synaptic Plasticity and Neurodegenerative Disorders
Mattson, M. P., & Liu, D. (2002) · NeuroMolecular Medicine · doi:10.1385/nmm:2:2:215 · Cited by 242 · see citing works
Grapes and Cardiovascular Disease
Dohadwala, M. M., & Vita, J. A. (2009) · Journal of Nutrition · doi:10.3945/jn.109.107474 · Cited by 235 · see citing works
Isolation of catechin-converting human intestinal bacteria
Kutschera, M., Engst, W., Blaut, M., & Braune, A. (2011) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2011.05025.x · Cited by 233 · see citing works
Gut microbiota and autism: key concepts and findings
Ding, H. T., Taur, Y., & Walkup, J. T. (2017) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-016-2960-9 · Cited by 232 · see citing works
Wang, D., Ho, L., Faith, J. J., Ono, K., Janle, E. M., Lachcik, P. J., Cooper, B. R., Jannasch, A., D’Arcy, B., Williams, B. A., et al. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400544 · Cited by 227 · see citing works
Self-citationMarshall, J. K., Thabane, M., Garg, A. X., Clark, W. F., Moayyedi, P., Collins, S. M., & Walkerton Health Study Investigators (2010) · Gut · doi:10.1136/gut.2009.202234 · Cited by 227 · see citing works
The tantalizing links between gut microbes and the brain
Smith, P. A. (2015) · Nature · doi:10.1038/526312a · Cited by 221 · see citing works
Natural Phyto-Bioactive Compounds for the Treatment of Type 2 Diabetes: Inflammation as a Target
Gothai, S., Ganesan, P., Park, S., Fakurazi, S., Choi, D., & Arulselvan, P. (2016) · Nutrients · doi:10.3390/nu8080461 · Cited by 213 · see citing works
Clavel, T., Henderson, G., Engst, W., Dore, J. M., & Blaut, M. (2006) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2005.00057.x · Cited by 209 · see citing works
Review: Mechanisms of How the Intestinal Microbiota Alters the Effects of Drugs and Bile Acids
Klaassen, C. D., & Cui, J. Y. (2015) · Drug Metabolism and Disposition · doi:10.1124/dmd.115.065698 · Cited by 208 · see citing works
Brain-Targeted Proanthocyanidin Metabolites for Alzheimer's Disease Treatment
Wang, J., Ferruzzi, M. G., Ho, L., Blount, J. W., Janle, E. M., Gong, B., Pan, Y., Gowda, G. A. N., Raftery, D., Arrieta‐Cruz, I., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.6437-11.2012 · Cited by 206 · see citing works
Self-citationHo, L., Ferruzzi, M. G., Janle, E. M., Wang, J., Gong, B., Chen, T., Lobo, J., Cooper, B. R., Wu, Q. L., Talcott, S. T., et al. (2012) · The FASEB Journal · doi:10.1096/fj.12-212118 · Cited by 204 · see citing works
Self-citationMediterranean diet and cognitive decline
Panza, F., Solfrizzi, V., Colacicco, A., D’Introno, A., Capurso, C. A., Torres, F., Parigi, A., Capurso, S. A., & Capurso, C. A. (2004) · Public Health Nutrition · doi:10.1079/phn2004561 · Cited by 204 · see citing works
Yan, H., Lu, J., Wang, Y., Gu, W., Yang, X., & Yu, J. (2017) · Phytomedicine · doi:10.1016/j.phymed.2017.01.007 · Cited by 203 · see citing works
Effects of Grape Seed-derived Polyphenols on Amyloid β-Protein Self-assembly and Cytotoxicity*
Ono, K., Condron, M. M., Ho, L., Wang, J., Zhao, W., Pasinetti, G. M., & Teplow, D. B. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806154200 · Cited by 190 · see citing works
Self-citationBioavailability and catabolism of green tea flavan-3-ols in humans
Rio, D. D., Calani, L., Cordero, C. E. I., Salvatore, S., Pellegrini, N., & Brighenti, F. (2010) · Nutrition · doi:10.1016/j.nut.2009.09.021 · Cited by 189 · see citing works
Cueva, C., Sánchez‐Patán, F., Monagas, M., Walton, G., Gibson, G. R., Martín‐Álvarez, P. J., Bartolomé, B., & Moreno-Arribas, M. V. (2012) · FEMS Microbiology Ecology · doi:10.1111/1574-6941.12037 · Cited by 186 · see citing works
Sánchez‐Patán, F., Cueva, C., Monagas, M., Walton, G., M., G. R. G., Quintanilla-López, J. E., Lebrón‐Aguilar, R., Martín-Álvarez, P. J., Moreno-Arribas, M. V., & Bartolomé, B. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf2040115 · Cited by 177 · see citing works
Stoupi, S., Williamson, G., Drynan, J. W., Barron, D., & Clifford, M. N. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200900123 · Cited by 177 · see citing works
Gross, G., Jacobs, D. M., Peters, S., Possemiers, S., van Duynhoven, J., Vaughan, E. E., & de Wiele, T. V. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf101475m · Cited by 176 · see citing works
Biosynthesis of caffeic acid in Escherichia coli using its endogenous hydroxylase complex
Lin, Y., & Yan, Y. (2012) · Microbial Cell Factories · doi:10.1186/1475-2859-11-42 · Cited by 173 · see citing works
Vendrame, S., & Klimis‐Zacas, D. J. (2015) · Nutrition Reviews · doi:10.1093/nutrit/nuu066 · Cited by 168 · see citing works
Cenit, M. C., Nuevo, I. C., Codoñer-Franch, P., Dinan, T. G., & Sanz, Y. (2017) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-017-0969-z · Cited by 163 · see citing works
The gut microbiome and mental health: implications for anxiety- and trauma-related disorders
Malan-Muller, S., Valles-Colomer, M., Raes, J., Lowry, C. A., Seedat, S., & Hemmings, S. M. J. (2018) · OMICS: A Journal of Integrative Biology · doi:10.1089/omi.2017.0077 · Cited by 161 · see citing works
Winter, A. N., Brenner, M. C., Punessen, N., Snodgrass, M., Byars, C., Arora, Y., & Linseman, D. A. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/6297080 · Cited by 160 · see citing works
Rojo, D., Méndez–García, C., Raczkowska, B. A., Bargiela, R., Moyá, A., Ferrer, M., & Barbas, C. (2016) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuw046 · Cited by 159 · see citing works
Dall’Asta, M., Calani, L., Tedeschi, M., Jechiu, L., Brighenti, F., & Rio, D. D. (2011) · Nutrition · doi:10.1016/j.nut.2011.06.005 · Cited by 156 · see citing works
Metagenomic binning and association of plasmids with bacterial host genomes using DNA methylation
Beaulaurier, J., Zhu, S., Deikus, G. Y., Mogno, I., Zhang, X., Davis‐Richardson, A. G., Canepa, R., Triplett, E. W., Faith, J. J., Sebra, R., et al. (2017) · Nature Biotechnology · doi:10.1038/nbt.4037 · Cited by 154 · see citing works
Self-citationFerulic Acid Improves Cardiovascular and Kidney Structure and Function in Hypertensive Rats
Alam, M. A., Sernia, C., & Brown, L. (2013) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e31827cb600 · Cited by 152 · see citing works
Liu, Q., Chen, Y., Shen, C., Xiao, Y., Wang, Y., Liu, Z., & Liu, X. (2016) · The FASEB Journal · doi:10.1096/fj.201601071r · Cited by 146 · see citing works
Phytochemical constituents as future antidepressants: a comprehensive review
Bahramsoltani, R., Farzaei, M. H., Farahani, M. S., & Rahimi, R. (2015) · Reviews in the Neurosciences · doi:10.1515/revneuro-2015-0009 · Cited by 144 · see citing works
Wang, J., Bi, W., Cheng, A., Freire, D., Vempati, P., Zhao, W., Gong, B., Janle, E. M., Chen, T., Ferruzzi, M. G., et al. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00042 · Cited by 126 · see citing works
Self-citationManderino, L., Carroll, I., Azcarate-Peril, M. A., Rochette, A., Heinberg, L., Peat, C., Steffen, K., Mitchell, J., & Gunstad, J. (2017) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617717000492 · Cited by 125 · see citing works
Grape Derived Polyphenols Attenuate Tau Neuropathology in a Mouse Model of Alzheimer's Disease
Wang, J., Santa‐María, I., Ho, L., Ksiȩżak-Reding, H., Ono, K., Teplow, D. B., & Pasinetti, G. M. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-101074 · Cited by 121 · see citing works
Self-citationDepressed gut? The microbiota-diet-inflammation trialogue in depression
Koopman, M., & El Aidy, S. (2017) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000350 · Cited by 114 · see citing works
Knockaert, G., Pulissery, S. K., Lemmens, L., Van Buggenhout, S., Hendrickx, M., & Van Loey, A. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf3025776 · Cited by 108 · see citing works
Yu, W., Ma, M., Chen, X., et al. (2017) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x1750001x · Cited by 102 · see citing works
di Gesso, J. L., Kerr, J. S., Zhang, Q., Raheem, S., Yalamanchili, S. K., O’Hagan, D., Kay, C. D., & O'Connell, M. A. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400799 · Cited by 96 · see citing works
Pasinetti, G. M., Wang, J., Marambaud, P., Ferruzzi, M. G., Gregor, P., Knable, L. A., & Ho, L. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.08.014 · Cited by 96 · see citing works
Self-citationWang, Y., Huo, Y., Zhao, L., Lu, F. L., Wang, O., Yang, X., Ji, B., & Zhou, F. L. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201501048 · Cited by 93 · see citing works
The Microbiota Is Essential for the Generation of Black Tea Theaflavins-Derived Metabolites
Chen, H., Hayek, S. A., Guzman, J. R., Gillitt, N. D., Ibrahim, S. A., Jobin, C., & Sang, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051001 · Cited by 86 · see citing works
Colonic catabolism of dietary phenolic and polyphenolic compounds from Concord grape juice
Stalmach, A., Edwards, C. A., Wightman, J. D., & Crozier, A. (2012) · Food & Function · doi:10.1039/c2fo30151b · Cited by 85 · see citing works
Grape Seed Polyphenolic Extract as a Potential Novel Therapeutic Agent in Tauopathies
Ho, L., Yemul, S., Wang, J., & Pasinetti, G. M. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-0969 · Cited by 82 · see citing works
Self-citationRelationship between Diet and Non-alcoholic Fatty Liver Disease: A Review Article.
Mirmiran, P., Amirhamidi, Z., Ejtahed, H., Bahadoran, Z., & Azizi, F. (2017) · Europe PMC (PubMed Central) · Cited by 82 · see citing works
Kitamura, H. (2019) · Molecules · doi:10.3390/molecules24234394 · Cited by 81 · see citing works
Human gut microbiota plays a role in the metabolism of drugs
Jourová, L., Anzenbacher, P., & Anzenbacherová, E. (2016) · Biomedical Papers · doi:10.5507/bp.2016.039 · Cited by 75 · see citing works
Aura, A., Mattila, I. M., Hyötyläinen, T., Gopalacharyulu, P. V., Cheynier, V., Souquet, J., Bes, M., Bourvellec, C. L., Guyot, S., & Orešič, M. (2012) · European Journal of Nutrition · doi:10.1007/s00394-012-0391-8 · Cited by 67 · see citing works
Teixeira, L. L., Costa, G. R. O., Dörr, F. A., Ong, T. P., Pinto, E., Lajolo, F. M., & Hassimotto, N. M. A. (2017) · Food & Function · doi:10.1039/c7fo00076f · Cited by 67 · see citing works
Mediterranean diet impact on cardiovascular diseases
Mattioli, A. V., Palmiero, P., Manfrini, O., Puddu, P. E., Nodari, S., Dei, A., Mercuro, G. G., Scrutinio, D., Palermo, P., Sciomer, S., et al. (2017) · Journal of Cardiovascular Medicine · doi:10.2459/jcm.0000000000000573 · Cited by 67 · see citing works
The Influence of Intestinal Tract and Probiotics on the Fate of Orally Administered Drugs.
Stojančević, M., Bojić, G., Al‐Salami, H., & Mikov, M. (2014) · PubMed · Cited by 66 · see citing works
Keyserling, T. C., Samuel-Hodge, C. D., Pitts, S. J., Garcia, B. A., Johnston, L. F., Gizlice, Z., Miller, C. L., Braxton, D. F., Evenson, K. R., Smith, J. C., et al. (2016) · BMC Public Health · doi:10.1186/s12889-016-3370-9 · Cited by 65 · see citing works
Host-microbiome interactions: the aryl hydrocarbon receptor and the central nervous system
Lee, H. U., McPherson, Z. E., Tan, B., Korecka, A., & Pettersson, S. (2016) · Journal of Molecular Medicine · doi:10.1007/s00109-016-1486-0 · Cited by 64 · see citing works
GSPE interferes with tau aggregation in vivo: implication for treating tauopathy
Santa‐María, I., Díaz-Ruiz, C., Ksiȩżak-Reding, H., Chen, A. P., Ho, L., Wang, J., & Pasinetti, G. M. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.09.027 · Cited by 63 · see citing works
Self-citationThe Influence of Intestinal Tract and Probiotics on the Fate of Orally Administered Drugs
(2014) · Current Issues in Molecular Biology · doi:10.21775/cimb.016.055 · Cited by 63 · see citing works
Garcia, G., Nanni, S., Figueira, I., Ivanov, I., McDougall, G. J., Stewart, D., Ferreira, R. B., Pinto, P., Silva, R. F. M., Brites, D. M. T. O., et al. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2016.07.128 · Cited by 62 · see citing works
Piwowarski, J. P., Granica, S., & Kiss, A. K. (2014) · Planta Medica · doi:10.1055/s-0034-1368615 · Cited by 60 · see citing works
Zhao, W., Wang, J., Bi, W., Ferruzzi, M. G., Yemul, S., Freire, D., Mazzola, P., Ho, L., Dubner, L., & Pasinetti, G. M. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.07.023 · Cited by 58 · see citing works
Self-citationWang, J., Varghese, M., Ono, K., Yamada, M., Levine, S., Tzavaras, N., Gong, B., Hurst, W. J., Blitzer, R. D., & Pasinetti, G. M. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-132231 · Cited by 58 · see citing works
Self-citationChoi, K., Son, Y., Hwang, J., et al. (2016) · Pharmaceutical Biology · doi:10.1080/13880209.2016.1266673 · Cited by 58 · see citing works
Schoefer, L., Braune, A., & Blaut, M. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.10.6131-6137.2004 · Cited by 56 · see citing works
Ekbatan, S. S., Iskandar, M. M., Sleno, L., Sabally, K., Khairallah, J., Prakash, S., & Kubow, S. J. (2018) · Foods · doi:10.3390/foods7010008 · Cited by 54 · see citing works
Grape Seed Polyphenolic Extract Specifically Decreases Aβ*56 in the Brains of Tg2576 Mice
Liu, P., Kemper, L. J., Wang, J., et al. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110383 · Cited by 53 · see citing works
Guo, X. D., Shen, L. H., Tong, Y., Zhang, J., Wu, G., He, Q., Yu, S., Ye, X., Zou, L., Zhang, Z., et al. (2013) · Phytomedicine · doi:10.1016/j.phymed.2013.04.002 · Cited by 53 · see citing works
Man, A. W. C., Xia, N., Daiber, A., & Li, H. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14850 · Cited by 51 · see citing works
The Cardioprotective Effect of Protocatechuic Acid on Myocardial Ischemia/Reperfusion Injury
Tang, X., Liu, J., Dong, W., Li, P., Li, L., Lin, C.-R., Zheng, Y., Cong, W., & Hou, J.-C. (2014) · Journal of Pharmacological Sciences · doi:10.1254/jphs.13247fp · Cited by 50 · see citing works
Colonic Metabolism of Polyphenols From Coffee, Green Tea, and Hazelnut Skins
Calani, L., Dall’Asta, M., Derlindati, E., Scazzina, F., Bruni, R., & Rio, D. D. (2012) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e318264e82b · Cited by 48 · see citing works
Meagher, M. W., Johnson, R. R., Young, E. E., Vichaya, E. G., Lunt, S., Hardin, E. A., Connor, M. A., & Welsh, C. J. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2007.05.001 · Cited by 48 · see citing works
Li, C., Suzuki, K., Hung, Y., Yang, M.-S., Yu, C., Lin, S.-P., Hou, Y., & Fang, S. (2017) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x17500458 · Cited by 48 · see citing works
Wang, J., Tang, C. Y., Ferruzzi, M. G., Gong, B., Song, B. J., Janle, E. M., Chen, T., Cooper, B. R., Varghese, M., Cheng, A., et al. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300230 · Cited by 47 · see citing works
Self-citationEvaluation of dietary and lifestyle changes as modifiers of S100β levels in Alzheimer’s disease
D'Cunha, N. M., McKune, A. J., Panagiotakos, D. B., Georgousopoulou, E. N., Thomas, J., Mellor, D. D., & Naumovski, N. (2017) · Nutritional Neuroscience · doi:10.1080/1028415x.2017.1349032 · Cited by 47 · see citing works
Sureda, A., Tejada, S., Bibiloni, M. D. M., Tur, J. A., & Pons, A. (2014) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201015666140813123843 · Cited by 45 · see citing works
Novotny, J. A., Chen, T., Terekhov, A. I., Gebauer, S. K., Baer, D. J., Ho, L., Pasinetti, G. M., & Ferruzzi, M. G. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700043 · Cited by 41 · see citing works
Self-citationMele, L., Carobbio, S., Brindani, N., Curti, C., Rodríguez‐Cuenca, S., Bidault, G., Mena, P. R., Zanotti, I., Vacca, M., Vidal‐Puig, A., et al. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700074 · Cited by 40 · see citing works
Chen, H., Parks, T. A., Chen, X. L., et al. (2011) · Journal of Chromatography A · doi:10.1016/j.chroma.2011.08.056 · Cited by 34 · see citing works
Building research in diet and cognition: The BRIDGE randomized controlled trial
Tussing-Humphreys, L. M., Lamar, M., Blumenthal, J. A., Babyak, M. A., Fantuzzi, G., Blumstein, L. B., Schiffer, L. A., & Fitzgibbon, M. (2017) · Contemporary Clinical Trials · doi:10.1016/j.cct.2017.06.003 · Cited by 34 · see citing works
Polyphenolic compounds for treating neurodegenerative disorders involving protein misfolding
Ho, L., & Pasinetti, G. M. (2010) · Expert Review of Proteomics · doi:10.1586/epr.10.69 · Cited by 33 · see citing works
Self-citationWard, L. M., & Pasinetti, G. M. (2016) · NeuroMolecular Medicine · doi:10.1007/s12017-016-8418-6 · Cited by 28 · see citing works
Self-citationBioengineered Colorectal Cancer Drugs: Orally Delivered Anti-Inflammatory Agents
Urbanska, A. M., Zhang, X., & Prakash, S. (2015) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-015-0528-5 · Cited by 22 · see citing works
The need for evidence-based intake, progress, and outcomes assessment
Achenbach, T. M. (2016) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-016-0926-2 · Cited by 21 · see citing works
Flavonols: Metabolism, Bioavailability, and Health Impacts
Terao, J. (2009) · doi:10.1002/9780470531792.ch8 · Cited by 17 · see citing works
Host‐microbiome interactions in health and disease
O’Mahony, L. (2015) · Clinical Liver Disease · doi:10.1002/cld.484 · Cited by 7 · see citing works
Zur Kenntnis des Pyrokohlensäurediäthylesters
Rauenbusch, E. (1968) · Zeitschrift für Ernährungswissenschaft · doi:10.1007/bf02021990 · Cited by 7 · see citing works
Ho, L., Cheng, H. M., Wang, J., Simon, J. E., Wu, Q., Zhao, D., Carry, E., Ferruzzi, M. G., Faith, J. J., Valcarcel, B. N., et al. (2017) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.7b00412 · Cited by 6 · see citing works
Self-citationTamura, M., Kageyama, D., Honda, N., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0177915 · Cited by 5 · see citing works
The profiles of dysbiotic microbial communities
Brun, P. (2019) · AIMS Microbiology · doi:10.3934/microbiol.2019.1.87 · Cited by 5 · see citing works
Ho, L., Faith, J. J., Ono, K., et al. (2016) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2016.06.402 · Cited by 2 · see citing works
Self-citationO2‐02‐02: Novel Transcriptional Role of APOE4
Theendakara, V. P., Peters-Libeu, C. A., Bredesen, D. E., & Rao, R. V. (2016) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2016.06.400 · Cited by 2 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [95]Smith PA 2015 Brain, meet gut Nature 526 312 26469024
Cited by
Sorted by citations
Diet and depression: Exploring the biological mechanisms of action
Marx, W., Lane, M., Hockey, M., Aslam, H., Berk, M., Walder, K., Borsini, A., Firth, J., Pariante, C. M., Berding, K., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-00925-x · Cited by 685 · see citing works
Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health
Berding, K., Vlckova, K., Marx, W., Schellekens, H., Stanton, C., Clarke, G., Jacka, F., Dinan, T. G., & Cryan, J. F. (2021) · Advances in Nutrition · doi:10.1093/advances/nmaa181 · Cited by 451 · see citing works
Gut microbiota, cognitive frailty and dementia in older individuals: A systematic review
Ticinesi, A., Tana, C., Nouvenne, A., Prati, B., Lauretani, F., & Meschi, T. (2018) · Clinical Interventions in Aging · doi:10.2147/cia.s139163 · Cited by 215 · see citing works
- Authors
- Pasinetti, G. M., Singh, R., Westfall, S., Herman, F., Faith, J., & Ho, L.
- Affiliations
- James J. Peters VA Medical Center (US)
- Icahn School of Medicine at Mount Sinai (US)
- McGill University (CA)
- Corresponding author
- Pasinetti, Giulio Maria
- Venue
- Journal of Alzheimer s Disease
- Publisher
- SAGE Publications
- Published
- 2018-04-24
- Volume
- 63
- Issue
- 2
- Pages
- 409-421
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- PMC
- PMC6021178
- OpenAlex
- W2796649808
- Cited by
- 112
- References
- 155
- Citations by year
- 2026: 15 · 2025: 18 · 2024: 8 · 2023: 7 · 2022: 12 · 2021: 11 · 2020: 20 · 2019: 12 · 2018: 8
- FWCI
- 1.25
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Veterans Affairs (IK6 BX003785)
- National Center for Complementary and Integrative Health (P50AT008661)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- gut microbiota, dietary polyphenols
- MeSH terms
- Gastrointestinal Microbiome, Animals, Germ-Free Life, Humans, Gastrointestinal Tract, Mice, Polyphenols
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review