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Role of expectations in health
Abstract
PURPOSE OF REVIEW: Considerable progress has been made in the neurobiological understanding of expectations in physiological and pathological processes. This article is aimed at presenting an overview of the role of expectations in producing health-related effects. We selected recent laboratory and clinical studies in the field of the placebo effect, with a particular focus on psychiatric disorders. RECENT FINDINGS: Recent scientific research indicates that expectations have the potential for relieving many symptoms. This research relies mostly on the study of placebo and nocebo phenomena which influence physiological and pathological functions. The findings from placebo and nocebo research have important implications for the design and interpretation of clinical trials and for clinical practice. SUMMARY: The studies of expectations in the field of psychiatry and in other fields of medicine suggest that placebo effects are likely to be an important aspect of any treatment. The application of research on health-related expectations has the potential for promoting wellness, improving health, and benefiting patient care.
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“Still, the induction of positive expectations regarding an intervention's outcome using verbal suggestions have frequently been shown to affect numerous health outcomes previously (Colloca & Miller, 2011), for example, in (placebo) pain research (Peerdeman et al., 2016; Vase et al., 2002).”
From Mindfulness Effects on Anxiety: Disentangling the Role of Decentering and Treatment Expectations (2024) · cites this paper as Colloca & Miller, 2011
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Cited by
Sorted by citations
Colloca, L., Ludman, T., Bouhassira, D., Baron, R., Dickenson, A. H., Yarnitsky, D., Freeman, R. L., Truini, A., Attal, N., Finnerup, N. B., et al. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.2 · Cited by 2,271
Self-citation(2020) · doi:10.1056/nejmra1907805 · Cited by 634
Self-citationThe Placebo Effect in Pain Therapies
Colloca, L. (2018) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010818-021542 · Cited by 303
Self-citationLaferton, J. A. C., Kube, T., Salzmann, S., Auer, C. J., & Shedden-Mora, M. C. (2017) · Frontiers in Psychology · doi:10.3389/fpsyg.2017.00233 · Cited by 267
The placebo effect: From concepts to genes
Colagiuri, B., Schenk, L. A., Keßler, M., Dorsey, S. G., & Colloca, L. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.08.017 · Cited by 278
Self-citation
Metadata
- Authors
- Colloca, L., & Miller, F. G.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Colloca, Luana
- Venue
- Current Opinion in Psychiatry
- Published
- 2011-03
- Volume
- 24
- Issue
- 2
- Pages
- 149-155
- ISSN
- 0951-7367 (ISSN-L)
- OpenAlex
- W2317572789
- Cited by
- 161
- References
- 52
- Citations by year
- 2026: 12 · 2025: 11 · 2024: 17 · 2023: 13 · 2022: 5 · 2021: 15 · 2020: 14 · 2019: 9 · 2018: 15 · 2017: 9 · 2016: 8 · 2015: 7 · 2014: 4 · 2013: 9 · 2012: 11
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Keywords
- expectations, placebo effect, nocebo effect, mental illness, symptom relief, clinical trial design, patient care, wellness
- MeSH terms
- Mental Disorders, Clinical Trials as Topic, Humans, Placebos, Treatment Outcome, Outcome Assessment, Health Care
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