Cited by 107Cannabis and Cannabinoid ResearchPain Management and Placebo EffectPsychedelics and Drug Studies

Effectiveness of a marijuana expectancy manipulation: Piloting the balanced-placebo design for marijuana

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Metrik, Jane, Rohsenow, Damaris J., Monti, Peter M., McGeary, John, Cook, Travis A. R., de Wit, Harriet, Haney, Margaret, Kahler, Christopher W.·2009·Experimental and Clinical Psychopharmacology

Abstract

Although alcohol and nicotine administration studies have demonstrated that manipulating subjects' expectancies regarding drug content affects drug response, research with marijuana has not adequately studied drug expectancy effects. The present pilot study was the first to evaluate the credibility and effect of expectancy manipulation on subjective measures and smoking patterns using a marijuana administration balanced-placebo design (BPD). In a 2 x 2 instructional set (told delta-9-tetrahydrocannabinol [THC] vs. told no THC) by drug (smoked marijuana with 2.8% THC vs. placebo) between-subjects design, the authors examined the effect of marijuana expectancy manipulation and the pharmacologic effect on affective and physiologic measures, cigarette ratings, and smoking behavior with 20 marijuana smokers (mean age = 20 years; 25% female). Large main effects of expectancy were found on ratings of cigarette potency, strength, taste, smell, and satisfaction, and observed smoking behavior. Pharmacologic effects were particularly evident for self-reported physical reactions to marijuana and cigarette potency and satisfaction ratings. This study demonstrated the feasibility of the BPD research with marijuana and yielded promising results for future studies examining the independent and combined effects of marijuana pharmacology and expectancies.

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Crossref · 10.1037/a0016502

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  • Findings of balanced placebo designs that included other interventions and drug effects have been mixed regarding whether effects were additive or interactive.

    “Still, findings of balanced placebo designs that included other interventions and drug effects have been mixed regarding whether effects were additive or interactive (Boussageon et al., 2022; Metrik et al., 2009).”

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Research works printed but not linked: 2

  1. Alioto JT 1974 The effects of the expectancy of receiving either marijuana or alcohol on subsequent aggression in provoked high and low users of these drugs Unpublished doctoral dissertation University of Wisconsin
  2. Marlatt GA Rohsenow DJ Mello NK 1980 Cognitive processes in alcohol use: Expectancy and the balanced placebo design Advances in substance abuse: Behavioral and biological research 159 199 Greenwich, CT JAI Press

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Authors
Metrik, J., Rohsenow, D. J., Monti, P. M., McGeary, J., Cook, T. A. R., de Wit, H., Haney, M., & Kahler, C. W.
Affiliations
  • Brown University (US)
  • New York State Psychiatric Institute (US)
Venue
Experimental and Clinical Psychopharmacology
Published
2009-08
Volume
17
Issue
4
Pages
217-225
ISSN
  • 1064-1297 (ISSN-L)
  • 1936-2293
OpenAlex
W2054068506
Cited by
107
References
61
Citations by year
2026: 3 · 2025: 4 · 2024: 8 · 2023: 5 · 2022: 7 · 2021: 5 · 2020: 12 · 2019: 10 · 2018: 1 · 2017: 9 · 2016: 6 · 2015: 3 · 2014: 10 · 2013: 8 · 2012: 9
FWCI
3.85
Type
journal article
Language
en
Open access
Locations
  • Experimental and Clinical Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Brown University
  • National Institute on Drug Abuse (R01 DA021403)
  • US Department of Veterans Affairs
Topics
  • Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
  • Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
Keywords
cannabis, delta-9-tetrahydrocannabinol, smoking behavior, smoking satisfaction
MeSH terms
Adolescent, Adult, Affect, Attitude, Female, Humans, Male, Marijuana Smoking, Pilot Projects, Placebos, Dronabinol

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