Cited by 137Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

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Is Alzheimer’s a disease of the white matter?

Sachdev, Perminder S., Zhuang, Lin, Braidy, Nady, Wen, Wei·2013·Current Opinion in Psychiatry

DOI 10.1097/yco.0b013e32835ed6e8

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Abstract

PURPOSE OF REVIEW: Alzheimer's disease has long been primarily considered a disease of gray matter. However, convergent evidence has suggested that white matter abnormalities are also important components of Alzheimer's disease. We undertook a review of the recent findings of Alzheimer's disease related white matter aberrations identified in patients with Alzheimer's disease and using in-vitro and in-vivo models, and discuss the potential causes of white matter damage in Alzheimer's disease. In doing so, we aim to provide a renewed insight into white matter changes in Alzheimer's disease and related dementias. RECENT FINDINGS: Neuroimaging studies have found that patients with preclinical Alzheimer's disease have widespread white matter abnormalities at a stage similar to those reported in Alzheimer's disease, whereas gray matter structures were relatively intact. In addition, demyelination of the white matter is reported to occur prior to the presence of amyloid-β plaques and neurofibrillary tangles in the presymptomatic stages of Alzheimer's disease. Furthermore, in a mouse model of Alzheimer's disease, axonal disease due to impaired axonal transport was shown to precede and drive downstream production and aggregation of amyloid β peptides. SUMMARY: White matter abnormalities not only represent an early neuropathological event in Alzheimer's disease but may also play an important role in the pathogenesis and diagnosis of Alzheimer's disease.

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Authors: Sachdev, P. S., Zhuang, L., Braidy, N., & Wen, W.
Affiliations: UNSW Sydney (AU)
Corresponding author: Sachdev, Perminder S.
ORCID: Sachdev, Perminder S.
Zhuang, Lin
Braidy, Nady
Wen, Wei
Venue: Current Opinion in Psychiatry
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2013-05
Volume: 26
Issue: 3
Pages: 244-251
ISSN: 0951-7367 (ISSN-L)
DOI: 10.1097/yco.0b013e32835ed6e8
OpenAlex: W2086015438
Cited by: 137
References: 101
Citations by year: 2026: 7 · 2025: 5 · 2024: 14 · 2023: 16 · 2022: 12 · 2021: 16 · 2020: 11 · 2019: 9 · 2018: 13 · 2017: 9 · 2016: 10 · 2015: 5 · 2014: 8 · 2013: 2
FWCI: 0.92
Type: journal article
Language: en
Open access: closed
Locations: Current Opinion in Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: National Health and Medical Research Council
National Medical Research Council
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: Alzheimer's disease, white matter abnormalities, demyelination, amyloid-beta, preclinical Alzheimer's disease, neurofibrillary tangles, mouse models of Alzheimer's disease, dementia pathogenesis, early diagnosis
MeSH terms: Alzheimer Disease, Animals, Disease Models, Animal, Humans, Mice, Leukoencephalopathies, Neuroimaging

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