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Olanzapine therapy in anorexia nervosa: psychobiological effects
Open accessAbstract
Dopamine impairments occur in anorexia nervosa. The aim of this study was to see whether treatment with the atypical dopamine antagonist antipsychotic olanzapine improves the disorder. Thirty anorexics, 18 restricted and 12 bingeing-purging, underwent a 3-month course of cognitive behavioral therapy, plus at random and double-blinded oral olanzapine (2.5 mg for 1 month, 5 mg for 2 months) in half and oral placebo in the other half of them. BMI, psychopathological aspects (eating disorder inventory, Hamilton Rating Scale, Buss-Durkee Rating Scale, Yale Brown Cornell for Eating Disorders Rating Scale, temperament-character inventory), and homovanillic acid blood concentrations for dopamine secretion, were monitored at baseline and then monthly during the trial. At the end of the trial BMI, total eating disorder inventory, total Yale Brown Cornell for Eating Disorders Rating Scale, Buss-Durkee Rating Scale, Hamilton Rating Scale scores and in olanzapine-treated patients the subitems of eating disorder inventory ineffectiveness and maturity fear, of Buss-Durkee Rating Scale direct aggressiveness, of temperament-characteristic inventory persistence had improved significantly. When stratified for anorexia nervosa subtype, BMI changes were significant among anorexia nervosa bingeing-purging patient, 'depression' (Hamilton Rating Scale) and 'direct aggressiveness' (Buss-Durkee Rating Scale) among anorexia nervosa bingeing-purging patients, 'persistence' (temprerament-characteristic inventory), among anorexics restricted patients, with a trend toward significance for obsessivity-compulsivity (Yale Brown Cornell for Eating Disorders Rating Scale). homovanilic acid blood levels increased significantly in the cognitive behavioral therapy+olanzapine group. No correlations were observed between homovanilic acid concentrations and psychopathological parameters. The pharmacological treatment can significantly improve specific aspects of anorexia nervosa.
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Metadata
- Authors
- Brambilla, F., Garcia, C. S., Fassino, S., Daga, G. A., Favaro, A., Santonastaso, P., Ramaciotti, C., Bondi, E., Mellado, C., Borriello, R., & Monteleone, P.
- Affiliations
- University of Pisa (IT)
- Venue
- International Clinical Psychopharmacology
- Published
- 2007-07
- Volume
- 22
- Issue
- 4
- Pages
- 197-204
- ISSN
- 0268-1315 (ISSN-L)
- OpenAlex
- W2045510386
- Cited by
- 156
- References
- 78
- Citations by year
- 2026: 3 · 2025: 14 · 2024: 8 · 2023: 9 · 2022: 2 · 2021: 4 · 2020: 7 · 2019: 10 · 2018: 6 · 2017: 5 · 2016: 1 · 2015: 12 · 2014: 7 · 2013: 9 · 2012: 10
- FWCI
- 10.51
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- other-oa
- Locations
- International Clinical Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion, other-oa)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Nursing › Nutrition and Dietetics › Nutrition, Health and Food Behavior
- Keywords
- anorexia nervosa, olanzapine, atypical antipsychotics, dopamine antagonists, homovanillic acid, cognitive behavioral therapy, eating disorder symptoms, temperament, aggression, depression, obsessive-compulsive symptoms
- MeSH terms
- Olanzapine, Adult, Anorexia Nervosa, Benzodiazepines, Combined Modality Therapy, Double-Blind Method, Female, Homovanillic Acid, Humans, Antipsychotic Agents, Cognitive Behavioral Therapy, Dopamine Antagonists
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