The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
Bio-metals imaging and speciation in cells using proton and synchrotron radiation X-ray microspectroscopy
Open accessAbstract
The direct detection of biologically relevant metals in single cells and of their speciation is a challenging task that requires sophisticated analytical developments. The aim of this article is to present the recent achievements in the field of cellular chemical element imaging, and direct speciation analysis, using proton and synchrotron radiation X-ray micro- and nano-analysis. The recent improvements in focusing optics for MeV-accelerated particles and keV X-rays allow application to chemical element analysis in subcellular compartments. The imaging and quantification of trace elements in single cells can be obtained using particle-induced X-ray emission (PIXE). The combination of PIXE with backscattering spectrometry and scanning transmission ion microscopy provides a high accuracy in elemental quantification of cellular organelles. On the other hand, synchrotron radiation X-ray fluorescence provides chemical element imaging with less than 100 nm spatial resolution. Moreover, synchrotron radiation offers the unique capability of spatially resolved chemical speciation using micro-X-ray absorption spectroscopy. The potential of these methods in biomedical investigations will be illustrated with examples of application in the fields of cellular toxicology, and pharmacology, bio-metals and metal-based nano-particles.
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“The combination of X-ray imaging with X-ray Fluorescence microscopy (μ-XRF) allows monitoring of the distribution of elements in tissue samples without artefacts2728, as demonstrated in our recent study of asbestos bodies29.”
From The interaction of asbestos and iron in lung tissue revealed by synchrotron-based scanning X-ray microscopy (2013) · cites this paper as [27]
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Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctr1 in yeast and mammals
Ishida, S., Lee, J., Thiele, D. J., & Herskowitz, I. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.162491399 · Cited by 927
Concepts of Backscattering Spectrometry
Chu, W., Mayer, J. W., & Nicolet, M. (1978) · Elsevier eBooks · doi:10.1016/b978-0-12-173850-1.50008-9 · Cited by 792
X-ray analysis: Elemental trace analysis at the 10−12 g level
Johansson, T., Akselsson, R., & JOHANSSON, S. A. E. (1970) · Nuclear Instruments and Methods · doi:10.1016/0029-554x(70)90751-2 · Cited by 481
Yang, L., McRae, R. L., Henary, M., Patel, R., Lai, B. C. H., Vogt, S., & Fahrni, C. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406547102 · Cited by 387
Resistance mechanisms associated with altered intracellular distribution of anticancer agents
Larsen, A. K., Escargueil, A. E., & Składanowski, A. (2000) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(99)00073-x · Cited by 378
c-Type Cytochrome-Dependent Formation of U(IV) Nanoparticles by Shewanella oneidensis
Marshall, M. J., Beliaev, A. S., Dohnalkova, A. C., Kennedy, D. W., Shi, L., Wang, Z.-M., Boyanov, M. I., Lai, B. C. H., Kemner, K., McLean, J. S., et al. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040268 · Cited by 365
Biology of TiO2–oligonucleotide nanocomposites
Paunesku, T., Rajh, T., Wiederrecht, G. P., Maser, J. M., Vogt, S., Stojićević, N., Protić, M., Lai, B. C. H., Oryhon, J., Thurnauer, M. C., et al. (2003) · Nature Materials · doi:10.1038/nmat875 · Cited by 298
Fahrni, C. J. (2007) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2007.02.039 · Cited by 297
Twining, B. S., Baines, S. B., Fisher, N. S., Maser, J. M., Vogt, S., Jacobsen, C. J., Tovar‐Sánchez, A., & Sañudo‐Wilhelmy, S. A. (2003) · Analytical Chemistry · doi:10.1021/ac034227z · Cited by 250
Imaging and speciation of trace elements in biological environment
Łobiński, R., Moulin, C., & Ortega, R. B. (2006) · Biochimie · doi:10.1016/j.biochi.2006.10.003 · Cited by 240
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In Situ Imaging of Metals in Cells and Tissues
McRae, R. L., Bagchi, P., Sumalekshmy, S., & Fahrni, C. J. (2009) · Chemical Reviews · doi:10.1021/cr900223a · Cited by 581
Physicochemical Properties of Cells and Their Effects on Intrinsically Disordered Proteins (IDPs)
Theillet, F., Binolfi, A., Frembgen-Kesner, T., Hingorani, K. S., Sarkar, M., Kyne, C., Li, C., Crowley, P. B., Gierasch, L. M., Pielak, G. J., et al. (2014) · Chemical Reviews · doi:10.1021/cr400695p · Cited by 521
The Bionanoprobe: hard X-ray fluorescence nanoprobe with cryogenic capabilities
Chen, S., Deng, J., Yuan, Y., Flachenecker, C., Mak, R., Hornberger, B., Jin, Q., Shu, D., Lai, B. C. H., Maser, J. M., et al. (2013) · Journal of Synchrotron Radiation · doi:10.1107/s1600577513029676 · Cited by 179
Ackerman, C. M., Lee, S., & Chang, C. J. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.6b04631 · Cited by 179
Advances in functional X-ray imaging techniques and contrast agents
Chen, H., Rogalski, M. M., & Anker, J. N. (2012) · Physical Chemistry Chemical Physics · doi:10.1039/c2cp41858d · Cited by 178
Metadata
- Authors
- Ortega, R., Devès, G., & Carmona, A.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Venue
- Journal of The Royal Society Interface
- Publisher
- The Royal Society
- Published
- 2009-07-15
- Volume
- 6
- Issue
- suppl_5
- Pages
- S649-58
- ISSN
- 1742-5662 (ISSN-L)
- 1742-5689
- PMC
- PMC2843977
- OpenAlex
- W2167807896
- Cited by
- 150
- References
- 62
- Citations by year
- 2025: 5 · 2024: 2 · 2023: 7 · 2022: 5 · 2021: 3 · 2020: 5 · 2019: 13 · 2018: 6 · 2017: 7 · 2016: 17 · 2015: 9 · 2014: 18 · 2013: 6 · 2012: 23
- FWCI
- 2.20
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of The Royal Society Interface (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Oskar-Bordeaux (Universite de Bordeaux) (submittedVersion)
- Topics
- Physical Sciences › Physics and Astronomy › Radiation › X-ray Spectroscopy and Fluorescence Analysis
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Electron and X-Ray Spectroscopy Techniques
- Physical Sciences › Physics and Astronomy › Radiation › Advanced X-ray Imaging Techniques
- Keywords
- metal speciation, PIXE, backscattering spectrometry, scanning transmission ion microscopy, synchrotron X-ray fluorescence, micro-X-ray absorption spectroscopy, metal-based nanoparticles
- MeSH terms
- Biopolymers, Metals, Protons, Spectrometry, X-Ray Emission, Synchrotrons
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