The DOI matches its Crossref record; 154 of the 154 references it cites were found in a registry or an index.
Inflammation in intervertebral disc degeneration and regeneration
Open accessAbstract
Intervertebral disc (IVD) degeneration is one of the major causes of low back pain, a problem with a heavy economic burden, which has been increasing in prevalence as populations age. Deeper knowledge of the complex spatial and temporal orchestration of cellular interactions and extracellular matrix remodelling is critical to improve current IVD therapies, which have so far proved unsatisfactory. Inflammation has been correlated with degenerative disc disease but its role in discogenic pain and hernia regression remains controversial. The inflammatory response may be involved in the onset of disease, but it is also crucial in maintaining tissue homeostasis. Furthermore, if properly balanced it may contribute to tissue repair/regeneration as has already been demonstrated in other tissues. In this review, we focus on how inflammation has been associated with IVD degeneration by describing observational and in vitro studies as well as in vivo animal models. Finally, we provide an overview of IVD regenerative therapies that target key inflammatory players.
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Cites
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Cited by
Lyu, F.-J., Cui, H., Pan, H., MC Cheung, K., Cao, X., Iatridis, J. C., & Zheng, Z. (2021) · Bone Research · doi:10.1038/s41413-020-00125-x · Cited by 474
Intervertebral disc degeneration: A focus on obesity and type 2 diabetes
Cannata, F., Vadalà, G., Ambrosio, L., Fallucca, S., Napoli, N., Papalia, R., Pozzilli, P., & Denaro, V. (2020) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3224 · Cited by 144
Adiponectin downregulates TNF-α expression in degenerated intervertebral discs
Yuan, B., Huang, L., Yan, M., Zhang, S., Zhang, Y., Jin, B., Ma, Y., & Luo, Z. (2018) · Spine · doi:10.1097/brs.0000000000002364 · Cited by 30
Metadata
- Authors
- Molinos, M., Almeida, C. R., Caldeira, J., Cunha, C., Gonçalves, R. M., & Barbosa, M. A.
- Venue
- Journal of The Royal Society Interface
- Publisher
- The Royal Society
- Published
- 2015-03
- Volume
- 12
- Issue
- 104
- Pages
- 20141191
- ISSN
- 1742-5662 (ISSN-L)
- 1742-5689
- OpenAlex
- W2123821833
- Cited by
- 454
- References
- 154
- FWCI
- 18.58
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Molinos, M., Almeida, C. R., Caldeira, J., Cunha, C., Gonçalves, R. M., & Barbosa, M. A. (2015). Inflammation in intervertebral disc degeneration and regeneration. Journal of The Royal Society Interface. https://doi.org/10.1098/rsif.2014.1191
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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