The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Immune system stimulation by the native gut microbiota of honey bees
Open accessAbstract
Gut microbial communities can greatly affect host health by modulating the host's immune system. For many important insects, however, the relationship between the gut microbiota and immune function remains poorly understood. Here, we test whether the gut microbial symbionts of the honey bee can induce expression of antimicrobial peptides (AMPs), a crucial component of insect innate immunity. We find that bees up-regulate gene expression of the AMPs apidaecin and hymenoptaecin in gut tissue when the microbiota is present. Using targeted proteomics, we detected apidaecin in both the gut lumen and the haemolymph; higher apidaecin concentrations were found in bees harbouring the normal gut microbiota than in bees lacking gut microbiota. In in vitro assays, cultured strains of the microbiota showed variable susceptibility to honey bee AMPs, although many seem to possess elevated resistance compared to Escherichia coli . In some trials, colonization by normal gut symbionts resulted in improved survivorship following injection with E. coli . Our results show that the native, non-pathogenic gut flora induces immune responses in the bee host. Such responses might be a host mechanism to regulate the microbiota, and could potentially benefit host health by priming the immune system against future pathogenic infections.
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Cites
Interactions Between the Microbiota and the Immune System
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Mechanisms of Antimicrobial Peptide Action and Resistance
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The gut microbiota of insects – diversity in structure and function
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Self-citationImmune pathways and defence mechanisms in honey bees Apis mellifera
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Gut microbial communities of social bees
Kwong, W. K., & Moran, N. A. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.43 · Cited by 971
Self-citationSocially transmitted gut microbiota protect bumble bees against an intestinal parasite
Koch, H., & Schmid-Hempel, P. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1110474108 · Cited by 824
MARTINSON, V. G., DANFORTH, B. N., MINCKLEY, R. L., RUEPPELL, O., TINGEK, S., & MORAN, N. A. (2011) · Molecular Ecology · doi:10.1111/j.1365-294x.2010.04959.x · Cited by 579
Self-citationYang, X., & Cox-Foster, D. L. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501860102 · Cited by 567
Routes of Acquisition of the Gut Microbiota of the Honey Bee Apis mellifera
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Self-citationMorphological and Molecular Characterization of Adult Midgut Compartmentalization in Drosophila
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Cited by
Glyphosate perturbs the gut microbiota of honey bees
Motta, E. V. S., Raymann, K., & Moran, N. A. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1803880115 · Cited by 702
Self-citationThe role of the gut microbiome in health and disease of adult honey bee workers
Raymann, K., & Moran, N. A. (2018) · Current Opinion in Insect Science · doi:10.1016/j.cois.2018.02.012 · Cited by 477
Self-citationHoney bees as models for gut microbiota research
Zheng, H., Steele, M. I., Leonard, S. P., Motta, E. V. S., & Moran, N. A. (2018) · Lab Animal · doi:10.1038/s41684-018-0173-x · Cited by 334
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Metadata
- Authors
- Kwong, W. K., Mancenido, A. L., & Moran, N. A.
- Venue
- Royal Society Open Science
- Publisher
- The Royal Society
- Published
- 2017-02
- Volume
- 4
- Issue
- 2
- Pages
- 170003
- ISSN
- 2054-5703 (ISSN-L)
- OpenAlex
- W2587173691
- Cited by
- 425
- References
- 36
- FWCI
- 12.35
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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