The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
Morphological and Molecular Characterization of Adult Midgut Compartmentalization in Drosophila
Open accessAbstract
Although the gut is a central organ of Eumetazoans and is essential for organismal health, our understanding of its morphological and molecular determinants remains rudimentary. Here, we provide a comprehensive atlas of Drosophila adult midgut. Specifically, we uncover a fine-grained regional organization consisting of 14 subregions with distinct morphological, histological, and genetic properties. We also show that Drosophila intestinal regionalization is defined after adult emergence, remains stable throughout life, and reestablishes following acute tissue damage. Additionally, we show that this midgut compartmentalization is achieved through the interplay between pan-midgut and regionalized transcription factors, in concert with spatial activities of morphogens. Interestingly, disruption of the midgut compartmentalization leads to a loss of intestinal homeostasis characterized by an increase in stem cell proliferation and aberrant immune responses. Our integrative analysis of Drosophila midgut compartmentalization provides insights into the conserved mechanisms underlying intestinal regionalization in metazoans.
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The Host Defense of Drosophila melanogaster
Lemaitre, B., & Hoffmann, J. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141615 · Cited by 3,324
Self-citationUsing FlyAtlas to identify better Drosophila melanogaster models of human disease
Chintapalli, V. R., Wang, J., & Dow, J. A. T. (2007) · Nature Genetics · doi:10.1038/ng2049 · Cited by 1,472
Evidence that stem cells reside in the adult Drosophila midgut epithelium
Micchelli, C. A., & Perrimon, N. (2006) · Nature · doi:10.1038/nature04371 · Cited by 1,131
Insect digestive enzymes: properties, compartmentalization and function
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Cytokine/Jak/Stat Signaling Mediates Regeneration and Homeostasis in the Drosophila Midgut
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Self-citationInnate Immune Homeostasis by the Homeobox Gene Caudal and Commensal-Gut Mutualism in Drosophila
Ryu, J.-H., Kim, S.-H., Lee, H.-Y., Bai, J. Y., Nam, Y.-D., Bae, J.-W., Lee, D. G., Shin, S. C., Ha, E.-M., & Lee, W.-J. (2008) · Science · doi:10.1126/science.1149357 · Cited by 829
A Direct Role for Dual Oxidase in Drosophila Gut Immunity
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Self-citationSelf-Renewal and Cancer of the Gut: Two Sides of a Coin
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Anatomy and Physiology of the Digestive Tract of Drosophila melanogaster
Miguel-Aliaga, I., Jasper, H., & Lemaitre, B. (2018) · Genetics · doi:10.1534/genetics.118.300224 · Cited by 491
Mechanical regulation of stem-cell differentiation by the stretch-activated Piezo channel
He, L., Si, G., Huang, J., Samuel, A. D. T., & Perrimon, N. (2018) · Nature · doi:10.1038/nature25744 · Cited by 348
Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism
Schell, J. C., Wisidagama, D. R., Bensard, C., Zhao, H., Wei, P., Tanner, J., Flores, A., Mohlman, J., Sorensen, L. K., Earl, C. S., et al. (2017) · Nature Cell Biology · doi:10.1038/ncb3593 · Cited by 322
Dutta, D., Dobson, A. J., Houtz, P. L., Gläßer, C., Revah, J., Korzelius, J., Patel, P. H., Edgar, B. A., & Buchon, N. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.06.009 · Cited by 254
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Metadata
- Authors
- Buchon, N., Osman, D., David, F. P. A., Yu Fang, H., Boquete, J.-P., Deplancke, B., & Lemaitre, B.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2013-05
- Volume
- 3
- Issue
- 5
- Pages
- 1725-1738
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W2153718995
- Cited by
- 513
- References
- 62
- FWCI
- 14.93
- Type
- journal article
- Language
- en
- Open access
- gold
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