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Curcumin improves glycolipid metabolism through regulating peroxisome proliferator activated receptor γ signalling pathway in high-fat diet-induced obese mice and 3T3-L1 adipocytes
Abstract
Curcumin is an active component derived from Curcuma longa L. which is a traditional Chinese medicine that is widely used for treating metabolic diseases through regulating different molecular pathways. Here, in this study, we aimed to comprehensively investigate the effects of curcumin on glycolipid metabolism in vivo and in vitro and then determine the underlying mechanism. Male C57BL/6 J obese mice and 3T3-L1 adipocytes were used for in vivo and in vitro study, respectively. Our results demonstrated that treatment with curcumin for eight weeks decreased body weight, fat mass and serum lipid profiles. Meanwhile, it lowered fasting blood glucose and increased the insulin sensitivity in high-fat diet-induced obese mice. In addition, curcumin stimulated lipolysis and improved glycolipid metabolism through upregulating the expressions of adipose triglyceride lipase and hormone-sensitive lipase, peroxisome proliferator activated receptor γ/α (PPARγ/α) and CCAAT/enhancer binding proteinα (C/EBPα) in adipose tissue of the mice. In differentiated 3T3-L1 cells, curcumin reduced glycerol release and increased glucose uptake via upregulating PPARγ and C/EBPα. We concluded that curcumin has the potential to improve glycolipid metabolism disorders caused by obesity through regulating PPARγ signalling pathway.
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“Curcumin, the main curcuminoid present in turmeric (Curcuma longa L.), has demonstrated multiple biological activities, including anti-inflammatory, anticancer, and antioxidant properties [11].”
From Curcumin Supplementation Improves Gastrointestinal Symptoms in Women with Severe Obesity: A Double-Blind, Randomized, Placebo-Controlled Trial—A Pilot Study (2025) · cites this paper as [11]
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Kakkar, A. K., & Dahiya, N. (2015) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2015.01.005 · Cited by 113
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Cited by
Kattah, F. M., Figueiredo, N., Bezerra, K. K., Oliveira, E. S., Melo, C. C. D., Lima, G. B., Cavalcante, J. P. R., Benetti, B. B. D. C., Lima, G. C., Mota, J. F., et al. (2025) · Nutrients · doi:10.3390/nu17132064 · Cited by 6
Metadata
- Authors
- Pan, Y., Zhao, D., Yu, N., An, T., Miao, J., Mo, F., Gu, Y., Zhang, D., Gao, S., & Jiang, G.
- Affiliations
- Traditional Chinese Medicine School, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China
- Diabetes Research Center, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China
- ORCID
- Pan, Yanyun
- Venue
- Royal Society Open Science
- Publisher
- The Royal Society
- Published
- 2017-11
- Volume
- 4
- Issue
- 11
- Pages
- 170917
- ISSN
- 2054-5703
- Cited by
- 51
- References
- 1
- Language
- en
- Licence
- royalsociety.org/journals/ethics-policies/data-sharing-mining/ (tdm)
- Funders
- National Natural Science Foundation of China (NSFC81274041, NSFC81503540)
- The Beijing University of Chinese Medicine Xin-Ao Award Fund (1000062720062/008/005)
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- Pan, Y., Zhao, D., Yu, N., An, T., Miao, J., Mo, F., Gu, Y., Zhang, D., Gao, S., & Jiang, G. (2017). Curcumin improves glycolipid metabolism through regulating peroxisome proliferator activated receptor γ signalling pathway in high-fat diet-induced obese mice and 3T3-L1 adipocytes. Royal Society Open Science. https://doi.org/10.1098/rsos.170917
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
