The Leeuwenhoek Lecture, 1971 - Tumour viruses and the sociology of fibroblasts
Abstract
Coincident with the more spectacular developments in biology of the last two decades there has quietly emerged a new technology with far-reaching potential, namely the growth and manipulation of animal and plant cells in culture. It has naturally led to an emphasis on homogeneous populations of isolated cells as a step towards simplifying the formidable complexities of even the simplest multicellular tissues. In this way cell culture tends to make microbiologists of us all, followers in the footsteps of Anthony van Leeuwenhoek himself. The microbiological approach is highly productive in the present limited state of knowledge, but will be even more productive if the special properties of metazoan as opposed to protozoan cells can be preserved and analysed. Metazoan cells, in particular, are highly social, and many properties, which may be missed in cultures, are dependent on interactions between the cells. These may be either long range, mediated for example by hormones circulating widely in body fluids, but with high specificity for certain target cells, or short range, at nerve synapses for example, or in growth following wounds.
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Suboptimal conditions such as high cell density or insufficient serum can drive cells into quiescence.
“Subsequent studies demonstrated that sub-optimal conditions such as high cell density7 or serum insufficiency8 could drive cells into this quiescent state.”
From Molecular regulation of stem cell quiescence (2013) · cites this paper as [7]
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Sir Michael George Parke Stoker. 4 July 1918—13 August 2013
Weiss, R. A. (2024) · Biographical Memoirs of Fellows of the Royal Society · doi:10.1098/rsbm.2023.0051
- Authors
- Stoker, M. G. P.
- Affiliations
- Imperial Cancer Research Fund Laboratories
- Corresponding author
- Stoker, Michael George Parke
- Venue
- Proceedings of the Royal Society of London. Series B. Biological Sciences
- Publisher
- The Royal Society
- Published
- 1972-04-18
- Volume
- 181
- Issue
- 1062
- Pages
- 1-17
- ISSN
- 0080-4649 (ISSN-L)
- 2053-9193
- OpenAlex
- W2074206348
- Cited by
- 41
- References
- 1
- Citations by year
- 2024: 1 · 2022: 1 · 2018: 1 · 2017: 2 · 2013: 2 · 2012: 1
- FWCI
- 3.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Proceedings of the Royal Society B Biological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Keywords
- oncogenic viruses, fibroblasts, cell culture, cell-cell interactions, metazoan cells, intercellular communication, wound healing, hormone signaling
- MeSH terms
- Cell Line, Cell Transformation, Neoplastic, Cells, Cultured, Contact Inhibition, Culture Media, Fibroblasts, Mutation, Oncogenic Viruses, Phenotype
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