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Cited by 165Neurobiology of Language and BilingualismReading and Literacy DevelopmentNeural and Behavioral Psychology Studies

The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

Investigating a network model of word generation with positron emission tomography

Karl John Friston, Chris Frith, Peter Francis Liddle, Richard S. J. Frackowiak·1991·Proceedings of the Royal Society of London. Series B: Biological Sciences
DOI 10.1098/rspb.1991.0057
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Abstract

By using positron emission tomography (PET) we examined the biological validity of a network model describing changes in cerebral activity associated with intrinsic and extrinsic word generation. The production of words not specified by an extrinsic stimulus constitutes willed or intrinsic generation. Perceiving a heard word is an example of extrinsic generation. The model incorporates three neuronal systems: a pool that stores word representations in a distributed fashion, an afferent system conveying sensory input to the pool and a modulating system that alters the responsivity of neurons in the pool. Simulations based on the model suggested that intrinsic generation would be associated with low activity in the pool, consequent on reduced modulation, and extrinsic generation with high activity. We measured cerebral activity with PET during intrinsic (verbal fluency) and extrinsic (responding to heard words) word generation and found this pattern of changes in the left superior temporal region. We were able to designate this region the site of the distributed word store and implicate the left dorsolateral prefrontal cortex (DLPFC) as the source of modulation. The relation between the superior temporal gyrus and DLPFC was shown by examining the correlation between the two regions in terms of cerebral activity. We conclude that the left DLPFC is responsible for modulating the responsivity of a neural system in the superior temporal gyrus and is the probable mediator of changes in attentional and intentional states that underlies the intrinsic generation of words.

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Research works printed but not linked: 3

  1. Glowinski J., 1984, The mesocortico-prefrontal dopaminergic neruons, TINS, 7, 415
  2. Talairach J. & Tournoux P. 1988 A co-planar stereotactic atlas of a human brain. Stuttgart: Thieme.
  3. Warkentin S., 1989, Absence of frontal lobe activation in schizophrenia, J. Cereb. Blood. Flow Metab., 9, S354

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Metadata

Authors
Friston, K. J., Frith, C., Liddle, P. F., & Frackowiak, R. S. J.
Affiliations
Hammersmith Hospital (GB)
ORCID
Venue
Proceedings of the Royal Society of London. Series B: Biological Sciences
Publisher
The Royal Society
Published
1991-05-22
Volume
244
Issue
1310
Pages
101-106
ISSN
  • 0080-4649 (ISSN-L)
  • 0962-8452
  • 1471-2954
DOI
10.1098/rspb.1991.0057
OpenAlex
W1972604089
Cited by
165
References
13
Citations by year
2026: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2018: 2 · 2017: 3 · 2014: 3 · 2013: 2 · 2012: 3
FWCI
4.39
Type
journal article
Language
en
Open access
closed
Locations
  • Proceedings of the Royal Society B Biological Sciences (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Funders
Wellcome Trust
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
  • Social Sciences › Psychology › Developmental and Educational Psychology › Reading and Literacy Development
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
word production, network models, verbal fluency, superior temporal gyrus, dorsolateral prefrontal cortex, neuromodulation, brain activity, attention, intentionality, spoken word recognition
MeSH terms
Animals, Brain, Humans, Models, Neurological, Models, Psychological, Nerve Net, Speech, Speech Perception, Tomography, Emission-Computed

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