Cited by 656Neurobiology of Language and BilingualismReading and Literacy DevelopmentNeural and Behavioral Psychology Studies

A PET study of word finding

Frith, C.D., Friston, K.J., Liddle, P.F., Frackowiak, R.S.J.·1991·Neuropsychologia

Abstract

We have used PET in conjunction with psychological activations to identify cortical areas involved in the intrinsic activation of word representations. In four normal subjects intrinsic generation of a word (verbal fluency) was associated with an increase in left dorsolateral prefrontal cortical activity (BA 46) and a bilateral decrease in activity in auditory and superior temporal cortices. Conversely, when subjects made lexical decisions about words that were heard, there was an increase in superior temporal activity with no change in area 46. We suggest that the superior temporal regions are the site of stored word representations and that inhibitory modulation of these areas by the left prefrontal cortex is the basis of intrinsic word generation.

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Crossref · 10.1016/0028-3932(91)90029-8

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  • A pruned and more myelinated adult brain could explain the faster reaction times and focal activation of the frontal cortex.

    “A pruned and more myelinated adult brain could explain the faster reaction times and focal activation of the frontal cortex, the area associated with generativity (Frith, Friston, Liddle, & Frackowiak, 1991) and the inhibitory response (Konishi et al., 1999).”
  • During verbal fluency, activation increases in the left dorsolateral prefrontal cortex but decreases in superior temporal cortices; during lexical decisions on heard words, activation increases in the superior temporal cortices with no change in prefrontal activation.

    “Frith et al. (1991) who demonstrated that when words were produced without stimuli (i.e. verbal fluency) activation increased in the left dorsolateral prefrontal cortex but decreased in superior temporal cortices, whereas, during lexical decisions on heard words, activation increased in the superior temporal cortices with no change in prefrontal activation.”

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Authors
Frith, C. D., Friston, K. J., Liddle, P. F., & Frackowiak, R. S. J.
Affiliations
Hammersmith Hospital (GB)
Corresponding author
Frith, C.D.
Venue
Neuropsychologia
Publisher
Elsevier BV
Published
1991-12
Volume
29
Issue
12
Pages
1137-1148
ISSN
0028-3932 (ISSN-L)
OpenAlex
W2007126717
Cited by
656
References
29
Citations by year
2025: 2 · 2024: 3 · 2023: 2 · 2022: 5 · 2021: 3 · 2020: 7 · 2019: 8 · 2018: 3 · 2017: 7 · 2016: 3 · 2015: 16 · 2014: 5 · 2013: 10 · 2012: 17
FWCI
9.13
Type
journal article
Language
en
Open access
closed
Locations
  • Neuropsychologia (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Funders
Wellcome Trust
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
  • Social Sciences › Psychology › Developmental and Educational Psychology › Reading and Literacy Development
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
word retrieval, word representation, verbal fluency, lexical decision, dorsolateral prefrontal cortex, area 46, superior temporal cortex, auditory cortex, cortical activation, inhibitory modulation, word production
MeSH terms
Adult, Attention, Brain Mapping, Dominance, Cerebral, Frontal Lobe, Humans, Male, Neural Inhibition, Phonetics, Mental Recall, Regional Blood Flow, Semantics, Speech Perception, Tomography, Emission-Computed, Verbal Behavior

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