A PET study of word finding
Abstract
We have used PET in conjunction with psychological activations to identify cortical areas involved in the intrinsic activation of word representations. In four normal subjects intrinsic generation of a word (verbal fluency) was associated with an increase in left dorsolateral prefrontal cortical activity (BA 46) and a bilateral decrease in activity in auditory and superior temporal cortices. Conversely, when subjects made lexical decisions about words that were heard, there was an increase in superior temporal activity with no change in area 46. We suggest that the superior temporal regions are the site of stored word representations and that inhibitory modulation of these areas by the left prefrontal cortex is the basis of intrinsic word generation.
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A pruned and more myelinated adult brain could explain the faster reaction times and focal activation of the frontal cortex.
“A pruned and more myelinated adult brain could explain the faster reaction times and focal activation of the frontal cortex, the area associated with generativity (Frith, Friston, Liddle, & Frackowiak, 1991) and the inhibitory response (Konishi et al., 1999).”
From Development of the adolescent brain: implications for executive function and social cognition (2006) · cites this paper as Frith et al., 1991
During verbal fluency, activation increases in the left dorsolateral prefrontal cortex but decreases in superior temporal cortices; during lexical decisions on heard words, activation increases in the superior temporal cortices with no change in prefrontal activation.
“Frith et al. (1991) who demonstrated that when words were produced without stimuli (i.e. verbal fluency) activation increased in the left dorsolateral prefrontal cortex but decreased in superior temporal cortices, whereas, during lexical decisions on heard words, activation increased in the superior temporal cortices with no change in prefrontal activation.”
From A review and synthesis of the first 20years of PET and fMRI studies of heard speech, spoken language and reading (2012) · cites this paper as Frith et al. (1991)
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- Authors
- Frith, C. D., Friston, K. J., Liddle, P. F., & Frackowiak, R. S. J.
- Affiliations
- Hammersmith Hospital (GB)
- Corresponding author
- Frith, C.D.
- Venue
- Neuropsychologia
- Publisher
- Elsevier BV
- Published
- 1991-12
- Volume
- 29
- Issue
- 12
- Pages
- 1137-1148
- ISSN
- 0028-3932 (ISSN-L)
- OpenAlex
- W2007126717
- Cited by
- 656
- References
- 29
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 2 · 2022: 5 · 2021: 3 · 2020: 7 · 2019: 8 · 2018: 3 · 2017: 7 · 2016: 3 · 2015: 16 · 2014: 5 · 2013: 10 · 2012: 17
- FWCI
- 9.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropsychologia (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Wellcome Trust
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Social Sciences › Psychology › Developmental and Educational Psychology › Reading and Literacy Development
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- word retrieval, word representation, verbal fluency, lexical decision, dorsolateral prefrontal cortex, area 46, superior temporal cortex, auditory cortex, cortical activation, inhibitory modulation, word production
- MeSH terms
- Adult, Attention, Brain Mapping, Dominance, Cerebral, Frontal Lobe, Humans, Male, Neural Inhibition, Phonetics, Mental Recall, Regional Blood Flow, Semantics, Speech Perception, Tomography, Emission-Computed, Verbal Behavior
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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