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Factors controlling cytoplasmic Ca2+ concentration
Abstract
The study of cellular Ca2+ exchange in smooth muscle has been severely limited by extensive extracellular Ga2+ binding. This problem was solved by using La3+ to trap Ca2+ inside the cells while displacing extracellular bound Ca2+. It was then shown that cytoplasmic Ca2+ could be raised by Ca2+ influx during high K+ depolarization, Na+ elimination and high pH. Ca2+ influx was inhibited by other multivalent cations, local anaesthetics and low pH. In the rabbit aortae norepinephrine and angiotensin increase cytoplasmic Ca2+ by release from intracellular membrane surfaces. In this same smooth muscle relaxation is brought about by intracellular Ca2+ binding. Evidence from vascular, uterine and intestinal smooth muscle demonstrates that the large transmembrane Ca2+ gradient depends on cellular [ATP] but not on the Na+ gradient. ATP depletion abolishes the Ca2+ gradient by increasing Ca2+ influx.
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Cited by
Blaustein, M. P. (1977) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1977.232.5.c165 · Cited by 1,310
Keppens, S., Vandenheede, J. R., & De Wulf, H. (1977) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(77)90327-0 · Cited by 305
Li, X., Yang, F., & Rubinsky, B. (2020) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2020.2965883 · Cited by 59
Metadata
- Authors
- van Breemen, C., Farinas, B. R., Casteels, R., Gerba, P., Wuytack, F., & Deth, R.
- Venue
- Philosophical Transactions of the Royal Society of London. B, Biological Sciences
- Publisher
- The Royal Society
- Published
- 1973-03-15
- Volume
- 265
- Issue
- 867
- Pages
- 57-71
- ISSN
- 0080-4622 (ISSN-L)
- 2054-0280
- OpenAlex
- W2153762697
- Cited by
- 261
- References
- 0
- FWCI
- 11.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Factors controlling cytoplasmic Ca2+ concentration. https://app.cochat.ai/papers/10.1098/rstb.1973.0009
- The paper
- van Breemen, C., Farinas, B. R., Casteels, R., Gerba, P., Wuytack, F., & Deth, R. (1973). Factors controlling cytoplasmic Ca2+ concentration. Philosophical Transactions of the Royal Society of London. B, Biological Sciences. https://doi.org/10.1098/rstb.1973.0009
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