On immunological memory
Open accessAbstract
Immunological memory may not represent a special characteristic of lymphocytes but simply reflect lowlevel responses driven by antigen that is re–encountered or persists within the host. T–cell memory is important to control persistent infections within the individual host and cannot be transmitted to offspring because of MHC polymorphism and MHC–restricted T–cell recognition. In contrast, antibody memory is transmissible from mother to offspring and may function essentially to protect offspring during the phase of physiological immuno–incompetence before, at and shortly after birth. This physiological immuno–incompetence is a result of MHC polymorphism and the dangers of the graft–versus–host and host–versus–graft reaction between mother and embryo, which necessitate immunosuppression of the mother and immuno–incompetence of the offspring. One may argue therefore that immunological memory of transmissible immunological experience is the basis on which MHC–restricted T–cell recognition could develop or coevolve.
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Antigen stimulation from infections results in immunological memory.
“Besides promoting recovery, such antigen stimulation results in immunological memory [41,42].”
From Evolution of the immune system in humans from infancy to old age (2015) · cites this paper as [42]
The low number of naive T cells versus T cells is a consequence of reduced thymic output from the involuted thymus.
“The low number of naive T cells versus T cells [41,42] is a consequence of the reduced thymic output from the involuted thymus.”
From Evolution of the immune system in humans from infancy to old age (2015) · cites this paper as [42]
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Zinkernagel, R. M. (2003)
Self-citation
- Authors
- Zinkernagel, R. M.
- Affiliations
- University Hospital Zurich (CH)
- Corresponding author
- Zinkernagel, Rolf M.
- Venue
- Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences
- Publisher
- The Royal Society
- Published
- 2000-03-29
- Volume
- 355
- Issue
- 1395
- Pages
- 369-371
- ISSN
- 0962-8436 (ISSN-L)
- 1471-2970
- PMC
- PMC1692736
- OpenAlex
- W3022405229
- Cited by
- 57
- References
- 24
- Citations by year
- 2026: 2 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 3 · 2015: 1 · 2014: 3 · 2013: 2 · 2012: 1
- FWCI
- 2.12
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Philosophical Transactions of the Royal Society B Biological Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- immunological memory, T cell memory, MHC polymorphism, persistent infection, maternal-fetal immune interaction, graft-versus-host disease, host-versus-graft reaction, immunosuppression
- MeSH terms
- Antibodies, Humans, Immunologic Memory, T-Lymphocytes, Cytotoxic
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