The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Rho GTPases: molecular switches that control the organization and dynamics of the actin cytoskeleton
Open accessAbstract
The actin cytoskeleton plays a fundamental role in all eukaryotic cells—it is a major determinant of cell morphology and polarity and the assembly and disassembly of filamentous actin structures provides a driving force for dynamic processes such as cell motility, phagocytosis, growth cone guidance and cytokinesis. The ability to reorganize actin filaments is a fundamental property of embryonic cells during development; the shape changes accompanying gastrulation and dorsal closure, for example, are dependent on the plasticity of the actin cytoskeleton, while the ability of cells or cell extensions, such as axons, to migrate within the developing embryo requires rapid and spatially organized changes to the actin cytoskeleton in response to the external environment. W ork in mammalian cells over the last decade has demonstrated the central role played by the highly conserved Rho family of small GTPases in signal transduction pathways that link plasma membrane receptors to the organization of the actin cytoskeleton.
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Cites
Rho GTPases and the Actin Cytoskeleton
Hall, A. (1998) · Science · doi:10.1126/science.279.5350.509 · Cited by 6,140
Self-citationRidley, A. J., & Hall, A. (1992) · Cell · doi:10.1016/0092-8674(92)90163-7 · Cited by 4,468
Self-citationNobes, C. D., & Hall, A. (1995) · Cell · doi:10.1016/0092-8674(95)90370-4 · Cited by 4,412
Self-citationCell Migration: A Physically Integrated Molecular Process
Lauffenburger, D. A., & Horwitz, A. F. (1996) · Cell · doi:10.1016/s0092-8674(00)81280-5 · Cited by 3,915
The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
Ridley, A. J., Paterson, H. F., Johnston, C. L., Diekmann, D., & Hall, A. (1992) · Cell · doi:10.1016/0092-8674(92)90164-8 · Cited by 3,652
Self-citationRho GTPases and signaling networks
Van Aelst, L., & D’Souza-Schorey, C. (1997) · Genes & Development · doi:10.1101/gad.11.18.2295 · Cited by 2,358
Minden, A., Lin, A., Claret, F.-X., Abo, A., & Karin, M. (1995) · Cell · doi:10.1016/s0092-8674(05)80019-4 · Cited by 1,478
Rho GTPases Control Polarity, Protrusion, and Adhesion during Cell Movement
Nobes, C. D., & Hall, A. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.144.6.1235 · Cited by 1,445
Self-citationThe small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway
Coso, O. A., Chiariello, M., Yu, J.-C., Teramoto, H., Crespo, P., Xu, N., Miki, T., & Silvio Gutkind, J. (1995) · Cell · doi:10.1016/s0092-8674(05)80018-2 · Cited by 1,397
The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF
Hill, C. S., Wynne, J., & Treisman, R. (1995) · Cell · doi:10.1016/s0092-8674(05)80020-0 · Cited by 1,269
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Regulation of cell polarity and protrusion formation by targeting RhoA for degradation
Wang, H.-R., Zhang, Y., Ozdamar, B., Ogunjimi, A. A., Alexandrova, E., Thomsen, G. H., & Wrana, J. L. (2003) · Science · doi:10.1126/science.1090772 · Cited by 551
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Co-regulation of cell adhesion by nanoscale RGD organization and mechanical stimulus
Koo, L. Y., Irvine, D. J., Mayes, A. M., Lauffenburger, D. A., & Griffith, L. G. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.7.1423 · Cited by 420
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Metadata
- Authors
- Hall, A., & Nobes, C. D.
- Venue
- Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences
- Publisher
- The Royal Society
- Published
- 2000-07-29
- Volume
- 355
- Issue
- 1399
- Pages
- 965-970
- ISSN
- 0962-8436 (ISSN-L)
- 1471-2970
- OpenAlex
- W1981228379
- Cited by
- 512
- References
- 27
- FWCI
- 9.80
- Type
- journal article
- Language
- en
- Open access
- green
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- Hall, A., & Nobes, C. D. (2000). Rho GTPases: molecular switches that control the organization and dynamics of the actin cytoskeleton. Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences. https://doi.org/10.1098/rstb.2000.0632
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
