The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.
Decomposing health: tolerance and resistance to parasites in animals
Open accessAbstract
Plant biologists have long recognized that host defence against parasites and pathogens can be divided into two conceptually different components: the ability to limit parasite burden (resistance) and the ability to limit the harm caused by a given burden (tolerance). Together these two components determine how well a host is protected against the effects of parasitism. This distinction is useful because it recognizes that hosts that are best at controlling parasite burdens are not necessarily the healthiest. Moreover, resistance and tolerance can be expected to have different effects on the epidemiology of infectious diseases and host–parasite coevolution. However, studies of defence in animals have to date focused on resistance, whereas the possibility of tolerance and its implications have been largely overlooked. The aim of our review is to (i) describe the statistical framework for analysis of tolerance developed in plant science and how this can be applied to animals, (ii) review evidence of genetic and environmental variation for tolerance in animals, and studies indicating which mechanisms could contribute to this variation, and (iii) outline avenues for future research on this topic.
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Cites
Superspreading and the effect of individual variation on disease emergence
Lloyd-Smith, J. O., Schreiber, S. J., Kopp, P. E., & Getz, W. M. (2005) · Nature · doi:10.1038/nature04153 · Cited by 2,514
Acquisition and Allocation of Resources: Their Influence on Variation in Life History Tactics
van Noordwijk, A. J., & de Jong, G. (1986) · The American Naturalist · doi:10.1086/284547 · Cited by 2,383
The ecology and evolution of plant tolerance to herbivory
Strauss, S. Y., & Agrawal, A. A. (1999) · Trends in Ecology & Evolution · doi:10.1016/s0169-5347(98)01576-6 · Cited by 1,626
Common West African HLA antigens are associated with protection from severe malaria
Hill, A. V. S., Allsopp, C. E. M., Kwiatkowski, D., Anstey, N. M., Twumasi, P., Rowe, P. A., Bennett, S., Brewster, D., McMichael, A. J., & Greenwood, B. M. (1991) · Nature · doi:10.1038/352595a0 · Cited by 1,552
The lek paradox and the capture of genetic variance by condition dependent traits
(1996) · Proceedings of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rspb.1996.0207 · Cited by 1,455
Variation in the TNF-α promoter region associated with susceptibility to cerebral malaria
McGuire, W., Hill, A. V. S., Allsopp, C. E. M., Greenwood, B. M., & Kwiatkowski, D. (1994) · Nature · doi:10.1038/371508a0 · Cited by 1,169
Direct and ecological costs of resistance to herbivory
Strauss, S. Y., Rudgers, J. A., Lau, J. A., & Irwin, R. E. (2002) · Trends in Ecology & Evolution · doi:10.1016/s0169-5347(02)02483-7 · Cited by 880
Biological and biomedical implications of the co-evolution of pathogens and their hosts
Woolhouse, M. E. J., Webster, J. P., Domingo, E., Charlesworth, B., & Levin, B. R. (2002) · Nature Genetics · doi:10.1038/ng1202-569 · Cited by 869
Helminth parasites – masters of regulation
Maizels, R. M., Balic, A., Gomez‐Escobar, N., Nair, M., Taylor, M. D., & Allen, J. E. (2004) · Immunological Reviews · doi:10.1111/j.0105-2896.2004.00191.x · Cited by 866
Disentangling Genetic Variation for Resistance and Tolerance to Infectious Diseases in Animals
Råberg, L., Sim, D., & Read, A. F. (2007) · Science · doi:10.1126/science.1148526 · Cited by 794
Self-citation
Cited by
Disease Tolerance as a Defense Strategy
Medzhitov, R., Schneider, D. S., & Soares, M. P. (2012) · Science · doi:10.1126/science.1214935 · Cited by 1,718
Rethinking IL-6 and CRP: Why they are more than inflammatory biomarkers, and why it matters
Del Giudice, M., & Gangestad, S. W. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2018.02.013 · Cited by 779
Ayres, J. S., & Schneider, D. S. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075030 · Cited by 475
Disease tolerance and immunity in host protection against infection
Soares, M. P., Teixeira, L., & Moita, L. F. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2016.136 · Cited by 376
Energetic Trade-Offs and Hypometabolic States Promote Disease Tolerance
Ganeshan, K., Nikkanen, J., Man, K., Leong, Y. A., Sogawa, Y., Maschek, J. A., Van Ry, T., Chagwedera, D. N., Cox, J. E., & Chawla, A. (2019) · Cell · doi:10.1016/j.cell.2019.01.050 · Cited by 286
Metadata
- Authors
- Råberg, L., Graham, A. L., & Read, A. F.
- Venue
- Philosophical Transactions of the Royal Society B: Biological Sciences
- Publisher
- The Royal Society
- Published
- 2008-10-16
- Volume
- 364
- Issue
- 1513
- Pages
- 37-49
- ISSN
- 0962-8436 (ISSN-L)
- 1471-2970
- OpenAlex
- W1980288207
- Cited by
- 850
- References
- 76
- FWCI
- 19.21
- Type
- journal article
- Language
- en
- Open access
- green
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- Råberg, L., Graham, A. L., & Read, A. F. (2009). Decomposing health: tolerance and resistance to parasites in animals. Philosophical Transactions of the Royal Society B: Biological Sciences. https://doi.org/10.1098/rstb.2008.0184
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