Streptomyces clavuligerus sp. nov., a -Lactam Antibiotic Producer
Abstract
A new species of Streptomyces which produces two new cephalosporin antibiotics is named and described. Sporophores are produced on an extensive aerial mycelium and consist of networks of short, sympodially branched hyphae. One to four spores are borne usually on short, club-shaped side branches. Sporophores eventually segment to form chains of spores. The spores are oblong to slightly cylindrical, smooth-walled, and gray to grayish green en masse. The species name proposed, Streptomyces clavuligerus, refers to the production of club-like side branches.
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Clavulanic acid was first purified as a β-lactamase inhibitor from S. clavuligerus ATCC 27064, isolated from South American soil in 1971.
“Clavulanic acid was first purified as a novel β-lactamase inhibitor from S. clavuligerus ATCC 27064, which was isolated from South American soil in 1971 (Higgens and Kastner, 1971; Brown et al., 1976).”
From Fermentation Conditions that Affect Clavulanic Acid Production in Streptomyces clavuligerus: A Systematic Review (2016) · cites this paper as Higgens and Kastner, 1971
The pH of the medium could affect the growth of S. clavuligerus, as it is described to grow between pH 5.0 and 8.5, but sporulation is not observed from pH 7.0 to 8.5.
“Similarly, pH of the medium could affect the growth of S. clavuligerus, as it is described to grow between pH 5.0 and 8.5, however sporulation is not observed from pH 7.0 to 8.5 (Higgens and Kastner, 1971).”
From Fermentation Conditions that Affect Clavulanic Acid Production in Streptomyces clavuligerus: A Systematic Review (2016) · cites this paper as Higgens and Kastner, 1971
Sporulation of Streptomyces clavuligerus is not observed from pH 7.0 to 8.5.
“however sporulation is not observed from pH 7.0 to 8.5 (Higgens and Kastner, 1971).”
From Fermentation Conditions that Affect Clavulanic Acid Production in Streptomyces clavuligerus: A Systematic Review (2016) · cites this paper as Higgens and Kastner, 1971
Clavulanic acid as a β-lactamase inhibitor was initially isolated from S. clavuligerus ATCC 27064 using the traditional fermentation system.
“Clavulanic acid as a β-lactamase inhibitor was initially isolated from S. clavuligerus ATCC 27064 using the traditional fermentation system (Higgens and Kastner, 1971; Brown et al., 1976).”
From Fermentation Conditions that Affect Clavulanic Acid Production in Streptomyces clavuligerus: A Systematic Review (2016) · cites this paper as Higgens and Kastner, 1971
S. clavuligerus ATCC 27064 was reported to have optimal growth from 26 to 30°C with no growth above 37°C.
“S. clavuligerus ATCC 27064 was reported to have optimal growth from 26 to 30°C with no growth above 37°C (Higgens and Kastner, 1971), while most of the selected studies reported that fermentation temperature ranged between 20 and 30°C.”
From Fermentation Conditions that Affect Clavulanic Acid Production in Streptomyces clavuligerus: A Systematic Review (2016) · cites this paper as Higgens and Kastner, 1971
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Ser, H.-L., Law, J. W.-F., Chaiyakunapruk, N., Jacob, S. A., Palanisamy, U. D., Chan, K.-G., Goh, B.-H., & Lee, L.-H. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00522 · Cited by 90 · see citing works
“Clavulanic acid was first purified as a novel β-lactamase inhibitor from S. clavuligerus ATCC 27064, which was isolated from South American soil in 1971 (Higgens and Kastner, 1971; Brown et al., 1976).”
BackgroundMethodResultInfluential
- Authors
- HIGGENS, C. E., & KASTNER, R. E.
- Affiliations
- Eli Lilly (United States) (US)
- Venue
- International Journal of Systematic Bacteriology
- Publisher
- Microbiology Society
- Published
- 1971-10-01
- Volume
- 21
- Issue
- 4
- Pages
- 326-331
- ISSN
- 0020-7713 (ISSN-L)
- 1465-2102
- OpenAlex
- W2069640968
- Cited by
- 112
- References
- 0
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 4 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 5
- FWCI
- 2.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Systematic Bacteriology (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Health Sciences › Medicine › Microbiology › Actinomycetales infections and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Enzyme Production and Characterization
- Keywords
- Streptomyces clavuligerus, new species, Streptomyces, beta-lactam antibiotics, cephalosporins, bacterial taxonomy, sporophore morphology, aerial mycelium, spore morphology
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